Zobrazeno 1 - 10
of 69
pro vyhledávání: '"N.-Y. Jiang"'
Publikováno v:
European Journal of Pharmacology. 336:51-63
Adrenomedullin, amylin and calcitonin gene-related peptides (CGRP) share close sequence homology and have overlapping spectra of biological activities, particularly with respect to cardiovascular and gastrointestinal functions. Comparisons of the eff
Autor:
John G. Lainchbury, A. M. Richards, N.-Y. Jiang, M G Nicholls, Garth J. S. Cooper, Timothy G. Yandle, Lynley K. Lewis, David H. Coy
Publikováno v:
Clinical Science. 92:467-472
1. Adrenomedullin, a recently discovered 52-amino-acid peptide hormone, circulates in plasma at low picomolar levels in man. Animal studies and studies in vitro indicate that it has diverse biological actions, including vasodilatation, natriuresis an
Autor:
N. Y. Jiang, Jacques-Pierre Moreau, Jia-Ming Qian, Sun Hyuk Kim, H. Frucht, David H. Coy, R. T. Jensen, Lu-Wa Wang, Jaw-Town Lin
Publikováno v:
Journal of Biological Chemistry. 266:16441-16447
During a search for possible cyclization points in shortened, potent bombesin agonists and antagonists, it was found that the joining of amino acid residues in positions 6 and 14 by various means resulted in retention of significant binding affinity
Autor:
Harold Frucht, D. H. Coy, Robert T. Jensen, N-Y. Jiang, Suming Huang, J P Moreau, J E Taylor, B. M. Haffar, L H Wang
Publikováno v:
Journal of Biological Chemistry. 265:15695-15703
In the present study we examined the effect of carboxyl-terminal modifications of des-Met14-bombesin (Bn) on Bn receptor affinity in murine 3T3 cells, rat and guinea pig pancreatic acini, and the ability to initiate biologic responses by synthesizing
Akademický článek
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Akademický článek
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Publikováno v:
Journal of nuclear medicine technology. 27(1)
The biological properties of a new neutral myocardial imaging agent 99mTcN(NOEt)2 were evaluated.Blood clearance in rabbits, biodistribution in rats, and initial myocardial imaging in dogs were performed.Radiochemical purity of 99mTcN(NOEt)2 was more
Autor:
N Y Jiang, Karen E. Callon, Garth J. S. Cooper, David H. Coy, Ian R. Reid, Jillian Cornish, Liqun Xiao
Publikováno v:
The American journal of physiology. 273(6)
Adrenomedullin is a 52-amino acid vasodilator peptide produced in many tissues, including bone. It has 20% sequence identity with amylin, a regulator of osteoblast growth, and circulates in picomolar concentrations. The present study assesses whether
Publikováno v:
Annals of the New York Academy of Sciences. 805
Autor:
Samuel A. Mantey, David H. Coy, Robert T. Jensen, N. Y. Jiang, Fishbein Va, John E. Mrozinski, Simon J. Hocart
Publikováno v:
Peptides. 15(1)
The ability to assess the importance of VIP in different physiological processes is limited by the lack of specific potent antagonists. In the present study, we have adopted two different approaches used successfully with other peptides in an attempt