Zobrazeno 1 - 10
of 107
pro vyhledávání: '"N.J. Goulding"'
Autor:
N.J. Goulding, Roderick Flower
Following 50 years of glucocorticoid use in a clinical setting, an international body of expert scientists and physicians presents the most expansive survey of glucocorticoid pharmacology to date. This work traces the history of glucocorticoid biolog
Akademický článek
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Autor:
N.J. Goulding, P.M. Guyre
Publikováno v:
Biochemical and Biophysical Research Communications. 192:351-358
The anti-inflammatory protein lipocortin 1 has been proposed as a mediator of some of the anti-inflammatory actions of glucocorticoid hormones. In view of reported glucocorticoid effects on leukocyte Fc gamma receptors, the effect of short-term lipoc
Autor:
N.J. Goulding, N.D. Hall
Publikováno v:
Pharmacology & Therapeutics. 58:249-261
This report reviews the evidence that cells within the immune system are subject to rhythmic influences that affect numbers of circulating cells and their function both in vitro and in vivo. It is concluded that, although periodicity has clearly been
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Autor:
N.J. Goulding, M.R. Podgorski, P.R. Sharland, B J O'Connor, J L Godolphin, Kian Fan Chung, R.J. Flower, Peter J. Barnes
Publikováno v:
Scopus-Elsevier
One of the postulated mechanisms of corticosteroid action is through the de novo synthesis and release of lipocortins. We assayed circulating antibodies to lipocortin-1 in sera obtained from normal (n = 67) and asthmatic (n = 57) subjects using an EL
Autor:
M.R. Podgorski, N.J. Goulding, John A. McGrath, Elizabeth Wong, R.J. Flower, Malcolm W. Greaves, Jason K. Rivers
Publikováno v:
British Journal of Dermatology. 123:569-572
Corticosteroids may mediate some of their anti-inflammatory effects via induction of a specific 38 kDa protein, lipocortin-I. Anti-lipocortin-I antibodies (ALA) were measured by enzyme-linked immunosorbent assay (ELISA) in 23 patients with plaque-typ
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Autor:
Paul M. Guyre, N.J Goulding
Publikováno v:
Immunology today. 13(8)
The mechanisms that regulate inflammatory responses, and their dysfunction in chronic inflammatory diseases, are poorly understood. Lipocortin 1 is a potential mediator of the anti-inflammatory effects of glucocorticoid hormones. Following the discov
Autor:
M Sampson, Peter J. Maddison, S H Peers, R.J. Flower, P.R. Sharland, J L Godolphin, N.J. Goulding
Publikováno v:
Lancet (London, England). 335(8703)
The presence and amount of the anti-inflammatory protein lipocortin 1 was determined in plasma and peripheral blood leucocytes by a highly specific, enzyme-linked immunosorbent assay. Within 120 min of a single intravenous dose of 100 mg hydrocortiso