Zobrazeno 1 - 9 of 9 pro vyhledávání: '"N. Seth Linde"'
1
Akademický článek
Fertility-preserving myeloablative conditioning using single-dose CD117 antibody-drug conjugate in a rhesus gene therapy model
Autor: Naoya Uchida, Ulana Stasula, Selami Demirci, Paula Germino-Watnick, Malikiya Hinds, Anh Le, Rebecca Chu, Alexander Berg, Xiong Liu, Ling Su, Xiaolin Wu, Allen E. Krouse, N. Seth Linde, Aylin Bonifacino, So Gun Hong, Cynthia E. Dunbar, Leanne Lanieri, Anjali Bhat, Rahul Palchaudhuri, Bindu Bennet, Megan Hoban, Kirk Bertelsen, Lisa M. Olson, Robert E. Donahue, John F. Tisdale
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Hematopoietic stem cell (HSC) gene therapy has curative potential; however, its use is limited by the morbidity and mortality associated with current chemotherapy-based conditioning. Targeted conditioning using antibody-drug conjugates (ADC)
Externí odkaz: https://doaj.org/article/da5777a8fdb54d1094c35c66359052e6
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2
Akademický článek
Preclinical evaluation for engraftment of CD34+ cells gene-edited at the sickle cell disease locus in xenograft mouse and non-human primate models
Autor: Naoya Uchida, Linhong Li, Tina Nassehi, Claire M. Drysdale, Morgan Yapundich, Jackson Gamer, Juan J. Haro-Mora, Selami Demirci, Alexis Leonard, Aylin C. Bonifacino, Allen E. Krouse, N. Seth Linde, Cornell Allen, Madhusudan V. Peshwa, Suk See De Ravin, Robert E. Donahue, Harry L. Malech, John F. Tisdale
Publikováno v: Cell Reports Medicine, Vol 2, Iss 4, Pp 100247- (2021)
Summary: Sickle cell disease (SCD) is caused by a 20A > T mutation in the β-globin gene. Genome-editing technologies have the potential to correct the SCD mutation in hematopoietic stem cells (HSCs), producing adult hemoglobin while simultaneously e
Externí odkaz: https://doaj.org/article/8e26d04f631d48acaf229ebbbd2bce17
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4
Sustained fetal hemoglobin induction in vivo is achieved by
Autor: Naoya, Uchida, Francesca, Ferrara, Claire M, Drysdale, Morgan, Yapundich, Jackson, Gamer, Tina, Nassehi, Julia, DiNicola, Yoshitaka, Shibata, Matthew, Wielgosz, Yoon-Sang, Kim, Matthew, Bauler, Robert E, Throm, Juan J, Haro-Mora, Selami, Demirci, Aylin C, Bonifacino, Allen E, Krouse, N Seth, Linde, Robert E, Donahue, Byoung, Ryu, John F, Tisdale
Publikováno v: Science translational medicine. 13(591)
Hematopoietic stem cell gene therapy for hemoglobin disorders, including sickle cell disease, requires high-efficiency lentiviral gene transfer and robust therapeutic globin expression in erythroid cells. Erythropoietin is a key cytokine for erythroi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f7d4c09f92cfc16e828243b01c520df5
https://pubmed.ncbi.nlm.nih.gov/33910976
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5
CD117 Antibody Drug Conjugate-Based Conditioning Allows for Efficient Engraftment of Gene-Modified CD34+ Cells in a Rhesus Gene Therapy Model
Autor: Naoya Uchida, Ulana Stasula, Malikiya Hinds, Paula Germino-Watnick, Allen E. Krouse, N Seth Linde, Aylin C. Bonifacino, Kellie Latimer, Prashant Bhattarai, Nicholas C. Yoder, Rahul Palchaudhuri, Qing Li, Kirk Bertelsen, Lisa Olson, Robert E. Donahue, John F. Tisdale
Publikováno v: Blood. 138:560-560
Hematopoietic stem cell (HSC) gene therapy is now curative for multiple genetic diseases; however, it is limited by morbidity and mortality from cytotoxic chemotherapy-based conditioning. To overcome these limitations, we developed an antibody drug c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01da03f69c24ac8d5a547b8b5a01ba43
https://doi.org/10.1182/blood-2021-145524
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8
Akademický článek
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9
Akademický článek
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