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pro vyhledávání: '"N.W. Thomas"'
Akademický článek
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Publikováno v:
International Journal of Pharmaceutics. 117:139-146
An erythrocyte model has been used to investigate the membrane activity of various agents which have been employed as enhancers of intranasal drug absorption. Enhancers were ranked according to haemolytic activity as follows: LPC-stearoyl > laureth-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfaab2338b915db4b95ddc88276c8b9e
https://doi.org/10.1016/0378-5173(94)00308-r
https://doi.org/10.1016/0378-5173(94)00308-r
Publikováno v:
Journal of Controlled Release. 29:339-350
A range of fluorescent polystyrene microparticles (0.15, 0.5, 1.0, 3.0 and 10.0 μm) were administered intraduodenally to Wistar rats to provide an assessment of the levels of absorption of microparticles. Coupling a surgical procedure for the cannul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbe048f2e031f1f4a78b7615f34e24bc
https://doi.org/10.1016/0168-3659(94)90079-5
https://doi.org/10.1016/0168-3659(94)90079-5
Publikováno v:
International Journal of Pharmaceutics. 102:261-266
The absorption of polystyrene microparticles across the intestine of rats was examined as a preliminary assessment of the efficacy of particles as vaccine delivery systems. The superior mesenteric lymph ducts of groups (n = 5) of Wistar rats were can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d10685e7497e3357fc30cd84cf142c37
https://doi.org/10.1016/0378-5173(94)90064-7
https://doi.org/10.1016/0378-5173(94)90064-7
Publikováno v:
Pharmaceutical Research. 11:1623-1630
The intranasal absorption enhancing and histological effects of a range of lysophospholipids has been investigated in the rat. Blood glucose levels fell rapidly following the administration of insulin (8 IU/kg) in combination with lysophosphatidylcho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af36ba6f82e778cbad71a7c5775fe08b
https://doi.org/10.1023/a:1018970006935
https://doi.org/10.1023/a:1018970006935
Publikováno v:
Pharmaceutical Research. :878-883
The absorption of insulin across the vaginal mucosa into the systemic circulation was studied in ovariectomized rats given subsequent estrogen treatment. Blood glucose levels were determined as an indirect measure of insulin absorption, and the effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48675a6eff0340e5b0d6ff4023f8e994
https://doi.org/10.1023/a:1015892630637
https://doi.org/10.1023/a:1015892630637
Publikováno v:
International Journal of Pharmaceutics. 77:75-78
The recovery of the rat vaginal epithelium from the histological effects of absorption enhancers was assessed 24 h after treatment with laureth-9 and lysophosphatidylglycerol (LPG) solutions. In a control group of rats, the vaginal epithelium had a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9346b36019eff5d1210a8290a699efe3
https://doi.org/10.1016/0378-5173(91)90304-7
https://doi.org/10.1016/0378-5173(91)90304-7
Publikováno v:
International Journal of Pharmaceutics. 76:61-70
Intranasal formulations have been investigated using a combined absorption and histological model to determine the effects of different absorption enhancers on insulin uptake and nasal epithelium integrity. Based on changes in blood glucose levels, e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d5a77ee7b2e311deee8b59d503992b1
https://doi.org/10.1016/0378-5173(91)90344-n
https://doi.org/10.1016/0378-5173(91)90344-n
Publikováno v:
International Journal of Pharmaceutics. 70:19-27
A method is described which enables the controlled assessment of the effects of intranasal drug formulations on rat nasal epithelium. Damage to the nasal mucosa caused by the surfactant laureth-9 (1% w/v) was used as an indicator of the distribution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98135b1a27603c551d0ab838adbee74b
https://doi.org/10.1016/0378-5173(91)90159-l
https://doi.org/10.1016/0378-5173(91)90159-l
Akademický článek
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