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IL-4 alone and in combination with IL-10 protects against blood-induced cartilage damage

Autor: J.A. van Roon, F.P.J.G. Lafeber, N.W. Jansen, M.E. van Meegeren, M. J. G. Wenting, A.C.W. van Wesel, G. Roosendaal

Publikováno v: Osteoarthritis and Cartilage. 20:764-772

SummaryObjectiveIt has been reported that interleukin (IL)-10 limits blood-induced cartilage damage. Our aim was to study the effect of IL-4 alone and in combination with IL-10 on blood-induced cartilage damage.DesignHealthy human full thickness cart

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa7d90798f724e9cc5d4171a350b02f
https://doi.org/10.1016/j.joca.2012.04.002

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Understanding haemophilic arthropathy: an exploration of current open issues

Autor: Floris P J G Lafeber, Goris Roosendaal, N.W. Jansen

Publikováno v: British Journal of Haematology. 143:632-640

Haemophilic arthropathy is joint damage evolving from recurrent joint bleeds that occur in patients suffering from the clotting disorder haemophilia. Insight into the pathogenetic mechanism of this blood-induced arthropathy yields possible treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c77aab59005f355f75cca8d66a2db14c
https://doi.org/10.1111/j.1365-2141.2008.07386.x

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Blood-Induced Joint Damage: The Devastating Effects of Acute Joint Bleeds versus Micro-Bleeds

Autor: Floris P J G Lafeber, Monique E. R. van Meegeren, Goris Roosendaal, N.W. Jansen, Simon C. Mastbergen

Publikováno v: Cartilage

Objective: Four days of blood exposure leads to irreversible cartilage damage in vitro. In contrast, intermittent intra-articular blood injections twice a week during 4 weeks (mimicking micro-bleeds) in a canine model resulted in transient damage onl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63e62cf8d6f300f9128d7a44485ba11
https://pubmed.ncbi.nlm.nih.gov/26069675

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Biochemical markers of joint tissue damage increase shortly after a joint bleed; an explorative human and canine in vivo study

Autor: L. F. D. van Vulpen, G. Roosendaal, M.E. van Meegeren, Roger E. G. Schutgens, N.W. Jansen, J.M. van Laar, S.C. Mastbergen, F.P.J.G. Lafeber

Publikováno v: Osteoarthritis and Cartilage, 23, 1, pp. 63-9
Osteoarthritis and Cartilage, 23, 63-9
Osteoarthritis and Cartilage, 23(1), 63. W.B. Saunders Ltd

Item does not contain fulltext OBJECTIVE: Evaluation whether biomarkers of joint damage are sensitive to change shortly after a joint bleed in hemophilia patients and in a canine model of blood-induced joint damage. METHODS: Blood and urine samples w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2928ff12f0e47131577da78d295e820
https://doi.org/10.1016/j.joca.2014.09.008

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The non-ionic surfactant poloxamer P188 does not prevent blood-induced cartilage damage

Autor: Goris Roosendaal, N.W. Jansen, Matthias Theobald, J. W. J. Bijlsma, F.P.J.G. Lafeber

Publikováno v: Haemophilia. 14:868-870

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b78eda6d57ca3f9968a53d8c0368e5f
https://doi.org/10.1111/j.1365-2516.2008.01776.x

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The combination of the biomarkers urinary C-terminal telopeptide of type II collagen, serum cartilage oligomeric matrix protein, and serum chondroitin sulfate 846 reflects cartilage damage in hemophilic arthropathy

Autor: L. Heijnen, Floris P J G Lafeber, Björn Lundin, Matthias Theobald, Johannes W. J. Bijlsma, Evelien P. Mauser-Bunschoten, Goris Roosendaal, N.W. Jansen

Publikováno v: Arthritis and rheumatism. 60(1)

Objective. Hemophilic arthropathy, with characteristics of inflammatory (rheumatoid arthritis) and degenerative (osteoarthritis) joint damage, occurs at an early age, is associated with minor comorbidity, and is restricted to 3 pairs of large joints.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a72c5eecdc9249607abb1e947afda3
https://pubmed.ncbi.nlm.nih.gov/19116938

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Interleukin-10 protects against blood-induced joint damage

Autor: Michel J. J. Hooiveld, Goris Roosendaal, N.W. Jansen, Matthias Theobald, Joel A G van Roon, Floris P J G Lafeber, Johannes W. J. Bijlsma

Publikováno v: British journal of haematology. 142(6)

Summary Despite prophylactic treatment, haemophilia patients suffer from spontaneous joint bleeds, which lead to severe joint damage. Also after joint trauma, an intra-articular haemorrhage can add to joint damage over time. This study evaluated inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9963fff304d944444d2d9906d64272
https://pubmed.ncbi.nlm.nih.gov/18637801

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Digital scoring of haemophilic arthropathy using radiographs is feasible

Autor: L. Heijnen, Björn Lundin, Goris Roosendaal, N.W. Jansen, Koen L. Vincken, Holger Pettersson, A.C.A. Marijnissen, F.P.J.G. Lafeber

Publikováno v: Haemophilia : the official journal of the World Federation of Hemophilia. 14(5)

Radiographs are important tools to evaluate structural changes in many Joint diseases. In the case of haemophilic arthropathy (HA), the Pettersson score is widely used. The rising of digital radiography enables evaluation of these changes in a more q

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a934be09173813a9fca4d3ef264b1789
https://pubmed.ncbi.nlm.nih.gov/18625029

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