PO.6.127 Efavaleukin alfa, a novel IL-2 mutein, selectively expands regulatory t cells in patients with SLE: final results of a phase 1b multiple ascending dose study

Autor: R Zhang, C Stanley, X Hu, V Chow, N Tchao, R Furie, N Sarkar, C Milmont, Y Shi Jin, M Kroenke, K Gorski, K Alan

Publikováno v: Lupus Science and Medicine, Vol 9, Iss Suppl 2 (2022)

Externí odkaz: https://doaj.org/article/1e951f1a62ee4efb81121fa2000db0f1

Potentiality of Fractionated Extracts from Hemizygia welwitschii Rolfe-Ashby (Lamiaceae) Leaf to Protect Maize against Sitophilus zeamais Motschulsky (Coleoptera: Curculionidae) in Storage

Autor: M. C. Zourmba, M. N. Lakane, N. Tchao, T. Gangue, Elias Nchiwan Nukenine, T. G. Fotso, W. F. G. D. Kapche, D. J. Langsi

Publikováno v: European Journal of Nutrition & Food Safety. :68-80

Laboratory tests were conducted in order to assess the potential insecticidal effect of hexane, acetone and methanol fractionated extracts from Hemizygia welwitschii leaves against Sitophilus zeamais Motschulsky, important stored maize pest. The thre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18b14a5fad21795ddc9bd6df3251bf5a
https://doi.org/10.9734/ejnfs/2020/v12i1030303

THU0031 Phenotype of foxp3+ regulatory t-cells expanded by the il-2 mutein, amg 592 in healthy subjects in phase 1, first-in-human study

Autor: J. Stern, A. Anderson, Michael Boedigheimer, Y.-H. Hsu, Kevin S. Gorski, N. Tchao

Publikováno v: THURSDAY, 14 JUNE 2018.

Background Low-dose interleukin-2 (IL-2) therapy expands regulatory T cells (Treg) and provides clinical benefit for inflammatory diseases. AMG 592 is an investigational IL-2 mutein designed to expand Treg more selectively than recombinant IL-2 (alde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2c06fbc467f56083b7f07d0a4b78b44
https://doi.org/10.1136/annrheumdis-2018-eular.7212

A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging

Autor: Brady Olsen, Marc K. Ting, Simon C. Johnson, Annie Chou, Dennis Wang, Monika Jelic, Zhongjun Zhou, Dillon Pruett, Eric C. Liao, Sarani Goswami, Mitsuhiro Tsuchiya, Ariana A. Rodriguez, Arieanna C. Anies, Theodor K. Bammler, Elroy H. An, Sylvia Sim, Diana N. Pak, Kristan K. Steffen, Juniper K. Pennypacker, Kim M. Pham, Christopher F. Bennett, Helen Vander Wende, Richard M. Moller, Bopharoth Ros, Tom Pollard, Richard P. Beyer, Mark A. McCormick, Winston Lo, Joe R. Delaney, Jennifer Schleit, Shannon Klum, Diana Kim, Anthony S. Castanza, Rachel B. Brem, Ki Soo Jeong, Benjamin L. Spector, Daniel B. Carr, Brian M. Wasko, K. Linnea Welton, Eric A. Westman, Donna Prunkard, Scott Tsuchiyama, Katie Kirkland, Amrita Solanky, Dilreet Rai, Shiena Enerio, Christopher J. Murakami, Manpreet K. Singh, Marissa Fletcher, Anna Shemorry, George L. Sutphin, Elijah D. Johnston, Molly A. Holmberg, Zhao Jun Peng, Lindsay A. Fox, Sean Higgins, Yousin Suh, Michael Lim, Dan Lockshon, Jin Kim, Jessica Hui, Erica D. Smith, Eunice Choi, Brian Muller, Xinguang Liu, Soumya Kotireddy, Nick Dang, Hillary Miller, Prarthana Pradeep, Di Hu, Brett Robison, Brian K. Kennedy, Matt Kaeberlein, Katie Snead, Michael Sage, Emily O. Kerr, Michael S. Lin, Umema Ahmed, Bie N. Tchao, Jonathan A. Oakes, Adrienne M. Wang

Publikováno v: Cell metabolism. 22(5)

SummaryMany genes that affect replicative lifespan (RLS) in the budding yeast Saccharomyces cerevisiae also affect aging in other organisms such as C. elegans and M. musculus. We performed a systematic analysis of yeast RLS in a set of 4,698 viable s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19253045f4261307bf82da7d1a0ad114
https://pubmed.ncbi.nlm.nih.gov/26456335

Effects of Nasal Allergen Challenge on T cell signature in Peripheral Blood in Patients with Severe Seasonal Allergic Rhinitis

Autor: Mohamed H. Shamji, A. Togias, J.A. Leyhadi, V. Bellido, N. Tchao, Stephen R. Durham, M. Plaut, Moises A. Calderon, Guy W. Scadding, L. Turka, D. Phippard

Publikováno v: Journal of Allergy and Clinical Immunology. 129:AB196

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0d6b53dde3000ec83a0bc5a1b72f8ce
https://doi.org/10.1016/j.jaci.2011.12.295