Zobrazeno 1 - 10
of 1 675
pro vyhledávání: '"N. Wein"'
Autor:
Sara Moradi Tuchayi, Yeva Khachatryan, Ying Wang, R. Rox Anderson, Jialiang S. Wang, Marc N. Wein, Lilit Garibyan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Reduction in visceral adipose tissue (VAT) mass reduces body weight and metabolic disease risk in obese patients. However surgical removal of VAT is highly invasive and thus not clinically feasible. We developed an injectable ice slurry for
Externí odkaz:
https://doaj.org/article/b84a7cd2d8714ff4bbcf30f2d2f2379d
Autor:
Sung-Hee Yoon, Mark B. Meyer, Carlos Arevalo, Murat Tekguc, Chengcheng Zhang, Jialiang S. Wang, Christian D. Castro Andrade, Katelyn Strauss, Tadatoshi Sato, Nancy A. Benkusky, Seong Min Lee, Rebecca Berdeaux, Marc Foretz, Thomas B. Sundberg, Ramnik J. Xavier, Charles H. Adelmann, Daniel J. Brooks, Anthony Anselmo, Ruslan I. Sadreyev, Ivy A. Rosales, David E. Fisher, Navin Gupta, Ryuji Morizane, Anna Greka, J. Wesley Pike, Michael Mannstadt, Marc N. Wein
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
The renal actions of parathyroid hormone (PTH) promote 1,25-vitamin D generation; however, the signaling mechanisms that control PTH-dependent vitamin D activation remain unknown. Here, we demonstrated that salt-inducible kinases (SIKs) orchestrated
Externí odkaz:
https://doaj.org/article/807eb29db7bc4680b7215fddd31857a3
Autor:
Wen Zhou, Petra Simic, Iris Y. Zhou, Peter Caravan, Xavier Vela Parada, Donghai Wen, Onica L. Washington, Maria Shvedova, Kerry A. Pierce, Clary B. Clish, Michael Mannstadt, Tatsuya Kobayashi, Marc N. Wein, Harald Jüppner, Eugene P. Rhee
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
How phosphate levels are detected in mammals is unknown. The bone-derived hormone fibroblast growth factor 23 (FGF23) lowers blood phosphate levels by reducing kidney phosphate reabsorption and 1,25(OH)2D production, but phosphate does not directly s
Externí odkaz:
https://doaj.org/article/e89541dfb86a4e3cba30439d498ee8eb
Autor:
Jialiang S. Wang, Tushar Kamath, Courtney M. Mazur, Fatemeh Mirzamohammadi, Daniel Rotter, Hironori Hojo, Christian D. Castro, Nicha Tokavanich, Rushi Patel, Nicolas Govea, Tetsuya Enishi, Yunshu Wu, Janaina da Silva Martins, Michael Bruce, Daniel J. Brooks, Mary L. Bouxsein, Danielle Tokarz, Charles P. Lin, Abdul Abdul, Evan Z. Macosko, Melissa Fiscaletti, Craig F. Munns, Pearl Ryder, Maria Kost-Alimova, Patrick Byrne, Beth Cimini, Makoto Fujiwara, Henry M. Kronenberg, Marc N. Wein
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
The molecular circuitry that drives dendrite formation during osteocytogenesis remains poorly understood. Here the authors show that deletion of Sp7, a gene linked to rare and common skeletal disease, in mature osteoblasts and osteocytes causes sever
Externí odkaz:
https://doaj.org/article/cd91057df8104b6bb42af0b42b4a9105
Autor:
Josephine H. Li, Lauren E. Hanley, Camille E. Powe, Jacqueline A. Seiglie, Melanie S. Haines, Marc N. Wein, Amy Bregar, Karen K. Miller, Laura E. Dichtel
Publikováno v:
Journal of Clinical and Translational Science, Vol 7 (2023)
Physician parents encounter unique challenges in balancing new parenthood with work responsibilities, especially upon their return from parental leave. We designed a pilot program that incorporated 1:1 parental coaching to expectant and new physician
Externí odkaz:
https://doaj.org/article/96b8f425dca34855b77b9d21d2c365e0
Autor:
Courtney M. Mazur, Christian D. Castro Andrade, Nicha Tokavanich, Tadatoshi Sato, Michael Bruce, Daniel J. Brooks, Mary L. Bouxsein, Jialiang S. Wang, Marc N. Wein
Publikováno v:
iScience, Vol 25, Iss 9, Pp 105019- (2022)
Summary: Glucocorticoid excess suppresses osteocyte remodeling of surrounding bone minerals, causes apoptosis of osteoblasts and osteocytes, and disrupts bone remodeling, eventually, leading to glucocorticoid-induced osteoporosis and bone fragility.
Externí odkaz:
https://doaj.org/article/a868c96fea884ddfb757b78b880b95da
Autor:
Tadatoshi Sato, Shiv Verma, Christian D. Castro Andrade, Maureen Omeara, Nia Campbell, Jialiang S. Wang, Murat Cetinbas, Audrey Lang, Brandon J. Ausk, Daniel J. Brooks, Ruslan I. Sadreyev, Henry M. Kronenberg, David Lagares, Yuhei Uda, Paola Divieti Pajevic, Mary L. Bouxsein, Ted S. Gross, Marc N. Wein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Osteocytes are mechanoresponsive within skeletal tissue. Here, the authors show that class IIa histone deacetylases are phosphorylated by focal adhesion kinase, suggesting that HDAC5 may propagate mechanobiological cues to regulate cell type-specific
Externí odkaz:
https://doaj.org/article/28efc06b6072451db15433775595a921
Publikováno v:
Frontiers in Dental Medicine, Vol 2 (2021)
Appropriate tooth root formation and tooth eruption are critical for achieving and maintaining good oral health and quality of life. Tooth eruption is the process through which teeth emerge from their intraosseous position to their functional positio
Externí odkaz:
https://doaj.org/article/3d0f434ae7b144ebb2bf19161a618499
Autor:
Cheng-Chia Tang, Christian D Castro Andrade, Maureen J O'Meara, Sung-Hee Yoon, Tadatoshi Sato, Daniel J Brooks, Mary L Bouxsein, Janaina da Silva Martins, Jinhua Wang, Nathanael S Gray, Barbara Misof, Paul Roschger, Stephane Blouin, Klaus Klaushofer, Annegreet Velduis-Vlug, Yosta Vegting, Clifford J Rosen, Daniel O'Connell, Thomas B Sundberg, Ramnik J Xavier, Peter Ung, Avner Schlessinger, Henry M Kronenberg, Rebecca Berdeaux, Marc Foretz, Marc N Wein
Publikováno v:
eLife, Vol 10 (2021)
Bone formation and resorption are typically coupled, such that the efficacy of anabolic osteoporosis treatments may be limited by bone destruction. The multi-kinase inhibitor YKL-05–099 potently inhibits salt inducible kinases (SIKs) and may repres
Externí odkaz:
https://doaj.org/article/df0d71f913fb4c5a97707f2fd4b38a59
Autor:
Tadatoshi Sato, Shiv Verma, Ashok Khatri, Thomas Dean, Olga Goransson, Thomas J Gardella, Marc N Wein
Publikováno v:
JBMR Plus, Vol 5, Iss 5, Pp n/a-n/a (2021)
ABSTRACT Multiple analogs of parathyroid hormone, all of which bind to the PTH/PTHrP receptor PTH1R, are used for patients with osteoporosis and hypoparathyroidism. Although ligands such as abaloparatide, teriparatide (hPTH 1‐34 [TPTD]), and long
Externí odkaz:
https://doaj.org/article/c58b55467db54337808008379dc4512d