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Akademický článek

THE EXPRESSION OF TLR4, IFN-γ, TGF-β AND TNF-αLL LINE OF HUMAN SMALL CELL LUNG CARCINOMA NCI-H69 AND IN CISPLATIN-RESISTANT SUBLINE NCI-H69/CPR

Autor: I. Stupak, O. Gorbach, O. Sckachkova, N. Senchylo, E. Singayivskiy, M. Starshinova, L. Garmanchuk

Publikováno v: Biotechnologia Acta, Vol 15, Iss 6, Pp 55-60 (2022)

Aim: to investigate the effect of teichoic acid Staphylococcus aureus for expression of pro-inflammatory cytokines and of TLR4 in a human small cell lung carcinoma cell line NCI-H69, and cisplatin resistant subline NCI-H69/CPR. Methods. Incubation

Externí odkaz: https://doaj.org/article/dbf20afe477148dfab123021aaee7d0a

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Akademický článek

The effect of intranasally administered TLR3 agonist larifan on metabolic profile of microglial cells in rat with C6 glioma

Autor: Y. Hurmach, M. Rudyk, V. Svyatetska, N. Senchylo, O. Skachkova, D. Pjanova, K. Vaivode, L. Skivka

Publikováno v: The Ukrainian Biochemical Journal, Vol 90, Iss 6, Pp 110-119 (2018)

Glioma-associated microglia/macrophages (GAM) represent an attractive therapeutic target for the development of the alternative methodology in the treatment of gliomas. This study was aimed to investigate the effect of intranasally administered TLR3

Externí odkaz: https://doaj.org/article/6b6e01e112f74b39a44d548933840acb

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Reactive astrogliosis in rats with LPS-induced Parkinson's disease

Autor: M. Guzik, N. Senchylo, S. Stepanenko, T. Dovbynchuk, Zh. Oliynyk

Publikováno v: Bulletin of Taras Shevchenko National University of Kyiv. Series: Biology. 80:19-25

The astrogliosis was considered as a beneficial process to protect neurons and repair the tissue after CNS insult for a long time. However, numerous study indicate that under some specific conditions, reactive astrocytes can exacerbate neuroinflammat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0ca20bf2c114f56da0bf901ccecb595
https://doi.org/10.17721/1728_2748.2020.80.19-25

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Teichoic acid differentially modulates TLR4 expression in sensitive and resistant to cisplatin

Autor: P G Yakovlev, T. D. Skaterna, Liudmyla Drobot, N. Senchylo, L. V. Garmanchuk, O I Gorbach, L. Dubovtseva, O V Skachkova

Publikováno v: Bulletin of Taras Shevchenko National University of Kyiv. Series: Biology. 79:90-94

The Toll-like receptor family plays crucial role in the innate immune system, recognizing the molecular structures associated with pathogens derived from different microbes. TLRs also recognize the molecular structures associated with damage associat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::167b97d4ce0a2abda55b2df8fb54a1f3
https://doi.org/10.17721/1728_2748.2019.79.90-94

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Expression of TLR4 and major inflammatory cytokines in patients with bladder cancer of different grade and stage

Autor: N. Senchylo, P G Yakovlev, N. M. Khranovska, O V Skachkova, L. V. Garmanchuk, O I Gorbach, Liudmyla Ostapchenko

Publikováno v: Experimental oncology. 43(2)

Background The bladder cancer is immunogenic, and neoantigens generated by tumor cells trigger a notable immune response in the host. On the other hand, multiple immune escape mechanisms allow for avoiding the recognition by the host immune system. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d57a10017835c4bf726d6fd630e866fa
https://pubmed.ncbi.nlm.nih.gov/34190522

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The effect of intranasally administered TLR3 agonist larifan on metabolic profile of microglial cells in rat with C6 glioma

Autor: N. Senchylo, Larysa Skivka, O. Skachkova, Y. Hurmach, V. Svyatetska, Kristine Vaivode, M. Rudyk, Dace Pjanova

Publikováno v: Ukrainian Biochemical Journal, Vol 90, Iss 6, Pp 110-119 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e5daafc147d4bb720800400d1b9caf
http://ukrbiochemjournal.org/wp-content/uploads/2018/11/Hurmach_6.pdf

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Bacteriophage-derived dsRNA of natural origin alters functional profile of rat microglial cells exposed to hypoxia in vitro: Evaluation of metabolic and phenotypic markers

Autor: Guna Feldmane, Dace Pjanova, N. Senchylo, V. Svyatetska, Y. Hurmach, Larysa Skivka, Yehor Pashkevych, M. Rudyk

Publikováno v: Meta Gene. 17:S22

Background Microglial cells (MC) are thought to be major innate immune cells in the central nervous system. Hypoxia can cause pro- and anti-inflammatory MC activation. Toll-like receptors (TLRs) play an important role in the regulation of microglia a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2eb17a528488ca0b311669d9b42ac5d
https://doi.org/10.1016/j.mgene.2018.05.034

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