Zobrazeno 1 - 10
of 44
pro vyhledávání: '"N.G. Irving"'
Autor:
J. Gheuens, J. J. Martin, Michael Mullan, Gerd Multhaup, N.G. Irving, Antoon Vandenberghe, Hugh Gurling, W. Van Hul, A. Genthe, John Hardy, A. Wehnert, A. Barton, M. Salbaum, Bernhard Horsthemke, Marc Bruyland, H Backhovens, S. J. Richards, Konrad Beyreuther, C. Van Broeckhoven, A. Holland, Robert Williamson, Colin L. Masters, Peter Raeymaekers, Patrick Cras
Publikováno v:
Nature
The gene coding for the amyloid protein, a component of neuritic plaques found in brain tissue from patients with Alzheimer's disease, has been localized to chromosome 21, and neighbouring polymorphic DNA markers segregate with Alzheimer's disease in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73777dee0f802153a1b26c3c1a5967a
https://doi.org/10.1038/329153a0
https://doi.org/10.1038/329153a0
Autor:
Roderick T. Bronson, Cheryl A. Kitt, Anny Wohn, Roger H. Reeves, Sangram S. Sisodia, N.G. Irving, Cecilia Schmidt, Muriel T. Davisson, Timothy H. Moran
Trisomy 21 or Down syndrome (DS) is the most frequent genetic cause of mental retardation, affecting one in 800 live born human beings. Mice with segmental trisomy 16 (Ts65Dn mice) are at dosage imbalance for genes corresponding to those on human chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8cb81f4c97de7b4a236b7455b5de4e
https://ora.ox.ac.uk/objects/uuid:25bd558e-7dd4-4e44-8810-6e3241c7ae32
https://ora.ox.ac.uk/objects/uuid:25bd558e-7dd4-4e44-8810-6e3241c7ae32
Autor:
Alan G. Clark, Lynda Allan, N.G. Irving, John A. Morrow, Marianthi Papakosta, Brian W. McFerran, J. L. Leith
The glycine transporter (GlyT-1b) is a Na(+)/Cl(-)-dependent electrogenic transporter which mediates the rapid re-uptake of glycine from the synaptic cleft. Based on its tissue distribution, GlyT-1 has been suggested to co-localise with the NMDA rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db96c57b37b2422b9ee9037e80e407c1
https://ora.ox.ac.uk/objects/uuid:4970424f-7988-45a5-b618-7e49b4ef3af0
https://ora.ox.ac.uk/objects/uuid:4970424f-7988-45a5-b618-7e49b4ef3af0
Utilizing a Mus spretus/Mus domesticus ( C57BL 10 ) interspecific backcross, we have constructed a multipoint genetic map of mouse chromosome 16 that extends 43.2 cM from the proximal Prm-1 locus to the distal Ets-2 locus. The genetic map incorporate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46aa275d96e4a49d4dcc81ddf060ef01
https://ora.ox.ac.uk/objects/uuid:07b3eff6-ae7c-485a-94ba-9fb001c380c3
https://ora.ox.ac.uk/objects/uuid:07b3eff6-ae7c-485a-94ba-9fb001c380c3
Autor:
Lindsay Gibson, David R. Barn, Mark Craighead, William Arbuckle, Rachel Milne, Hazel Sloan, Chris Claxton, Susan Elizabeth Napier, Matilda Bingham, Grant Wishart, Cliona P MacSweeney, Richard Goodwin, N.G. Irving, Zara Turnbull, Kirsteen Buchanan, Jeremy Presland, Angus R. Brown, Alan Byford, Chris Mort, Fiona Thomson, Susan Goutcher, James R. Baker, Lee Fielding, Trevor Young
The discovery of a novel series of 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamide antagonists of the vasopressin V(1A) receptor is disclosed. Compounds 47 and 48 were found to be high affinity, selective vasopressin V(1A) antagonists.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc0d41bbebfcb82e69bfeb8a58ca72c
https://doi.org/10.1016/j.bmcl.2011.02.096
https://doi.org/10.1016/j.bmcl.2011.02.096
Autor:
N.G. Irving, Jean Pierre Brion, Declan M. McLoughlin, Christopher C.J. Miller, Karelle Leroy, Janet Brownlees
Publikováno v:
European Journal of Neuroscience. 11:1988-1994
Aberrant metabolism of the amyloid precursor protein (APP) is believed to be at least part of the pathogenic process in Alzheimer's disease. The carboxy-terminus of APP has been shown to interact with the Mint/X11 family of phosphotyrosine binding (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95026934635710be562af69b6ae0099e
https://doi.org/10.1046/j.1460-9568.1999.00610.x
https://doi.org/10.1046/j.1460-9568.1999.00610.x
Publikováno v:
Biochemical Society Transactions. 26:497-500
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51a0de7f0bbd755ad5010b666044cff1
https://doi.org/10.1042/bst0260497
https://doi.org/10.1042/bst0260497
Publikováno v:
Journal of Neurology, Neurosurgery & Psychiatry. 64:711-715
Transgenic mouse technology has contributed much to our understanding of the function and dysfunction of the nervous system. It has helped us to model and test hypotheses relating to neurodegenerative diseases, such as Alzheimer’s disease and motor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6374b01cfe45c77b3000e6e12b1b76a5
https://doi.org/10.1136/jnnp.64.6.711
https://doi.org/10.1136/jnnp.64.6.711
Autor:
N.G. Irving, Christopher C.J. Miller
Publikováno v:
Neuroscience Letters. 222:71-74
We have studied the effect of overexpressing either wild-type or an Alzheimer's disease mutant Presenilin 1 (PS1) on tau phosphorylation in transfected Chinese hamster ovary (CHO) and COS cells. Tau transfected into these cells is predominantly non-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e226e81bad7b6d84edf4e14f3da370d8
https://doi.org/10.1016/s0304-3940(97)13343-2
https://doi.org/10.1016/s0304-3940(97)13343-2
Publikováno v:
Genomics. 21:144-149
One hundred progeny from each of two intersubspecific mouse backcrosses were used to construct a comparative genetic map of a region of mouse chromosome 10 (MMU10) that is homologous to the distal tip of the long arm of human chromosome 21 (HSA21). T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adfec6da34ce71c85a250392005f7301
https://doi.org/10.1006/geno.1994.1236
https://doi.org/10.1006/geno.1994.1236