The 5-HT6 serotonin receptor antagonist SB-271046 attenuates the development and expression of nicotine-induced locomotor sensitisation in Wistar rats

Autor: Andrew C. McCreary, N.M.W.J. de Bruin, B.M. Kloeze

Publikováno v: Neuropharmacology. 61:451-457

5-HT 6 receptors are almost exclusively expressed in the central nervous system, particularly in areas relevant for addictive behaviour. Based on this, together with other data, this receptor may be a viable target for the control of drug abuse. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::74ed4da57075edea3ca585b8e1d9f2b9
https://doi.org/10.1016/j.neuropharm.2011.01.045

SLV330, a cannabinoid CB1 receptor antagonist, attenuates ethanol and nicotine seeking and improves inhibitory response control in rats

Autor: Kruse Cornelis G, T.J. De Vries, Anton N. M. Schoffelmeer, Josephus H. M. Lange, Arnoldus H.J. Herremans, N.M.W.J. de Bruin, M. van Drimmelen

Publikováno v: de Bruin, N M W J, Lange, J H M, Kruse, C G, Herremans, A H, Schoffelmeer, A N M, van Drimmelen, M & de Vries, T J 2011, ' SLV330, a cannabinoid CB(1) receptor antagonist, attenuates ethanol and nicotine seeking and improves inhibitory response control in rats ', Behavioural Brain Research, vol. 217, no. 2, pp. 408-415 . https://doi.org/10.1016/j.bbr.2010.11.013
Behavioural Brain Research, 217(2), 408-415. Elsevier

Cannabinoid CB 1 receptor (CB 1 R) signaling has been shown to play a role in the regulation of addictive behavior. In the present study, our aim was to investigate whether the CB 1 R antagonist SLV330 could reduce ethanol and nicotine self-administr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e67f975c3fd0653b0a29c8efea5e31
https://doi.org/10.1016/j.bbr.2010.11.013

Attentional performance of (C57BL/6J×129Sv)F2 mice in the five-choice serial reaction time task

Autor: F. Fransen, Anton Megens, C. Grantham, N.M.W.J. de Bruin, H. Duytschaever

Publikováno v: Physiology & Behavior. 89:692-703

Impaired attention is evident in several neurological and psychiatric disorders. In the present study, attentional capabilities were measured in the operant five-choice serial reaction time task (5-CSRTT) in male (C57BL/6J × 129Sv)F2 hybrid (B6129F2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91e83a5cca2f5c713581d8df599113c8
https://doi.org/10.1016/j.physbeh.2006.08.009

Combined uridine and choline administration improves cognitive deficits in spontaneously hypertensive rats

Autor: M.C De Wilde, Laus M. Broersen, N.M.W.J. de Bruin, Amanda J. Kiliaan

Publikováno v: Neurobiology of Learning and Memory, 80, 63-79
Neurobiology of Learning and Memory, 80, 1, pp. 63-79

Item does not contain fulltext Rationale. Hypertension is considered a risk factor for the development of cognitive disorders, because of its negative effects on cerebral vasculature and blood flow. Genetically induced hypertension in rats has been a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f7c6d657e3515710475769a890e1db
https://hdl.handle.net/2066/147151

A novel highly selective 5-HT6 receptor antagonist attenuates ethanol and nicotine seeking but does not affect inhibitory response control in Wistar rats

Autor: M. van Drimmelen, N.M.W.J. de Bruin, Andrew C. McCreary, C.G. Kruse, T.J. De Vries, Jennifer Venhorst, A. van Loevezijn

Publikováno v: Behavioural Brain Research, 236, 157-165. Elsevier
de Bruin, N M W J, McCreary, A C, van Loevezijn, A, de Vries, T J, Venhorst, J, van Drimmelen, M & Kruse, C G 2013, ' A novel highly selective 5-HT6 receptor antagonist attenuates ethanol and nicotine seeking but does not affect inhibitory response control in Wistar rats ', Behavioural Brain Research, vol. 236, pp. 157-165 . https://doi.org/10.1016/j.bbr.2012.08.048

Recent studies suggest a potential role for 5-hydroxytryptamine(6) (5-HT(6)) receptors in the regulation of addictive behavior. In the present study, our aim was to investigate whether the novel highly selective 5-HT(6) receptor antagonist compound (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e949703aa34260e60849b5d57fb6fa
https://research.vumc.nl/en/publications/1ff5ea48-f25e-47e3-a81c-1b05219d1a13