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Akademický článek

Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence

Autor: Eva Latorre, Vishal C. Birar, Angela N. Sheerin, J. Charles C. Jeynes, Amy Hooper, Helen R. Dawe, David Melzer, Lynne S. Cox, Richard G. A. Faragher, Elizabeth L. Ostler, Lorna W. Harries

Publikováno v: BMC Cell Biology, Vol 18, Iss 1, Pp 1-15 (2017)

Abstract Background Altered expression of mRNA splicing factors occurs with ageing in vivo and is thought to be an ageing mechanism. The accumulation of senescent cells also occurs in vivo with advancing age and causes much degenerative age-related p

Externí odkaz: https://doaj.org/article/717f49a517e94b39be55597aba23e861

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O049 Interleukin-16 in flush effluent fluid as a biomarker for kidney viability prior to transplantation

Autor: J Dobbins, G Cheemungtoo, S Tingle, B Mahendran, L Bates, A Amer, G Sen, J Hammond, R Figueiredo, D Talbot, D Manas, S White, N Sheerin, S Ali, C Wilson

Publikováno v: British Journal of Surgery. 110

Background Kidney transplantation is limited by the number of transplantable organs. Biomarkers that can predict organ viability will reduce the number of organs currently discarded (13% UK, 2021-22, NHSBT). The kidney microcirculation can be flushed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38486c6f24f90244d4c9f0e582c433d6
https://doi.org/10.1093/bjs/znad101.049

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O041 Recipient outcomes after simultaneous pancreas and kidney transplant delineated by donor EGFR

Autor: R Owen, N Fitzpatrick, C Counter, A Malik, B Mahendran, S Tingle, C Wilson, D Manas, N Sheerin, S White

Publikováno v: British Journal of Surgery. 110

Introduction This study aimed to assess if the use of kidneys from donors with a decreased eGFR had an adverse effect on patient and graft survival. Methods Data on all UK SPKT's from 2001-2021 were obtained from the NHSBT UK Transplant Registry (n=2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b447308203cbfc6652a0da46d3601aeb
https://doi.org/10.1093/bjs/znad101.041

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O043 Evaluation of minimal factor H therapy administered to kidneys during ex vivo normothermic perfusion as a treatment to improve ischaemia reperfusion injury

Autor: C Connelly, B Gibson, B Mahendran, S J Tingle, L Bates, M Cooper, E Thompson, C Wilson, N Sheerin, K Marchbank

Publikováno v: British Journal of Surgery. 110

Introduction Complement activation is a key mechanism of Ischaemia reperfusion injury, with the alternative pathway driving damage in particular. The main regulator of the alternative pathway is factor H. We hypothesised that homodimeric mini-factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5dc9ae91e6c136eb7d9b5e553b522ef3
https://doi.org/10.1093/bjs/znad101.043

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O030 Image-analysis algorithm to determine quality of cold perfusion in kidney transplantation

Autor: SJ Tingle, ER Thompson, L Bates, C Connelly, S Colenutt, M Turner, H Ugail, R Hodgetts, BM Thomson, N Sheerin, C Wilson

Publikováno v: British Journal of Surgery. 109

Introduction Surgeon assessment of visual ‘quality of perfusion’ (QOP) influences kidney discard and predicts transplant outcome. However, this assessment is subjective and bias-prone. We aimed to design an application utilising a smartphone came

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c21811efd65e58436d0dd5582f93c4c
https://doi.org/10.1093/bjs/znac242.030

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Introducing an Enhanced Recovery After Surgery (ERAS) programme within the field of renal transplantation – The early newcastle experience

Autor: C. Scuffell, K. Ashton, J. Houston, A. Telford, F. Dowen, K. Kotur, N. Sheerin, D. Manas, A. Amer

Publikováno v: Clinical Nutrition ESPEN. 51:494-495

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b75a70a2d90e9ff90b73430ba978bbf8
https://doi.org/10.1016/j.clnesp.2022.06.024

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POS-052 TWO PHASE III TRIALS EVALUATING CROVALIMAB IN PATIENTS WITH ATYPICAL HAEMOLYTIC URAEMIC SYNDROME (aHUS): COMMUTE-a and COMMUTE-p

Autor: N. Sheerin, L.A. Greenbaum, I. Shuichi, C. Loirat, S. Maruyama, M.H. Zhao, K. Benkali, C. Pieterse, M.D. Shah, A. Sostelly, S. Sreckovic, F. Fakhouri

Publikováno v: Kidney International Reports. 7:S460-S461

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6013e5edfc17f82960f9cc16c1ba4210
https://doi.org/10.1016/j.ekir.2022.04.074

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Classification of Lung Tuberculosis using Non Parametric and Deep Neural Network Techniques

Autor: S. Kavitha, N. Sheerin Sitara, S. Poornima, A. Sarada Devi

Publikováno v: 2020 4th International Conference on Computer, Communication and Signal Processing (ICCCSP).

Intelligent systems are emerging rapidly to mimic the learning capability of human brain. These systems are developed to learn, adapt, act and make decisions autonomously based on the problem, commonly named as Computer Aided Disease Diagnosis (CAD).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f666f07bfa44a15b4c2017c1d78c184f
https://doi.org/10.1109/icccsp49186.2020.9315211

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