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pro vyhledávání: '"N. Sumru Bayin"'
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Autor:
Reeti Mayur Sanghrajka, Richard Koche, Hector Medrano, Salsabiel El Nagar, Daniel N. Stephen, Zhimin Lao, N. Sumru Bayin, Kai Ge, Alexandra L. Joyner
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107831- (2023)
Summary: The major cause of treatment failure and mortality among medulloblastoma patients is metastasis intracranially or along the spinal cord. The molecular mechanisms driving tumor metastasis in Sonic hedgehog-driven medulloblastoma (SHH-MB) pati
Externí odkaz:
https://doaj.org/article/0ff602ca0cc44d9cb6da3c5af8918d2e
Autor:
Harikrishna Rallapalli, N. Sumru Bayin, Hannah Goldman, Dragan Maric, Brian J. Nieman, Alan P. Koretsky, Alexandra L. Joyner, Daniel H. Turnbull
Publikováno v:
NeuroImage, Vol 276, Iss , Pp 120198- (2023)
Magnetic Resonance Imaging (MRI) resolution continues to improve, making it important to understand the cellular basis for different MRI contrast mechanisms. Manganese-enhanced MRI (MEMRI) produces layer-specific contrast throughout the brain enablin
Externí odkaz:
https://doaj.org/article/f5291e0394464c1ea3b1b8d620ae031f
Autor:
Haidong Huang, Jennifer S. Yu
Publikováno v:
Neoplasia (New York, N.Y.)
High-grade glioma (HGG), a deadly primary brain malignancy, manifests radioresistance mediated by cell-intrinsic and microenvironmental mechanisms. High levels of the cytokine transforming growth factor-β (TGF-β) in HGG promote radioresistance by e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4ca972fcb38d8af182eb5d155a821d
https://doi.org/10.1016/j.neo.2016.10.009
https://doi.org/10.1016/j.neo.2016.10.009
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Externí odkaz:
https://doaj.org/article/1ebffb0792824d1eb749fc0a120b7c42
Publikováno v:
Cell. 186:1295-1299
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7c21ddef7f393801effdb8f41892ebb
https://doi.org/10.1016/j.cell.2023.03.002
https://doi.org/10.1016/j.cell.2023.03.002
Autor:
Alexandra L. Joyner, N. Sumru Bayin
Publikováno v:
Development (Cambridge, England). 149(18)
ABSRACT The cerebellum has a simple cytoarchitecture consisting of a folded cortex with three cell layers that surrounds a nuclear structure housing the output neurons. The excitatory neurons are generated from a unique progenitor zone, the rhombic l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f083b6b7578e003afa0960ae37c8d44e
https://pubmed.ncbi.nlm.nih.gov/36172987
https://pubmed.ncbi.nlm.nih.gov/36172987
Autor:
Aram S. Modrek, Danielle Golub, Themasap Khan, Devin Bready, Jod Prado, Christopher Bowman, Jingjing Deng, Guoan Zhang, Pedro P. Rocha, Ramya Raviram, Charalampos Lazaris, James M. Stafford, Gary LeRoy, Michael Kader, Joravar Dhaliwal, N. Sumru Bayin, Joshua D. Frenster, Jonathan Serrano, Luis Chiriboga, Rabaa Baitalmal, Gouri Nanjangud, Andrew S. Chi, John G. Golfinos, Jing Wang, Matthias A. Karajannis, Richard A. Bonneau, Danny Reinberg, Aristotelis Tsirigos, David Zagzag, Matija Snuderl, Jane A. Skok, Thomas A. Neubert, Dimitris G. Placantonakis
Publikováno v:
Cell Reports, Vol 21, Iss 5, Pp 1267-1280 (2017)
Summary: Low-grade astrocytomas (LGAs) carry neomorphic mutations in isocitrate dehydrogenase (IDH) concurrently with P53 and ATRX loss. To model LGA formation, we introduced R132H IDH1, P53 shRNA, and ATRX shRNA into human neural stem cells (NSCs).
Externí odkaz:
https://doaj.org/article/6c38719ab387499d9cbeaef12ccef89b
Autor:
Ryan T Willett, N Sumru Bayin, Andrew S Lee, Anjana Krishnamurthy, Alexandre Wojcinski, Zhimin Lao, Daniel Stephen, Alberto Rosello-Diez, Katherine L Dauber-Decker, Grant D Orvis, Zhuhao Wu, Marc Tessier-Lavigne, Alexandra L Joyner
Publikováno v:
eLife, Vol 8 (2019)
For neural systems to function effectively, the numbers of each cell type must be proportioned properly during development. We found that conditional knockout of the mouse homeobox genes En1 and En2 in the excitatory cerebellar nuclei neurons (eCN) l
Externí odkaz:
https://doaj.org/article/dac5953036a24d41a919545b03161f3f
Autor:
N Sumru Bayin, Alexandre Wojcinski, Aurelien Mourton, Hiromitsu Saito, Noboru Suzuki, Alexandra L Joyner
Publikováno v:
eLife, Vol 7 (2018)
Outside of the neurogenic niches of the brain, postmitotic neurons have not been found to undergo efficient regeneration. We demonstrate that mouse Purkinje cells (PCs), which are born at midgestation and are crucial for development and function of c
Externí odkaz:
https://doaj.org/article/0d3997780886410a8199e611bd72599a