WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis

Autor: Costantino Pitzalis, B.L. Thomas, S.E. Eldridge, Olga Addimanda, N.M. Eltawil, Jing Yu, Jochen Zwerina, J. Sherwood, G. Nalesso, Georg Schett, Francesco Dell'Accio, Leslie Dale, Anne Sophie Thorup

Publikováno v: Annals of the Rheumatic Diseases

ObjectiveBoth excessive and insufficient activation of WNT signalling results in cartilage breakdown and osteoarthritis. WNT16 is upregulated in the articular cartilage following injury and in osteoarthritis. Here, we investigate the function of WNT1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6050c14042c3a17866f8777075a888
http://hdl.handle.net/11585/590953

Drying of open animal joints in vivo subsequently causes cartilage degeneration

Autor: Anish K. Amin, Andrew C. Hall, Scott Paterson, A. H. R. W. Simpson, N.M. Eltawil

Publikováno v: Bone & Joint Research
Paterson, S I, Eltawil, N M, Simpson, A H R W, Amin, A K & Hall, A C 2016, ' Drying of open animal joints in vivo subsequently causes cartilage degeneration ', Bone and Joint Research, vol. 5, no. 4, pp. 137-144 . https://doi.org/10.1302/2046-3758.54.2000594
Paterson, S I, Eltawil, N M, Simpson, H, Amin, A K & Hall, A 2016, ' Drying of open animal joints in vivo subsequently causes cartilage degeneration. ', Journal of Bone and Joint Surgery, British Volume . https://doi.org/10.1302/2046-3758.54.2000594

Objectives During open orthopaedic surgery, joints may be exposed to air, potentially leading to cartilage drying and chondrocyte death, however, the long-term effects of joint drying in vivo are poorly understood. We used an animal model to investig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::391b4e812371bfe757ad35d2c843b797
https://pubmed.ncbi.nlm.nih.gov/27114348

Human single-chain variable fragment that specifically targets arthritic cartilage

Autor: Francesco Dell'Accio, Adam Al-Kashi, Christina Subang, N.M. Eltawil, Chris Hughes, Michael Seed, Cosimo De Bari, Bjarne Faurholm, Alessandra Marrelli, Antonio Manzo, Ahuva Nissim, Yuti Chernajovsky, David Gould, Paul G. Winyard

Publikováno v: Arthritis and Rheumatism

Objective To demonstrate that posttranslational modification of type II collagen (CII) by reactive oxygen species (ROS), which are known to be present in inflamed arthritic joints, can give rise to epitopes specific to damaged cartilage in rheumatoid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1dc1bacf9d0ec9b9284f245e89d05ef
https://pubmed.ncbi.nlm.nih.gov/20131274

A novel in vivo murine model of cartilage regeneration. Age and strain-dependent outcome after joint surface injury

Autor: Francesco Dell'Accio, C. De Bari, Costantino Pitzalis, P. Achan, N.M. Eltawil

Publikováno v: Osteoarthritis and Cartilage

Summary Objectives To generate and validate a murine model of joint surface repair following acute mechanical injury. Methods Full thickness defects were generated in the patellar groove of C57BL/6 and DBA/1 mice by microsurgery. Control knees were e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ae0badd28ea79ad40b91fc41feaa8c

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