Transcriptional Profiling and Functional Analysis of N1/N2 Neutrophils Reveal an Immunomodulatory Effect of S100A9-Blockade on the Pro-Inflammatory N1 Subpopulation

Autor: Andreea C. Mihaila, Letitia Ciortan, Razvan D. Macarie, Mihaela Vadana, Sergiu Cecoltan, Mihai Bogdan Preda, Ariana Hudita, Ana-Maria Gan, Gabriel Jakobsson, Monica M. Tucureanu, Elena Barbu, Serban Balanescu, Maya Simionescu, Alexandru Schiopu, Elena Butoi

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Neutrophils have been classically viewed as a homogenous population. Recently, neutrophils were phenotypically classified into pro-inflammatory N1 and anti-inflammatory N2 sub-populations, but the functional differences between the two subtypes are n

Externí odkaz: https://doaj.org/article/c7e22488342b47439dfb2d1d1d46675e

Interleukin 10 modulation of neutrophil subsets infiltrating lungs during

Autor: Hernán F, Peñaloza, Francisco J, Salazar-Echegarai, Susan M, Bueno

Publikováno v: Biochemistry and Biophysics Reports

Interleukin-10 production and lung neutrophil infiltration are two essential components of the balanced immune response to pneumonia caused by Streptococcus pneumoniae. Here we describe the existence of two neutrophil subsets in lungs during experime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c29ff5f40aa9a6f299eda124f1aa0a58
https://pubmed.ncbi.nlm.nih.gov/29226257

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Interleukin 10 modulation of neutrophil subsets infiltrating lungs during Streptococcus pneumoniae infection.

Autor: Peñaloza HF; Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8331010, Chile., Salazar-Echegarai FJ; Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8331010, Chile., Bueno SM; Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago 8331010, Chile.

Publikováno v: Biochemistry and biophysics reports [Biochem Biophys Rep] 2017 Nov 22; Vol. 13, pp. 12-16. Date of Electronic Publication: 2017 Nov 22 (Print Publication: 2018).