Zobrazeno 1 - 10
of 88
pro vyhledávání: '"N. Wishart"'
Autor:
Jian Du, Alfonso de Dios, Richard B. Gaynor, James J. Starling, Xiang S. Ye, Amit Aggarwal, Song Wu, Shuyu Li, Yuewei Qian, Gregory P. Donoho, Aimee B. Lin, Bart W. Halstead, Sean E. Sissons, Douglas Zeckner, Robert T. Foreman, Timothy I. Meier, Phillip W. Iversen, Damien M. Cronier, Rose T. Ajamie, Graham N. Wishart, Raquel Torrres, Santiago Carballares, Kevin R. Fales, Emiko L. Kreklau, Maria J. Lallena, Tinggui Yin
PDF - 1128K, Figure S1. Knockdown of CDK7 and CDK9 can inhibit RNAP II CTD P-Ser2 and P-Ser5. Figure S2. LY2857785 and flavopiridol inhibit MCL-1, XIAP protein expression and induce CASP-3 and cleaved PARP in AML cell MV-4-11. Table S1. LY2857785 inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb62eb48bfbf19159c380c73cb9da0d
https://doi.org/10.1158/1535-7163.22500105.v1
https://doi.org/10.1158/1535-7163.22500105.v1
Autor:
Jian Du, Alfonso de Dios, Richard B. Gaynor, James J. Starling, Xiang S. Ye, Amit Aggarwal, Song Wu, Shuyu Li, Yuewei Qian, Gregory P. Donoho, Aimee B. Lin, Bart W. Halstead, Sean E. Sissons, Douglas Zeckner, Robert T. Foreman, Timothy I. Meier, Phillip W. Iversen, Damien M. Cronier, Rose T. Ajamie, Graham N. Wishart, Raquel Torrres, Santiago Carballares, Kevin R. Fales, Emiko L. Kreklau, Maria J. Lallena, Tinggui Yin
XLSX - 54K, Table S2. 261 probsets gene signature in sens and res cell lines in Excel format.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70fa29c964bb208bbfee904a5d0548e
https://doi.org/10.1158/1535-7163.22500102
https://doi.org/10.1158/1535-7163.22500102
Autor:
Jian Du, Alfonso de Dios, Richard B. Gaynor, James J. Starling, Xiang S. Ye, Amit Aggarwal, Song Wu, Shuyu Li, Yuewei Qian, Gregory P. Donoho, Aimee B. Lin, Bart W. Halstead, Sean E. Sissons, Douglas Zeckner, Robert T. Foreman, Timothy I. Meier, Phillip W. Iversen, Damien M. Cronier, Rose T. Ajamie, Graham N. Wishart, Raquel Torrres, Santiago Carballares, Kevin R. Fales, Emiko L. Kreklau, Maria J. Lallena, Tinggui Yin
DNA-dependent RNA polymerase II (RNAP II) largest subunit RPB1 C-terminal domain (CTD) kinases, including CDK9, are serine/threonine kinases known to regulate transcriptional initiation and elongation by phosphorylating Ser 2, 5, and 7 residues on CT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b805b19504f4ca7d3dd3ca23723e6c77
https://doi.org/10.1158/1535-7163.c.6536355
https://doi.org/10.1158/1535-7163.c.6536355
Autor:
Damien M. Cronier, Lawrence M. Gelbert, Graham N. Wishart, Alfonso De Dios, Edward M. Chan, Richard P. Beckmann, Teresa Burke, Rose T. Ajamie, Shufen Cai, Sonya C. Tate
PDF file - 247KB, Model simulations of the plasma concentration, the biomarker levels of p-Rb, TopoIIalpha and pHH3, and the effect parameters driving tumor growth inhibition for a 21 day daily dosing regimen of 25 (red line), 50 (blue line) and 100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::328b5db9af7e29850dcb2c11a77a6b18
https://doi.org/10.1158/1078-0432.22446507
https://doi.org/10.1158/1078-0432.22446507
Autor:
Damien M. Cronier, Lawrence M. Gelbert, Graham N. Wishart, Alfonso De Dios, Edward M. Chan, Richard P. Beckmann, Teresa Burke, Rose T. Ajamie, Shufen Cai, Sonya C. Tate
PDF file - 122KB, Supplementary Table 1. Summary of available PK and biomarker data. Supplementary Table 2. Definitions of PK, biomarker and tumor model parameters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76827ed468388af5771b3df533a9ebe7
https://doi.org/10.1158/1078-0432.22446498.v1
https://doi.org/10.1158/1078-0432.22446498.v1
Autor:
Damien M. Cronier, Lawrence M. Gelbert, Graham N. Wishart, Alfonso De Dios, Edward M. Chan, Richard P. Beckmann, Teresa Burke, Rose T. Ajamie, Shufen Cai, Sonya C. Tate
PDF file - 350KB, Model simulations of tumor size dynamics for 17 days of growth followed by a 21-day daily dosing regimen of 25, 50 and 100 mg/kg of LY2835219 for the full model (green line) or for the model incorporating tumor growth inhibition by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f542acecc405ae012ad2cbf8306d53b
https://doi.org/10.1158/1078-0432.22446501
https://doi.org/10.1158/1078-0432.22446501
Autor:
Damien M. Cronier, Lawrence M. Gelbert, Graham N. Wishart, Alfonso De Dios, Edward M. Chan, Richard P. Beckmann, Teresa Burke, Rose T. Ajamie, Shufen Cai, Sonya C. Tate
Purpose: Selective inhibition of cyclin-dependent kinases 4 and 6 (CDK4/6) represents a promising therapeutic strategy. However, despite documented evidence of clinical activity, limited information is available on the optimal dosing strategy of CDK4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286ba70f009fb65ac0846f1a6cec9338
https://doi.org/10.1158/1078-0432.c.6520773
https://doi.org/10.1158/1078-0432.c.6520773
Autor:
Damien M. Cronier, Lawrence M. Gelbert, Graham N. Wishart, Alfonso De Dios, Edward M. Chan, Richard P. Beckmann, Teresa Burke, Rose T. Ajamie, Shufen Cai, Sonya C. Tate
PDF file - 22KB, Model simulated dose response curve for the average (red line), minimum (green line) and maximum (blue line) levels of p-Rb and pHH3 over a 24 period at steady state following daily dosing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae8ea6e278aa31bbedc60661a353a3f
https://doi.org/10.1158/1078-0432.22446504
https://doi.org/10.1158/1078-0432.22446504
Autor:
Damien M. Cronier, Lawrence M. Gelbert, Graham N. Wishart, Alfonso De Dios, Edward M. Chan, Richard P. Beckmann, Teresa Burke, Rose T. Ajamie, Shufen Cai, Sonya C. Tate
PDF file - 76KB, External validation of the biomarker model by VPC with data collected in colo-205 following daily oral dosing of 50 mg/kg of LY2835219 for 56 days or two cycles of 50 mg/kg for 21 days with a 7 day rest period.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b3710b8e985ef48e97f9ff015bd343
https://doi.org/10.1158/1078-0432.22446510.v1
https://doi.org/10.1158/1078-0432.22446510.v1
Autor:
Damien M. Cronier, Lawrence M. Gelbert, Graham N. Wishart, Alfonso De Dios, Edward M. Chan, Richard P. Beckmann, Teresa Burke, Rose T. Ajamie, Shufen Cai, Sonya C. Tate
PDF file - 71KB, VPC of the biomarker model in colo-205 xenograft bearing mice following a single 3.125, 6.25 or 12.5 mg/kg oral dose of LY2835219.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce2ed0a7ee21e2c127182966c4454b9
https://doi.org/10.1158/1078-0432.22446513.v1
https://doi.org/10.1158/1078-0432.22446513.v1