Resolving the fibrotic niche of human liver cirrhosis at single cell level

Autor: Mirjana Efremova, Ross Dobie, Jonathan A. Fallowfield, Prakash Ramachandran, Stephen J. Wigmore, John P. Iredale, Ewen M Harrison, Kylie P. Matchett, John C. Marioni, David R. Mole, Christopher J. Weston, John A. Marwick, John R. Wilson-Kanamori, Roser Vento-Tormo, Philip N. Newsome, Sarah A. Teichmann, Neil C. Henderson, Neil O. Carragher, Richard S Taylor, Jordan R. Portman, Elena Dora, N T Luu, Frank Tacke, Chris P. Ponting, Jeffrey W. Pollard, Beth E. P. Henderson, Timothy J. Kendall, M Brice

Publikováno v: Nature
Ramachandran, P, Dobie, R, Wilson-Kanamori, J R, Dora, E F, Henderson, B E P, Luu, N T, Portman, J R, Matchett, K P, Brice, M, Marwick, J A, Taylor, R S, Efremova, M, Vento-Tormo, R, Carragher, N O, Kendall, T J, Fallowfield, J A, Harrison, E M, Mole, D J, Wigmore, S J, Newsome, P N, Weston, C J, Iredale, J P, Tacke, F, Pollard, J W, Ponting, C P, Marioni, J C, Teichmann, S A & Henderson, N C 2019, ' Resolving the fibrotic niche of human liver cirrhosis at single-cell level ', Nature, vol. 575, no. 7783, pp. 512–518 . https://doi.org/10.1038/s41586-019-1631-3

Liver cirrhosis is a major cause of death worldwide and is characterized by extensive fibrosis. There are currently no effective antifibrotic therapies available. To obtain a better understanding of the cellular and molecular mechanisms involved in d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3362c457a2a6d54f3fadf6498190b2
http://europepmc.org/articles/PMC6876711

Cell therapy for acute liver injury- in vivo efficacy of mesenchymal stromal cells in toxic and immune-mediated murine hepatitis

Autor: M. Alfaifi, V. Vigneswara, N.-T. Luu, C. Baan, M. Hoogduijn, M. Gargesha, D. Roy, S. Elliman, L. O’flynn, G.M. Hirschfield, P.N. Newsome

Publikováno v: Journal of Hepatology. 68:S454-S455

The ability of umbilical cord-derived mesenchymal stromal cells (UC-MSCs) to immunomodulate offers therapeutic potential in liver injury but the inherent heterogeneity of unsorted MSC populations may explain varied/reduced function as well as posing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66bf4668a4404af78e1950cd2ab82c39
https://doi.org/10.1016/s0168-8278(18)31153-x

Antineutrophil cytoplasmic antibodies stabilize adhesion and promote migration of flowing neutrophils on endothelial cells

Autor: D J, Radford, N T, Luu, P, Hewins, G B, Nash, C O, Savage

Publikováno v: Arthritis and rheumatism. 44(12)

Recruitment of neutrophils to sites of inflammation requires coordinated regulation of their capture, activation, and migration on vascular endothelium. This study examines whether exposure of neutrophils to antineutrophil cytoplasmic antibodies (ANC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dbea36f85b57ea04641725a39f155473
https://pubmed.ncbi.nlm.nih.gov/11762946

Attenuation of ozone-induced airway permeability in rats by pretreatment with cyclophosphamide, FPL 55712, and indomethacin

Autor: D. K. Bhalla, N. T. Luu, D. S. Daniels

Publikováno v: American journal of respiratory cell and molecular biology. 7(1)

Exposure of rats to ozone (O3) produces an increase in airway permeability and a concomitant influx of polymorphonuclear leukocytes in the lung. These observations raise the possibility that the inflammatory cells play a role in the cellular injury a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b55bf6cfbad569d6b76147a5016942ba
https://pubmed.ncbi.nlm.nih.gov/1320904

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