Zobrazeno 1 - 6
of 6
pro vyhledávání: '"N. Scott Blair"'
Autor:
Jiuzhou Huo, Vikram Prasad, Kelly M. Grimes, Davy Vanhoutte, N. Scott Blair, Suh-Chin Lin, Michael J. Bround, Donald M. Bers, Jeffery D. Molkentin
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113465- (2023)
Summary: Mitochondria use the electron transport chain to generate high-energy phosphate from oxidative phosphorylation, a process also regulated by the mitochondrial Ca2+ uniporter (MCU) and Ca2+ levels. Here, we show that MCUb, an inhibitor of MCU-
Externí odkaz:
https://doaj.org/article/b65c0ce78b7040798c4078208b4eb116
Autor:
Tetsuya Okada, Jeffrey Robbins, Jeffrey M. Lynch, Ron Prywes, Kaari A. Lynch, Davy Vanhoutte, Michelle A. Sargent, Jack Lawler, Kazutoshi Mori, Aryn Schloemer, Hanna Osinska, Jeffery D. Molkentin, N. Scott Blair, Bruce J. Aronow, John N. Lorenz, Marjorie Maillet
Publikováno v:
Cell. 149:1257-1268
Thrombospondin (Thbs) proteins are induced in sites of tissue damage or active remodeling. The endoplasmic reticulum (ER) stress response is also prominently induced with disease where it regulates protein production and resolution of misfolded prote
Autor:
Michelle A. Sargent, Tobias G. Schips, Bryan D. Maliken, Onur Kanisicak, Jeffery D. Molkentin, N. Scott Blair, Jason Karch, Vikram Prasad, Matthew J. Brody, Davy Vanhoutte
Thrombospondins are a family of stress-inducible secreted glycoproteins that underlie tissue remodeling. We recently reported that thrombospondin-4 (Thbs4) has a critical intracellular function, regulating the adaptive endoplasmic reticulum (ER) stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313611a5ff99746942e32018f257de33
https://europepmc.org/articles/PMC4702604/
https://europepmc.org/articles/PMC4702604/
Autor:
Jeffery D. Molkentin, Jeffrey Robbins, Nicole H. Purcell, Michael Hambleton, Gerald W. Dorn, N. Scott Blair, M. Richard Sayen, Hanna Osinska, Eric W. Brunskill, Roberta A. Gottlieb, Robert A. Kaiser, Christopher P. Baines
Publikováno v:
Nature. 434:658-662
Mitochondria play a critical role in mediating both apoptotic and necrotic cell death. The mitochondrial permeability transition (mPT) leads to mitochondrial swelling, outer membrane rupture and the release of apoptotic mediators. The mPT pore is tho
Publikováno v:
Circulation Research. 111
NFAT (Nuclear Factor of Activated T cells) transcriptions factors are directly activated by the Ca2+ activated serine-threonine protein phosphatase calcineurin. Following dephosphorylation, NFAT factors translocate to the nucleus. They share a Rel/NF
Autor:
Baojun Chang, Allen J. York, Michelle A. Sargent, Gary E. Shull, N. Scott Blair, Xu Wu, Jeffery D. Molkentin, Jeffrey Robbins
Publikováno v:
Journal of Clinical Investigation.
How Ca2+-dependent signaling effectors are regulated in cardiomyocytes, given the extreme cytoplasmic Ca2+ concentration changes that underlie contraction, remains unknown. Cardiomyocyte plasma membrane Ca2+-ATPase (PMCA) extrudes Ca2+ but has little