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Pulsating Fluid Flow Increases Prostaglandin Production by Cultured Chicken Osteocytes—A Cytoskeleton-Dependent Process

Autor: Peter J. Nijweide, Jenneke Klein-Nulend, T. Vrijheid-Lammers, N.E. Ajubi, Elisabeth H. Burger, M. J. Alblas

Publikováno v: Biochemical and Biophysical Research Communications. 225:62-68

It has been postulated that the transduction of mechanical stress signals to bone cells occurs via loading-dependent flow of interstitial fluid through the lacuno-canalicular network of bone. We have shown earlier that chicken osteocytes release enha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ebc585d3e9cdeebc38ba6e6c96ce56
https://doi.org/10.1006/bbrc.1996.1131

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Pulsating Fluid Flow Increases Nitric Oxide (NO) Synthesis by Osteocytes but Not Periosteal Fibroblasts - Correlation with Prostaglandin Upregulation

Autor: P.J. Nijweide, E.H. Burger, Jenneke Klein-Nulend, N.E. Ajubi, C.M. Semeins

Publikováno v: Biochemical and Biophysical Research Communications, 217, 640-648. Academic Press Inc.
Klein Nulend, J, Semeins, C M, Ajubi, N E, Nijweide, P J & Burger, E H 1995, ' Pulsating fluid flow increases nitric oxide (NO) synthesis by osteocytes but not periosteal fibroblasts-correlation with prostaglandin upregulation. ', Biochemical and Biophysical Research Communications, vol. 217, pp. 640-648 . https://doi.org/10.1006/bbrc.1995.2822

Osteocytes are extremely sensitive to fluid shear stress, a phenomenon that may be related to mechanical adaptation of bone (FASEB J 9:441,1995). Here we examined the effect of pulsating fluid flow (PFF, 0.5 +/- 0.02 Pa, 5 Hz, 0.4 Pa/sec) on the rele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4732f8852976fc37c1d631fce398782
https://doi.org/10.1006/bbrc.1995.2822

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Differential stimulation of prostaglandin G/H synthase-2 in osteocytes and other osteogenic cells by pulsating fluid flow

Autor: N.E. Ajubi, Jenneke Klein-Nulend, Irene Westbroek, C.M. Semeins, M.J. Alblas, P.J. Nijweide, Elisabeth H. Burger

Publikováno v: Biochemical and Biophysical Research Communications, 268, 414-419. Academic Press Inc.
Westbroek, I, Ajubi, N E, Alblas, M J, Semeins, C M, Klein Nulend, J, Burger, E H & Nijweide, P J 2000, ' Differential stimulation of prostaglandin G/H synthase-2 in osteocytes and other osteogenic cells by pulsating fluid flow ', Biochemical and Biophysical Research Communications, vol. 268, pp. 414-419 . https://doi.org/10.1006/bbrc.2000.2154

Mechanical stress produces flow of fluid in the osteocytic lacunar–canalicular network, which is likely the physiological signal for the adaptive response of bone. We compared the induction of prostaglandin G/H synthase-2 (PGHS-2) by pulsating flui

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f52b85ffbf9ebed5c894a10740238f6
https://dare.uva.nl/personal/pure/en/publications/differential-stimulation-of-prostaglandin-gh-synthase2-in-osteocytes-and-other-osteogenic-cells-by-pulsating-fluid-flow(d35f6072-f9c5-4357-8f73-c5835a301fc5).html

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Biology of Osteocytes

Autor: P.J. Nijweide, E.M. Aarden, A. Van der Plas, N.E. Ajubi

Publisher Summary This chapter discusses the biology of osteocytes. Osteocytes are the most abundant cells of mature bone. At active sites of bone formation some of the osteoblasts lining the bone surface are incorporated in the bone matrix and diffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f2bfc21fce5f9ecd28f07613c678b81
https://doi.org/10.1016/s1569-2590(08)60134-2

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Sensitivity of osteocytes to biomechanical stress in vitro

Autor: Jenneke Klein-Nulend, P.J. Nijweide, Elisabeth H. Burger, John A. Frangos, C.M. Semeins, A van der Plas, N.E. Ajubi

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 9(5)

It has been known for more than a century that bone tissue adapts to functional stress by changes in structure and mass. However, the mechanism by which stress is translated into cellular activities of bone formation and resorption is unknown. We stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc6b18ebf20da18609386b8e8c81593
https://pubmed.ncbi.nlm.nih.gov/7896017

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