N439K Variant in Spike Protein Alter the Infection Efficiency and Antigenicity of SARS-CoV-2 Based on Molecular Dynamics Simulation

Autor: Wenyang Zhou, Chang Xu, Pingping Wang, Meng Luo, Zhaochun Xu, Rui Cheng, Xiyun Jin, Yu Guo, Guangfu Xue, Liran Juan, Anastasia A. Anashkina, Huan Nie, Qinghua Jiang

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing an outbreak of coronavirus disease 2019 (COVID-19), has been undergoing various mutations. The analysis of the structural and energetic effects of mutations on protein-protein inte

Externí odkaz: https://doaj.org/article/37ba098766774e3f8f952d10746acd84

Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity

Autor: Thomson, Emma C, Rosen, Laura E, Shepherd, James G, Spreafico, Roberto, da Silva Filipe, Ana, Wojcechowskyj, Jason A, Davis, Chris, Piccoli, Luca, Pascall, David J, Dillen, Josh, Lytras, Spyros, Czudnochowski, Nadine, Shah, Rajiv, Meury, Marcel, Jesudason, Natasha, De Marco, Anna, Li, Kathy, Bassi, Jessica, O'Toole, Aine, Pinto, Dora, Colquhoun, Rachel M, Culap, Katja, Jackson, Ben, Zatta, Fabrizia, Rambaut, Andrew, Jaconi, Stefano, Sreenu, Vattipally B, Nix, Jay, Zhang, Ivy, Jarrett, Ruth F, Glass, William G, Beltramello, Martina, Nomikou, Kyriaki, Pizzuto, Matteo, Tong, Lily, Cameroni, Elisabetta, Croll, Tristan I, Johnson, Natasha, Di Iulio, Julia, Wickenhagen, Arthur, Ceschi, Alessandro, Harbison, Aoife M, Mair, Daniel, Ferrari, Paolo, Smollett, Katherine, Sallusto, Federica, Carmichael, Stephen, Garzoni, Christian, Nichols, Jenna, Galli, Massimo, Hughes, Joseph, Riva, Agostino, Ho, Antonia, Schiuma, Marco, Semple, Malcolm G, Openshaw, Peter JM, Fadda, Elisa, Baillie, J Kenneth, Chodera, John D, Rihn, Suzannah J, Lycett, Samantha J, Virgin, Herbert W, Telenti, Amalio, Corti, Davide, Robertson, David L, Snell, Gyorgy, ISARIC4C Investigators, COVID-19 Genomics UK (COG-UK) Consortium

Publikováno v: Cell, vol 184, iss 5

SARS-CoV-2 can mutate and evade immunity, with consequences for efficacy of emerging vaccines and antibody therapeutics. Here, we demonstrate that the immunodominant SARS-CoV-2 spike (S) receptor binding motif (RBM) is a highly variable region of S a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd29de2d3e850b5539d4f7c26026952
https://escholarship.org/uc/item/09z3r8fn

The emerging SARS-CoV-2 variants of concern

Autor: Chuku Okorie, Nafees Haider, Aleksandra Marinkovic, Abu Fahad Abbasi, Urooj Jaferi, Adekunle Sanyaolu, Vyshnavy Balendra, Stephanie Prakash

Publikováno v: Therapeutic Advances in Infectious Disease
Therapeutic Advances in Infectious Disease, Vol 8 (2021)

Since emerging from Wuhan, China, in December of 2019, the coronavirus (SARS-CoV-2) has been causing devastating severe respiratory infections in humans worldwide. With the disease spreading faster than the medical community could contain it, death t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40adda70207ed73896ac3fae6ff6a18
https://doi.org/10.1177/20499361211024372

Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity.

Autor: Thomson EC; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK; Department of Clinical Research, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK., Rosen LE; Vir Biotechnology, San Francisco, CA 94158, USA., Shepherd JG; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Spreafico R; Vir Biotechnology, San Francisco, CA 94158, USA., da Silva Filipe A; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Wojcechowskyj JA; Vir Biotechnology, San Francisco, CA 94158, USA., Davis C; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Piccoli L; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Pascall DJ; Institute of Biodiversity, Animal Health and Comparative Medicine, Boyd Orr Centre for Population and Ecosystem Health, University of Glasgow, Glasgow G61 1QH, UK., Dillen J; Vir Biotechnology, San Francisco, CA 94158, USA., Lytras S; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Czudnochowski N; Vir Biotechnology, San Francisco, CA 94158, USA., Shah R; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Meury M; Vir Biotechnology, San Francisco, CA 94158, USA., Jesudason N; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., De Marco A; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Li K; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Bassi J; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., O'Toole A; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK., Pinto D; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Colquhoun RM; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK., Culap K; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Jackson B; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK., Zatta F; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Rambaut A; Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK., Jaconi S; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Sreenu VB; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Nix J; Molecular Biology Consortium, Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA., Zhang I; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Tri-Institutional PhD Program in Computational Biology and Medicine, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA., Jarrett RF; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Glass WG; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Beltramello M; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Nomikou K; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Pizzuto M; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Tong L; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Cameroni E; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Croll TI; Cambridge Institute for Medical Research, Department of Haematology, University of Cambridge, Cambridge CB2 0XY, UK., Johnson N; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Di Iulio J; Vir Biotechnology, San Francisco, CA 94158, USA., Wickenhagen A; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Ceschi A; Faculty of Biomedical Sciences, Università della Svizzera italiana, 6900 Lugano, Switzerland; Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences of Southern Switzerland, Ente Ospedaliero Cantonale, 6900 Lugano, Switzerland; Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, 8091 Zurich, Switzerland., Harbison AM; Department of Chemistry and Hamilton Institute, Maynooth University, Maynooth, Ireland., Mair D; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Ferrari P; Department of Nephrology, Ospedale Civico Lugano, Ente Ospedaliero Cantonale, 6900 Lugano, Switzerland; Prince of Wales Hospital Clinical School, University of New South Wales, Sydney, NSW 2052, Australia., Smollett K; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Sallusto F; Institute for Research in Biomedicine, Università della Svizzera italiana, 6500 Bellinzona, Switzerland; ETH Institute of Microbiology, ETH Zurich, 8093 Zürich, Switzerland., Carmichael S; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Garzoni C; Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, 6900 Lugano, Switzerland., Nichols J; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Galli M; III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, 20157 Milan, Italy., Hughes J; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Riva A; III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, 20157 Milan, Italy., Ho A; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Schiuma M; III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, 20157 Milan, Italy., Semple MG; NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, Faculty of Health and Life Sciences, University of Liverpool, Liverpool L69 7BE, UK; Respiratory Medicine, Alder Hey Children's Hospital, Liverpool L12 2AP, UK., Openshaw PJM; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK., Fadda E; Department of Chemistry and Hamilton Institute, Maynooth University, Maynooth, Ireland., Baillie JK; The Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, UK; Intensive Care Unit, Royal Infirmary Edinburgh, Edinburgh EH16 4SA, UK., Chodera JD; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Rihn SJ; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK., Lycett SJ; The Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, UK., Virgin HW; Vir Biotechnology, San Francisco, CA 94158, USA; Washington University School of Medicine, Saint Louis, MO 63110, USA., Telenti A; Vir Biotechnology, San Francisco, CA 94158, USA., Corti D; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Robertson DL; MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow G61 1QH, UK. Electronic address: david.l.robertson@glasgow.ac.uk., Snell G; Vir Biotechnology, San Francisco, CA 94158, USA. Electronic address: gsnell@vir.bio.

Publikováno v: Cell [Cell] 2021 Mar 04; Vol. 184 (5), pp. 1171-1187.e20. Date of Electronic Publication: 2021 Jan 28.