Zobrazeno 1 - 10
of 458
pro vyhledávání: '"N6‐methyladenine"'
Publikováno v:
Acta Biochimica et Biophysica Sinica, Vol 56, Pp 1723-1732 (2024)
Biological development and genetic information transfer are governed by genetic, epigenetic, transcriptional, and posttranscriptional mechanisms. RNA methylation, the attachment of methyl (–CH3) groups to RNA molecules, is a posttranscriptional mod
Externí odkaz:
https://doaj.org/article/286aac56c69b43cdad809550d2992fb5
Publikováno v:
Advanced Science, Vol 11, Iss 35, Pp n/a-n/a (2024)
Abstract Post‐replicative DNA N6‐methyladenine (pr6mdA) can form via bona fide methylase‐catalyzed adenine methylation, playing a pivotal role in embryonic development and other biological processes. Surprisingly, pre‐methylated adenine can b
Externí odkaz:
https://doaj.org/article/59b532f368f943f083d3cb61bacd341f
Publikováno v:
Poultry Science, Vol 103, Iss 9, Pp 103953- (2024)
ABSTRACT: Increased consumption of folic acid is prevalent due to its beneficial effects, but growing evidence emphasizes the side effects pointing to excessive dietary folate intake. The effects of excessive paternal folic acid consumption on offspr
Externí odkaz:
https://doaj.org/article/2b10b13ebafa4ae6a9d6f782cb7a7ed4
Autor:
Fangyi Yao, Fangmin Zhong, Junyao Jiang, Ying Cheng, Shuai Xu, Jing Liu, Jin Lin, Jing Zhang, Shuqi Li, Meiyong Li, Yanmei Xu, Bo Huang, Xiaozhong Wang
Publikováno v:
Genes and Diseases, Vol 11, Iss 2, Pp 993-1008 (2024)
Chronic myeloid leukemia (CML) is a common adult leukemia. Both the acute phase of the disease and the adverse effects of anti-cancer treatments can lead to a poor prognosis. The N6-methyladenine (m6A) modification plays an important regulatory role
Externí odkaz:
https://doaj.org/article/18be7aab6c184f62b6059464a67e75b0
Publikováno v:
Mathematical Biosciences and Engineering, Vol 21, Iss 3, Pp 3798-3815 (2024)
The DNA N6-methyladenine (6mA) is an epigenetic modification, which plays a pivotal role in biological processes encompassing gene expression, DNA replication, repair, and recombination. Therefore, the precise identification of 6mA sites is fundament
Externí odkaz:
https://doaj.org/article/368531e17aa243b79dba87cacf890712
Publikováno v:
Heliyon, Vol 10, Iss 13, Pp e33489- (2024)
AlkB homolog 1 (ALKBH1) is a member of the AlkB family of dioxygenases that are dependent on Fe(II) and α-ketoglutarate. Mounting evidence demonstrates that ALKBH1 exhibits enzymatic activity against various substrates, including N6-methyladenosine
Externí odkaz:
https://doaj.org/article/5e48b2461ac049fcb6b69abce1ccb190
Autor:
Ai Zhuang, Xiang Gu, Tongxin Ge, Shaoyun Wang, Shengfang Ge, Peiwei Chai, Renbing Jia, Xianqun Fan
Publikováno v:
Cancer Communications, Vol 43, Iss 11, Pp 1185-1206 (2023)
Abstract Background Diversified histone deacetylation inhibitors (HDACis) have demonstrated encouraging outcomes in multiple malignancies. N6‐methyladenine (m6A) is the most prevalent messenger RNA modification that plays an essential role in the r
Externí odkaz:
https://doaj.org/article/4ac9993639d944488fddab79b4e4859c
Publikováno v:
Neurology International, Vol 15, Iss 3, Pp 967-979 (2023)
Changes in epitranscriptome with N6-methyladenine (m6A) modification could be involved in the development of multiple diseases, which might be a prevalent modification of messenger RNAs (mRNAs) in eukaryotes. The m6A modification might be performed t
Externí odkaz:
https://doaj.org/article/7f3656aa665d4028b2a4908ed1929f1d
Autor:
Manon Boulet, Guerric Gilbert, Yoan Renaud, Martina Schmidt-Dengler, Emilie Plantié, Romane Bertrand, Xinsheng Nan, Tomasz Jurkowski, Mark Helm, Laurence Vandel, Lucas Waltzer
Publikováno v:
eLife, Vol 12 (2023)
N6-methyladenine (6mA) DNA modification has recently been described in metazoans, including in Drosophila, for which the erasure of this epigenetic mark has been ascribed to the ten-eleven translocation (TET) enzyme. Here, we re-evaluated 6mA presenc
Externí odkaz:
https://doaj.org/article/eebc17b941504cb9bf6392b11a80f6f0
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 644-654 (2023)
N6-methyladenine (6mA) plays a critical role in various epigenetic processing including DNA replication, DNA repair, silencing, transcription, and diseases such as cancer. To understand such epigenetic mechanisms, 6 mA has been detected by high-throu
Externí odkaz:
https://doaj.org/article/94fcfaaa13d947829dfbe09193bf283a