Zobrazeno 1 - 10
of 351
pro vyhledávání: '"N. Savvides"'
Autor:
Karel F. A. Van Damme, Pieter Hertens, Arne Martens, Elisabeth Gilis, Dario Priem, Inge Bruggeman, Amelie Fossoul, Jozefien Declercq, Helena Aegerter, Andy Wullaert, Tino Hochepied, Esther Hoste, Lieselotte Vande Walle, Mohamed Lamkanfi, Savvas N. Savvides, Dirk Elewaut, Bart N. Lambrecht, Geert van Loo
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract A20 serves as a critical brake on NF-κB-dependent inflammation. In humans, polymorphisms in or near the TNFAIP3/A20 gene have been linked to various inflammatory disorders, including systemic lupus erythematosus (SLE) and rheumatoid arthrit
Externí odkaz:
https://doaj.org/article/0bf2e4c99bae45e2afbc4924a4035aa2
Autor:
Nathaniel R. Bennett, Brian Coventry, Inna Goreshnik, Buwei Huang, Aza Allen, Dionne Vafeados, Ying Po Peng, Justas Dauparas, Minkyung Baek, Lance Stewart, Frank DiMaio, Steven De Munck, Savvas N. Savvides, David Baker
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract Recently it has become possible to de novo design high affinity protein binding proteins from target structural information alone. There is, however, considerable room for improvement as the overall design success rate is low. Here, we explo
Externí odkaz:
https://doaj.org/article/279adbbdbddf4e41bbd9f4a899f986cf
Autor:
Ines Heyndrickx, Kim Deswarte, Kenneth Verstraete, Koen HG Verschueren, Ursula Smole, Helena Aegerter, Ann Dansercoer, Hamida Hammad, Savvas N Savvides, Bart N Lambrecht
Publikováno v:
eLife, Vol 12 (2024)
Spontaneous protein crystallization is a rare event, yet protein crystals are frequently found in eosinophil-rich inflammation. In humans, Charcot-Leyden crystals (CLCs) are made from galectin-10 (Gal10) protein, an abundant protein in eosinophils. A
Externí odkaz:
https://doaj.org/article/027f2b940e04436392626839d4f1ade4
Autor:
Maximilian Brinkhaus, Erwin Pannecoucke, Elvera J. van der Kooi, Arthur E. H. Bentlage, Ninotska I. L. Derksen, Julie Andries, Bianca Balbino, Magdalena Sips, Peter Ulrichts, Peter Verheesen, Hans de Haard, Theo Rispens, Savvas N. Savvides, Gestur Vidarsson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Disrupting the association between the Immunoglobulin G constant fragment (Fc) and the neonatal Fc receptor (FcRn) by engineered antibodies is a promising strategy to reduce autoantibody levels in autoimmune diseases. Here authors show that the varia
Externí odkaz:
https://doaj.org/article/6899a98a2d164434bf23cc999f69e473
Autor:
Klaas Yperman, Anna C. Papageorgiou, Romain Merceron, Steven De Munck, Yehudi Bloch, Dominique Eeckhout, Qihang Jiang, Pieter Tack, Rosa Grigoryan, Thomas Evangelidis, Jelle Van Leene, Laszlo Vincze, Peter Vandenabeele, Frank Vanhaecke, Martin Potocký, Geert De Jaeger, Savvas N. Savvides, Konstantinos Tripsianes, Roman Pleskot, Daniel Van Damme
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
AtEH/Pan1 proteins contain two N-terminal Eps15 homology (EH) domains and are subunits of the endocytic TPLATE complex present in plants. Here, the authors combine X-ray crystallography, NMR and MD simulations with biochemical and in planta analysis
Externí odkaz:
https://doaj.org/article/54c36870e5d64914ba2d301548b4af42
Autor:
Conor Delaney, Michael Farrell, Colin P Doherty, Kiva Brennan, Eoin O’Keeffe, Chris Greene, Kieva Byrne, Eoin Kelly, Niamh Birmingham, Paula Hickey, Simon Cronin, Savvas N Savvides, Sarah L Doyle, Matthew Campbell
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 2, Pp 1-17 (2020)
Abstract Cerebrovascular pathologies occur in up to 80% of cases of Alzheimer's disease; however, the underlying mechanisms that lead to perivascular pathology and accompanying blood–brain barrier (BBB) disruption are still not fully understood. We
Externí odkaz:
https://doaj.org/article/9ed5f11fcad84fb6b9cf6cc689b7853f
Autor:
Flora D’Anna, Laurien Van Dyck, Jieyi Xiong, Hui Zhao, Rebecca V. Berrens, Junbin Qian, Pawel Bieniasz-Krzywiec, Vikas Chandra, Luc Schoonjans, Jason Matthews, Julie De Smedt, Liesbeth Minnoye, Ricardo Amorim, Sepideh Khorasanizadeh, Qian Yu, Liyun Zhao, Marie De Borre, Savvas N. Savvides, M. Celeste Simon, Peter Carmeliet, Wolf Reik, Fraydoon Rastinejad, Massimiliano Mazzone, Bernard Thienpont, Diether Lambrechts
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-36 (2020)
Abstract Background Hypoxia is pervasive in cancer and other diseases. Cells sense and adapt to hypoxia by activating hypoxia-inducible transcription factors (HIFs), but it is still an outstanding question why cell types differ in their transcription
Externí odkaz:
https://doaj.org/article/0d2e5621f90946fca225694fec6726cc
Autor:
Yves Dondelinger, Tom Delanghe, Dario Priem, Meghan A. Wynosky-Dolfi, Daniel Sorobetea, Diego Rojas-Rivera, Piero Giansanti, Ria Roelandt, Julia Gropengiesser, Klaus Ruckdeschel, Savvas N. Savvides, Albert J. R. Heck, Peter Vandenabeele, Igor E. Brodsky, Mathieu J. M. Bertrand
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
RIPK1 kinase activity is known to transduce a death signal, but the molecular mechanisms that normally prevent RIPK1 activation are unclear. Here, the authors report that IKK-mediated phosphorylation on RIPK1 Ser25 directly represses its enzymatic ac
Externí odkaz:
https://doaj.org/article/09b6a96e862a47278fdf07e7af978602
Autor:
Karolina Slowicka, Inmaculada Serramito-Gómez, Emilio Boada-Romero, Arne Martens, Mozes Sze, Ioanna Petta, Hanna K. Vikkula, Riet De Rycke, Eef Parthoens, Saskia Lippens, Savvas N. Savvides, Andy Wullaert, Lars Vereecke, Felipe X. Pimentel-Muiños, Geert van Loo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Maintaining the intestinal barrier function requires a balance of multiple signalling pathways. Here the authors show that A20, an anti-inflammatory and anti-apoptotic protein, and Atg1611, an autophagy regulator, cross-regulate their respective prot
Externí odkaz:
https://doaj.org/article/66f4ba80a7fd4950b7b10906aec986dc
Autor:
Alexandra Tsirigotaki, Ann Dansercoer, Koen H.G. Verschueren, Iva Marković, Christoph Pollmann, Maximillian Hafer, Jan Felix, Catherine Birck, Wouter Van Putte, Dominiek Catteeuw, Jan Tavernier, J. Fernando Bazan, Jacob Piehler, Savvas N. Savvides, Kenneth Verstraete
Publikováno v:
Nature Structural & Molecular Biology. 30:551-563
The adipokine Leptin activates its type I cytokine receptor (LEP-R) in the hypothalamus to regulate body weight and exerts additional pleiotropic functions in immunity, fertility, and cancer. However, the structure and mechanism of Leptin-mediated LE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3315c5a9b86da7b75aec3cf441b412e
https://doi.org/10.1038/s41594-023-00941-9
https://doi.org/10.1038/s41594-023-00941-9