Zobrazeno 1 - 10
of 1 272
pro vyhledávání: '"N. SHEPPARD"'
Autor:
Marta Vilà-González, Laetitia Pinte, Ricardo Fradique, Erika Causa, Heleen Kool, Mayuree Rodrat, Carola Maria Morell, Maha Al-Thani, Linsey Porter, Wenrui Guo, Ruhina Maeshima, Stephen L. Hart, Frank McCaughan, Alessandra Granata, David N. Sheppard, R. Andres Floto, Emma L. Rawlins, Pietro Cicuta, Ludovic Vallier
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background Pulmonary ionocytes have been identified in the airway epithelium as a small population of ion transporting cells expressing high levels of CFTR (cystic fibrosis transmembrane conductance regulator), the gene mutated in cystic fib
Externí odkaz:
https://doaj.org/article/6ef9e41560be48c89f72cdcceb53767c
Autor:
Carlos Bueno-Beti, PhD, Alessandro Tafuni, MD, Stephen P. Chelko, PhD, FHRS, Mary N. Sheppard, MD, Ella Field, MSc, Jennifer Tollit, MSc, Imogen K. Heenan, BSc, Annabelle Barnes, BSc, Matthew R. Taylor, MD, PhD, Luisa Mestroni, MD, Juan Pablo Kaski, MD, Jeffrey E. Saffitz, MD, PhD, FHRS, Angeliki Asimaki, PhD
Publikováno v:
Heart Rhythm O2, Vol 4, Iss 10, Pp 650-659 (2023)
Background: Nuclear factor κB (NF-κB) signaling in cardiac myocytes causes disease in a mouse model of arrhythmogenic cardiomyopathy (ACM) by mobilizing CCR2-expressing macrophages that promote myocardial injury and arrhythmias. Buccal mucosa cells
Externí odkaz:
https://doaj.org/article/69f01d83a22a45aeb9b4b55a5b34fdc1
Autor:
Samantha N. Sheppard, Travis Vogan
Despite the increasing number of popular and celebrated sports documentaries in contemporary culture, such as ESPN's 30 for 30 series, there has been little scholarly engagement with this genre. Sports documentaries, like all films, do not merely sho
Autor:
Alicja Urbaniak, Kenneth E. Thummel, Ayoade N. Alade, Allan E. Rettie, Bhagwat Prasad, Amedeo De Nicolò, Jennifer H. Martin, David N. Sheppard, Michael F. Jarvis
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 6, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/ea71230efd854459853282a653d1fadf
Autor:
Carlos Bueno‐Beti, Clarice X. Lim, Alexandros Protonotarios, Petra Lujza Szabo, Joseph Westaby, Mario Mazic, Mary N. Sheppard, Elijah Behr, Ouafa Hamza, Attila Kiss, Bruno K. Podesser, Markus Hengstschläger, Thomas Weichhart, Angeliki Asimaki
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 19 (2023)
Background Sarcoidosis is an inflammatory, granulomatous disease of unknown cause affecting multiple organs, including the heart. Untreated, unresolved granulomatous inflammation can lead to cardiac fibrosis, arrhythmias, and eventually heart failure
Externí odkaz:
https://doaj.org/article/ec6811c75eb84f1c881bd95ef1b7da1c
Publikováno v:
European Cardiology Review, Vol 18, Iss , Pp - (2023)
Cardiac implantable electronic devices are the cornerstone of cardiac rhythm management, with a significant number of implantations annually. A rising prevalence of cardiac implantable electronic devices coupled with widening indications for device r
Externí odkaz:
https://doaj.org/article/18e741fd6bcb4cd08a1475b78be20f5d
Autor:
Jennifer Kelly, Miran Al-Rammahi, Kristian Daly, Paul K. Flanagan, Arun Urs, Marta C. Cohen, Gabriella di Stefano, Marcel J. C. Bijvelds, David N. Sheppard, Hugo R. de Jonge, Ursula E. Seidler, Soraya P. Shirazi-Beechey
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Defective CFTR leads to accumulation of dehydrated viscous mucus within the small intestine, luminal acidification and altere
Externí odkaz:
https://doaj.org/article/839c5ac368f2469ea3deaf9f54353d59
Autor:
Martin K. Stiles, Arthur A. M. Wilde, Dominic J. Abrams, Michael J. Ackerman, Christine M. Albert, Elijah R. Behr, Sumeet S. Chugh, Martina C. Cornel, Karen Gardner, Jodie Ingles, Cynthia A. James, Jyh‐Ming Jimmy Juang, Stefan Kääb, Elizabeth S. Kaufman, Andrew D. Krahn, Steven A. Lubitz, Heather MacLeod, Carlos A. Morillo, Koonlawee Nademanee, Vincent Probst, Elizabeth V. Saarel, Luciana Sacilotto, Christopher Semsarian, Mary N. Sheppard, Wataru Shimizu, Jonathan R. Skinner, Jacob Tfelt‐Hansen, Dao Wu Wang
Publikováno v:
Journal of Arrhythmia, Vol 37, Iss 3, Pp 481-534 (2021)
Abstract This international multidisciplinary document intends to provide clinicians with evidence‐based practical patient‐centered recommendations for evaluating patients and decedents with (aborted) sudden cardiac arrest and their families. The
Externí odkaz:
https://doaj.org/article/c178f64f2c6147188a7773debe130bba
Autor:
Karen S. Raraigh, Kathleen C. Paul, Jennifer L. Goralski, Erin N. Worthington, Anna V. Faino, Stanley Sciortino, Yiting Wang, Melis A. Aksit, Hua Ling, Derek L. Osorio, Frankline M. Onchiri, Shivani U. Patel, Christian A. Merlo, Kristina Montemayor, Ronald L. Gibson, Natalie E. West, Amita Thakerar, Robert J. Bridges, David N. Sheppard, Neeraj Sharma, Garry R. Cutting
Publikováno v:
JCI Insight, Vol 7, Iss 6 (2022)
The chloride channel dysfunction caused by deleterious cystic fibrosis transmembrane conductance regulator (CFTR) variants generally correlates with severity of cystic fibrosis (CF). However, 3 adults bearing the common severe variant p.Phe508del (le
Externí odkaz:
https://doaj.org/article/78b4738b6909425d927439919d715df3
Autor:
Hariharan Raju, James S. Ware, Jonathan R. Skinner, Paula L. Hedley, Gavin Arno, Donald R. Love, Christian van der Werf, Jacob Tfelt-Hansen, Bo Gregers Winkel, Marta C. Cohen, Xinzhong Li, Shibu John, Sanjay Sharma, Steve Jeffery, Arthur A. M. Wilde, Michael Christiansen, Mary N. Sheppard, Elijah R. Behr
Publikováno v:
BMC Cardiovascular Disorders, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background We aimed to determine the mutation yield and clinical applicability of “molecular autopsy” following sudden arrhythmic death syndrome (SADS) by validating and utilizing low-cost high-throughput technologies: Fluidigm Access Ar
Externí odkaz:
https://doaj.org/article/dcacc9ba179d4d699a6d0ada9f7f32ac