Výsledky vyhledávání - "N.M.A. van den Broek"

Pioglitazone treatment restores in vivo muscle oxidative capacity in a rat model of diabetes

Autor: Jolita Ciapaite, Klaas Nicolay, Jeanine J. Prompers, Bart Wessels, N.M.A. van den Broek, Sander M. Houten

Publikováno v: Diabetes, Obesity and Metabolism, 17(1), 52-60. Wiley-Blackwell
Diabetes, obesity & metabolism, 17(1), 52-60. Wiley-Blackwell
Diabetes obesity & metabolism, 17(1), 52-60. Wiley

Aim To determine the effect of pioglitazone treatment on in vivo and ex vivo muscle mitochondrial function in a rat model of diabetes. Methods Both the lean, healthy rats and the obese, diabetic rats are Zucker Diabetic Fatty (ZDF) rats. The homozygo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae173b9ceae7885f361bd61273964b7
https://doi.org/10.1111/dom.12388

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Physical Activity Is the Key Determinant of Skeletal Muscle Mitochondrial Function in Type 2 Diabetes

Autor: K Schoonderwoerd, Klaas Nicolay, Jeanine J. Prompers, N.M.A. van den Broek, L.J.C. van Loon, H.M.M.L. de Feyter, Hubert J.M. Smeets, F.H.J. van Tienen, Patrick J. Lindsey, Stephan F. E. Praet, I.F.M. de Coo

Publikováno v: Journal of Clinical Endocrinology & Metabolism, 97(9), 3261-3269. Oxford University Press
Journal of Clinical Endocrinology and Metabolism, 97(9), 3261-3269. Endocrine Society

Context: Conflicting data exist on mitochondrial function and physical activity in type 2 diabetes mellitus (T2DM) development. Objective: The aim was to assess mitochondrial function at different stages during T2DM development in combination with ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8dd83384aeeac94580bb8871ce65f2
https://pure.eur.nl/en/publications/ad67d8aa-4e41-4cd2-b0eb-b20147be6c5b

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Comparison of in vivo postexercise phosphocreatine recovery and resting ATP synthesis flux for the assessment of skeletal muscle mitochondrial function

Autor: N.M.A. van den Broek, Klaas Nicolay, Jeanine J. Prompers, Jolita Ciapaite

Publikováno v: American Journal of Physiology : Cell Physiology, 299(5), C1136-C1143. American Physiological Society

31P magnetic resonance spectroscopy (MRS) has been used to assess skeletal muscle mitochondrial function in vivo by measuring 1) phosphocreatine (PCr) recovery after exercise or 2) resting ATP synthesis flux with saturation transfer (ST). In this stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0000776ca8b8a80e78e2118d4f4606b
https://doi.org/10.1152/ajpcell.00200.2010

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Increased mitochondrial content rescuesin vivomuscle oxidative capacity in long‐term high‐fat‐diet‐fed rats

Autor: Jolita Ciapaite, N.M.A. van den Broek, Sander M. Houten, Ron J. A. Wanders, Jeroen A. L. Jeneson, Klaas Nicolay, Jeanine J. Prompers, H.M.M.L. de Feyter

Publikováno v: FASEB journal, 24(5), 1354-1364. FASEB
The FASEB Journal, 24(5), 1354-1364. FASEB

Mitochondria are thought to play a crucial role in the etiology of muscle insulin resistance (IR). The aim of this study was to gain more insight into the timing and nature of mitochondrial adaptations during the development of high-fat-diet (HFD)-in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9fbb20d7d6cc85a4be94eae5d43b943
https://doi.org/10.1096/fj.09-143842

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Early or advanced stage type 2 diabetes is not accompanied by in vivo skeletal muscle mitochondrial dysfunction

Autor: N.M.A. van den Broek, Stephan F. E. Praet, L.J.C. van Loon, H.M.M.L. de Feyter, Klaas Nicolay, Jeanine J. Prompers

Publikováno v: European Journal of Endocrinology, 158(5), 643-653. BioScientifica Ltd.
European Journal of Endocrinology, 158(5), 643-53. BioScientifica Ltd.

ObjectiveSeveral lines of evidence support a potential role of skeletal muscle mitochondrial dysfunction in the pathogenesis of insulin resistance and/or type 2 diabetes. However, it remains to be established whether mitochondrial dysfunction represe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6921e47571be59afed2140e03a6058de
https://cris.maastrichtuniversity.nl/en/publications/c9463ee7-00d3-478a-b847-06504f8868b1

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