Zobrazeno 1 - 10
of 12
pro vyhledávání: '"N. Shane Cutler"'
Autor:
Kevin Chung, Philip J. Moos, John M. Veranth, David W. Woessner, Matthew Honeggar, N. Shane Cutler
Publikováno v:
Chemical Research in Toxicology. 23:733-739
There is ongoing concern regarding the toxicity of nanoparticles with sizes less than 100 nm as compared to larger particles of the same nominal substance. Two commercial ZnO types, one sold as a 8-10 nm powder and the other described as -325 mesh (4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89acdcf0edb9422185c65623cae38c86
https://doi.org/10.1021/tx900203v
https://doi.org/10.1021/tx900203v
Publikováno v:
Drug Metabolism and Disposition. 33:1174-1184
Lung-selective cytochrome P450 expression is well recognized; however, little is known regarding regulatory mechanisms. To address this knowledge gap, transient expression of CYP4B1/luciferase constructs was used to identify a proximal, positively ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59dfe127a6aa8dc799fdc906b65ee05
https://doi.org/10.1124/dmd.105.004523
https://doi.org/10.1124/dmd.105.004523
Publikováno v:
Genes & Development. 13:3271-3279
Rapamycin inhibits the TOR kinases, which regulate cell proliferation and mRNA translation and are conserved from yeast to man. The TOR kinases also regulate responses to nutrients, including sporulation, autophagy, mating, and ribosome biogenesis. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38fdd9c3ec6d19fccb81ed3f74da2fdf
https://doi.org/10.1101/gad.13.24.3271
https://doi.org/10.1101/gad.13.24.3271
Publikováno v:
Molecular and Cellular Endocrinology. 155:135-142
Rapamycin is a natural product with potent antifungal and immunosuppressive activities. Rapamycin binds to the FKBP12 prolyl isomerase, and the resulting protein-drug complex inhibits the TOR kinase homologs. Both the FKBP12 and the TOR proteins are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d593ff45d39a1423ec986b25265d7bfa
https://doi.org/10.1016/s0303-7207(99)00121-5
https://doi.org/10.1016/s0303-7207(99)00121-5
Publikováno v:
Trends in Biotechnology. 16:427-433
Many bacteria and fungi produce natural products that are toxic to other microorganisms and have a variety of physiological effects in animals. Recent studies have revealed that, in several cases, the targets of these agents are components of conserv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c062b21cc71a70b583f9736a12bade
https://doi.org/10.1016/s0167-7799(98)01239-6
https://doi.org/10.1016/s0167-7799(98)01239-6
Cultured lung cells provide an alternative to animal exposures for comparing the effects of different types of air pollution particles. Studies of particulate matter in vitro have reported proinflammatory cytokine signaling in response to many types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915249e71a4e5c88e6f91694a5e731e1
https://europepmc.org/articles/PMC2464571/
https://europepmc.org/articles/PMC2464571/
Autor:
Jukka Hakkola, Jason S. Biggs, Hannu Raunio, Päivi Uusimäki, N. Shane Cutler, Garold S. Yost, Jie Wan
Publikováno v:
Molecular pharmacology. 72(3)
Two vital enzymes of the CYP3A subfamily, CYP3A4 and CYP3A5, are differentially expressed in the human lung. However, the molecular mechanisms that regulate tissue-selective expression of the genes are poorly understood. The ability of the 5' upstrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14baced92163565f307caa56d61a60d
https://pubmed.ncbi.nlm.nih.gov/17548528
https://pubmed.ncbi.nlm.nih.gov/17548528
Autor:
Susan G. Campbell, N. Shane Cutler, Maria E. Cardenas, John R. Rohde, Sara A. Zurita-Martinez, Mark P. Ashe
Publikováno v:
Molecular and cellular biology. 24(19)
The Tor kinases are the targets of the immunosuppressive drug rapamycin and couple nutrient availability to cell growth. In the budding yeast Saccharomyces cerevisiae, the PP2A-related phosphatase Sit4 together with its regulatory subunit Tap42 media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b736b19a8d959cf8a5d8901c74e841a
https://pubmed.ncbi.nlm.nih.gov/15367655
https://pubmed.ncbi.nlm.nih.gov/15367655
Autor:
N Shane, Cutler, Ramona, Graves-Deal, Bonnie J, LaFleur, Zhenqiang, Gao, Bruce M, Boman, Robert H, Whitehead, Erin, Terry, Jason D, Morrow, Robert J, Coffey
Publikováno v:
Cancer research. 63(8)
The mechanism whereby cyclooxygenase-2 and its prostaglandin (PG) products are involved in colonic carcinogenesis is not fully understood. Prostacyclin (PGI(2)) is a major PG with antiapoptotic activity and is produced in the gastrointestinal tract.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::779ad8ee62daf8ea2807db7e1f356293
https://pubmed.ncbi.nlm.nih.gov/12702555
https://pubmed.ncbi.nlm.nih.gov/12702555
Publikováno v:
Molecular biology of the cell. 12(12)
Rapamycin binds and inhibits the Tor protein kinases, which function in a nutrient-sensing signal transduction pathway that has been conserved from the yeast Saccharomyces cerevisiaeto humans. In yeast cells, the Tor pathway has been implicated in re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cece3db678977f0bf364f8e5091488e5
https://pubmed.ncbi.nlm.nih.gov/11739804
https://pubmed.ncbi.nlm.nih.gov/11739804