Zobrazeno 1 - 10
of 12
pro vyhledávání: '"N. Yi Mok"'
Autor:
A. Elisa Pasqua, Swee Y. Sharp, Nicola E. A. Chessum, Angela Hayes, Loredana Pellegrino, Michael J. Tucker, Asadh Miah, Birgit Wilding, Lindsay E. Evans, Carl S. Rye, N. Yi Mok, Manjuan Liu, Alan T. Henley, Sharon Gowan, Emmanuel De Billy, Robert te Poele, Marissa Powers, Suzanne A. Eccles, Paul A. Clarke, Florence I. Raynaud, Paul Workman, Keith Jones, Matthew D. Cheeseman
Publikováno v:
Journal of Medicinal Chemistry. 66:5907-5936
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::719374538241e3474602d329b097d75c
https://doi.org/10.1021/acs.jmedchem.3c00156
https://doi.org/10.1021/acs.jmedchem.3c00156
Autor:
Yann-Vaï Le Bihan, Manjuan Liu, Angela Hayes, Ching Thai, Julian Blagg, Rachel M. Lanigan, Florence I. Raynaud, Butrus Atrash, Vassilios Bavetsias, Jemmy Sejberg, N. Yi Mok, Alan T. Henley
Publikováno v:
Xenobiotica; the Fate of Foreign Compounds in Biological Systems
1. We have previously described C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-one derivatives as cell permeable inhibitors of the KDM4 and KDM5 subfamilies of JmjC histone lysine demethylases. 2. Although exemplar compound 1 exhibited moderate clearanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d89df884bfbd35d3b7623873cf775692
https://doi.org/10.1080/00498254.2016.1230245
https://doi.org/10.1080/00498254.2016.1230245
Publikováno v:
Journal of Chemical Information and Modeling
Analyzing the chemical space coverage in commercial fragment screening collections revealed the overlap between bioactive medicinal chemistry substructures and rule-of-three compliant fragments is only ∼25%. We recommend including these fragments i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e897236014fd147dc1713b6a817868b2
https://doi.org/10.1021/ci400632y
https://doi.org/10.1021/ci400632y
Autor:
Nathan J. Brown, N. Yi Mok
Publikováno v:
Journal of chemical information and modeling. 57(1)
Establishing structure-activity relationships (SARs) in hit identification during early stage drug discovery is important in accelerating hit confirmation and expansion. We describe the development of EnCore, a systematic molecular scaffold enumerati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae33f1df08b1032cd5b9b07b823db26a
https://pubmed.ncbi.nlm.nih.gov/27990817
https://pubmed.ncbi.nlm.nih.gov/27990817
Publikováno v:
Journal of Chemical Information and Modeling
The efficiency of automated compound screening is heavily influenced by the design and the quality of the screening libraries used. We recently reported on the assembly of one diverse and one target-focused lead-like screening library. Using data fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f158afec1cc09ca9916b6925d413b1f0
https://doi.org/10.1021/ci300382f
https://doi.org/10.1021/ci300382f
Autor:
N. Yi Mok, James Chadwick, Nigel M. Hooper, Colin W. G. Fishwick, Katherine A.B. Kellett, A. Peter Johnson, Eva Casas-Arce
Publikováno v:
Journal of Medicinal Chemistry. 56:1843-1852
β-Secretase (BACE1), the enzyme responsible for the first and rate-limiting step in the production of amyloid-β peptides, is an attractive target for the treatment of Alzheimer's disease. In this study, we report the application of the de novo frag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87eee5b0f246f6a91d3234516d2b3306
https://doi.org/10.1021/jm301127x
https://doi.org/10.1021/jm301127x
Publikováno v:
Future medicinal chemistry. 8(14)
Many medicinal chemistry-relevant structures and core scaffolds tend toward geometric planarity, which hampers the optimization of physicochemical properties desirable in drug-like molecules. As challenging drug target classes emerge, the exploitatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6031f42ea595d944caa8775b31daae93
https://pubmed.ncbi.nlm.nih.gov/27572621
https://pubmed.ncbi.nlm.nih.gov/27572621
Autor:
Ruth Brenk, N. Yi Mok
Publikováno v:
Journal of Chemical Information and Modeling
The ChEMBL database was mined to efficiently assemble an ion channel-focused screening library. The compiled library consists of 3241 compounds representing 123 templates across nine ion channel categories. Compounds in the screening library are anno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::729670b38c45f3d94b9c320f82f18fdd
https://doi.org/10.1021/ci200260t
https://doi.org/10.1021/ci200260t
Autor:
Alan H. Fairlamb, Victoria Smith, Daniel Spinks, Julie A. Frearson, Ruth Brenk, Suzanne Norval, Andrew Woodland, Paul G. Wyatt, Iain T. Collie, Ian H. Gilbert, Laura A. T. Cleghorn, Kevin D. Read, N. Yi Mok, Irene Hallyburton
Publikováno v:
Chemmedchem
Screening of the Sigma-Aldrich Library of Pharmacologically Active Compounds (LOPAC) against cultured Trypanosoma brucei, the causative agent of African sleeping sickness, resulted in the identification of a number of compounds with selective antipro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae13d4a2d2cb7098bf2bf745fcdba3d
https://doi.org/10.1002/cmdc.201100278
https://doi.org/10.1002/cmdc.201100278
Autor:
Colin W. G. Fishwick, James Chadwick, Nigel M. Hooper, A. Peter Johnson, N. Yi Mok, Katherine A.B. Kellett
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6770-6774
A novel series of isatin-based inhibitors of beta-secretase (BACE-1) have been identified using a virtual high-throughput screening approach. Structure-activity relationship studies revealed structural features important for inhibition. Docking studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e85276a9f8e0dbacdf58c816fc4735
https://doi.org/10.1016/j.bmcl.2009.09.103
https://doi.org/10.1016/j.bmcl.2009.09.103