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Akademický článek

Engineered Extracellular Vesicles: Emerging Therapeutic Strategies for Translational Applications

Autor: Jessica N. Ziegler, Changhai Tian

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 20, p 15206 (2023)

Extracellular vesicles (EVs) are small, membrane-bound vesicles used by cells to deliver biological cargo such as proteins, mRNA, and other biomolecules from one cell to another, thus inducing a specific response in the target cell and are a powerful

Externí odkaz: https://doaj.org/article/c37fb156eff4475f82f3dcbe3cbe4ff5

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Akademický článek

Extracellular Vesicle MicroRNAs in Heart Failure: Pathophysiological Mediators and Therapeutic Targets

Autor: Changhai Tian, Jessica N. Ziegler, Irving H. Zucker

Publikováno v: Cells, Vol 12, Iss 17, p 2145 (2023)

Extracellular vesicles (EVs) are emerging mediators of intracellular and inter-organ communications in cardiovascular diseases (CVDs), especially in the pathogenesis of heart failure through the transference of EV-containing bioactive substances. mic

Externí odkaz: https://doaj.org/article/fed1307fb4c548fe905cd5ec92b5b784

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Akademický článek

Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine

Autor: Amber N. Ziegler, Qiang Feng, Shravanthi Chidambaram, Jaimie M. Testai, Ekta Kumari, Deborah E. Rothbard, Miguel Constancia, Ionel Sandovici, Tara Cominski, Kevin Pang, Nan Gao, Teresa L. Wood, Steven W. Levison

Publikováno v: Stem Cell Reports, Vol 12, Iss 4, Pp 816-830 (2019)

Summary: Tissue-specific stem cells have unique properties and growth requirements, but a small set of juxtacrine and paracrine signals have been identified that are required across multiple niches. Whereas insulin-like growth factor II (IGF-II) is n

Externí odkaz: https://doaj.org/article/37b18af9b7bb486e8adcbcdaf7f3aeae

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Genetic mapping and phenotypic analysis of

Autor: Elyse M, Talley, Charlie T, Watts, Sonia, Aboyer, Madeline G, Adamson, Harriet Ab, Akoto, Haley, Altemus, Philip J, Avella, Rebecca, Bailey, Elizabeth R, Bell, Katheryn L, Bell, Kelsey, Breneman, Jessica S, Burkhart, Logan J, Chanley, Savannah S, Cook, Mackenzie T, DesLaurier, Timothy R, Dorsey, Cassandra J, Doyle, Merris E, Egloff, Ayoola S, Fasawe, Katy K, Garcia, Nathaniel P, Graves, Tyler K, Gray, Evan M, Gustafson, Makayla J, Hall, Jaden D, Hayes, Lindsay J, Holic, Brice A, Jarvis, Piotr S, Klos, Sidney, Kritzmire, Lera, Kuzovko, Edwyna, Lainez, Shamerra, McCoy, James C, Mierendorf, Nicole A, Neri, Caley R, Neville, Kelley, Osborn, Kaitlyn, Parker, Megan E, Parks, Kylee, Peck, Robyn, Pitt, Matthew E, Platta, Brianna, Powell, Katalina, Rodriguez, Clara, Ruiz, Mariah N, Schaefer, Amanda B, Shields, Jasmine B, Smiley, Briona, Stauffer, Devan, Straub, John L, Sweeney, Kaitlyn M, Termine, Brett, Thomas, Sophia D, Toth, Taylor R, Veile, Kayla S, Walker, Paige N, Webster, Brian J, Woodard, Quentin L, Yoder, McKenzie K, Young, McKenzie L, Zeedyk, Logan N, Ziegler, Kayla L, Bieser, David P, Puthoff, Joyce, Stamm, Alysia D, Vrailas-Mortimer, Jacob D, Kagey, Julie A, Merkle

Publikováno v: microPublication Biology

Genetic screens are used to identify genes involved in specific biological processes. An EMS mutagenesis screen in Drosophila melanogaster identified growth control phenotypes in the developing eye. One mutant line from this screen, H.3.2, was phenot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::80dba67da7aa929296386c29a138c0c2
https://pubmed.ncbi.nlm.nih.gov/34278244

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Akademický článek

Insulin-Like Growth Factor Receptor Signaling is Necessary for Epidermal Growth Factor Mediated Proliferation of SVZ Neural Precursors Following Neonatal Hypoxia-Ischemia

Autor: Dhivyaa eAlagappan, Amber N. Ziegler, Shravanthi eChidambaram, Jungsoo eMin, Teresa L. Wood, Steven W. Levison

Publikováno v: Frontiers in Neurology, Vol 5 (2014)

In this study we assessed the importance of insulin-like growth factor (IGF) and epidermal growth factor (EGF) receptor co-signaling for rat neural precursor (NP) cell proliferation and self-renewal in the context of a developmental brain injury that

Externí odkaz: https://doaj.org/article/9b00c7088037412a9a7d074bf6eaa208

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