Výsledky vyhledávání - "N. Van Bruggen"

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RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

Publikováno v: Cell Death and Differentiation

Necroptosis is a caspase-independent form of cell death that is triggered by activation of the receptor interacting serine/threonine kinase 3 (RIPK3) and phosphorylation of its pseudokinase substrate mixed lineage kinase-like (MLKL), which then trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d4b49477ab1b9581c914016a9c96c5
https://doi.org/10.1038/cdd.2016.46

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Akademický článek

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Dynamic contrast-enhanced magnetic resonance imaging as a surrogate marker of tumor response to anti-angiogenic therapy in a xenograft model of glioblastoma multiforme

Autor: Thomas H. Helbich, Robert C. Brasch, Timothy P.L. Roberts, Axel Gossmann, Michael F. Wendland, Susanne Ostrowitzki, N. van Bruggen, Mark A. Israel, Nagato Kuriyama, David M. Shames

Publikováno v: Journal of Magnetic Resonance Imaging. 15:233-240

Purpose To evaluate the effects of a neutralizing anti-vascular endothelial growth factor (anti-VEGF) antibody on tumor microvascular permeability, a proposed indicator of angiogenesis, and tumor growth in a rodent malignant glioma model. Materials a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc92b048485b51963df3fe249a729e8b
https://doi.org/10.1002/jmri.10072

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Transient focal cerebral ischemia induces sensorimotor deficits in mice

Autor: Harold Thibodeaux, Robert Gerlai, M. van Lookeren Campagne, James T. Palmer, N. van Bruggen

Publikováno v: Behavioural Brain Research. 108:63-71

Rodents have been extensively used for experimental stroke research with rat and gerbil the preferred species. With the advent of transgenesis and gene targeting the number of mutant mouse strains is rapidly increasing. Thus, mouse models of stroke w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a018ae7058d0881de430296aa0508d3d
https://doi.org/10.1016/s0166-4328(99)00130-8

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Protein targeting in the analysis of learning and memory: a potential alternative to gene targeting

Autor: Paul Moran, Ingrid W. Caras, H S Phillips, Belinda Cairns, N. van Bruggen, John W. Winslow, Robert Gerlai, A. Shih, H Sauer, Simon-Peter Williams

Publikováno v: Experimental Brain Research. 123:24-35

Gene targeting using homologous recombination in embryonic stem (ES) cells offers unprecedented precision with which one may manipulate single genes and investigate the in vivo effects of defined mutations in the mouse. Geneticists argue that this te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2f585472d11bc0126d3b14499e46a1
https://doi.org/10.1007/s002210050541

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Magnetic Resonance Imaging of Propagating Waves of Spreading Depression in the Anaesthetised Rat

Autor: N. Van Bruggen, A. R. Gardner-Medwin, R. G. Ahier, Stephen R. Williams

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 14:7-11

Gradient echo magnetic resonance (MR) imaging was used to demonstrate propagating waves of cortical spreading depression (SD) in the anaesthetised rat. SD was initiated by remote perfusion with 150 m M KCl applied for 0.5–2 min to the left parietal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e29f5759b61f456d034608bc8fd0c3
https://doi.org/10.1038/jcbfm.1994.2

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Applications of magnetic resonance spectroscopy and diffusion-weighted imaging to the study of brain biochemistry and pathology

Autor: N. Van Bruggen, Risto A. Kauppinen, A.L. Busza, Stephen R. Williams

Publikováno v: Trends in Neurosciences. 16:88-95

The first practical demonstration that nuclear magnetic resonance (NMR) spectroscopy could be applied to the study of brain biochemistry in vivo came in 1980, with the studies of the rat brain using a surface coil. Since then the technique has been r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d802c2c4d3beda96d97992863183e2eb
https://doi.org/10.1016/0166-2236(93)90129-a

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