Zobrazeno 1 - 10
of 25
pro vyhledávání: '"N. S. Shastina"'
Publikováno v:
Тонкие химические технологии, Vol 6, Iss 2, Pp 71-80 (2011)
In recent years, various approaches to the prodrug design on the basis of anti-HIV active nucleoside compounds used in the therapy are intensively investigated. In this paper, the principles of modifying this class of drugs by lipid substances allowi
Externí odkaz:
https://doaj.org/article/ac85836972ba4a5d858616a5573c3964
Effect of Lipid Components on Immunogenicity of Synthetic Fragment of Hepatitis C Virus NS4A Antigen
Autor:
A. N. Belyavtsev, N. S. Shastina, V. V. Kupriyanov, L. I. Nikolaeva, M. V. Melnikova, E. F. Kolesanova, M. Yu. Shimchishina, I. V. Kapustin
Publikováno v:
Russian Journal of Bioorganic Chemistry. 48:621-627
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc15ad98274a5120657607b47a73ecd0
https://doi.org/10.1134/s1068162022030049
https://doi.org/10.1134/s1068162022030049
Autor:
L I, Nikolaeva, A N, Belyavtsev, N G, Shevchenko, M D, Stuchinskaya, E I, Samokhvalov, A V, Dedova, G V, Sapronov, N S, Shastina, V V, Kuprianov
Publikováno v:
Voprosy virusologii. 67(3)
Chronic viral hepatitis C (CHC) is a ubiquitous infectious disease, a significant limitation of which WHO attributes to the use of a new highly effective antiviral therapy. Previously, two B-cell epitopes were identified in NS4a antigen of the hepati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::33e3fceb239837740cf03cc2e3469caf
https://pubmed.ncbi.nlm.nih.gov/35831966
https://pubmed.ncbi.nlm.nih.gov/35831966
Autor:
A. N. Belyavtsev, R. G. Vahrenev, E. F. Kolesanova, M. V. Melnikova, L. I. Nikolaeva, G. V. Sapronov, N. S. Shastina, N. G. Shevchenko
Publikováno v:
Russian Journal of Bioorganic Chemistry. 47:713-718
Abstract— The work is aimed at the synthesis and analysis from NS4A of hepatitis C virus (HCV) antigen peptide fragment that contains a conserved B-cell and T-helper epitopes. The 24-mer peptide VIVGRIILSGRPAVIPDREVLYRK-NH2, which contains the main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a08560faa27a50f67ac5f7cd40a1a9c2
https://doi.org/10.1134/s1068162021030031
https://doi.org/10.1134/s1068162021030031
Autor:
K. D. Kazarinov, E. Yu. Solov’eva, A. V. Chekanov, T. N. Fedorova, N. S. Shastina, V. A. Shchelkonogov, G. M. Sorokoumova, E. S. Darnotuk, A. I. Fedin, O. A. Baranova, S. L. Stvolinsky
Publikováno v:
Biophysics. 66:278-285
The conditions for producing phosphatidylcholine liposomes containing lipoic acid and carnosine together were determined. The obtained liposomes are 180–250-nm spherical particles with an efficiency of lipoic acid inclusion of 50–70% (for carnosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce818582e3e62cb35d0139a454471bd0
https://doi.org/10.1134/s0006350921020214
https://doi.org/10.1134/s0006350921020214
Publikováno v:
Medicinal Chemistry Research. 30:664-671
We report the synthesis of phosphoramidate conjugates of 3′-azido-3′-deoxythymidine (AZT) glycerolipid derivatives and amino acid esters. For the synthesized compounds, 50% inhibition of the HIV-1 MvP-899 strain in human T lymphoid MT-4 cells is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a40ff28d9ed50725b871f8c91a8604c
https://doi.org/10.1007/s00044-020-02672-8
https://doi.org/10.1007/s00044-020-02672-8
Autor:
A. V. Chekanov, E.Y. Solovieva, A.V. Shipelova, O. A. Baranova, A.M. Inshakova, A. I. Fedin, N. S. Shastina, K. D. Kazarinov, E. S. Darnotuk
Publikováno v:
http://eng.biomos.ru/conference/articles.htm. 1:101-104
Various nanodispersions (liposomes and nanoemulsions) with lipoic acid (LA) with size of particles 50-250 nm were obtained and characterized by 80±10% encapsulation efficiency (EI) of LA into NPs, its slow release from nanoconstructions, and possess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdc7d508015bda1cc1554476f748acfb
https://doi.org/10.37747/2312-640x-2021-19-101-104
https://doi.org/10.37747/2312-640x-2021-19-101-104
Autor:
E.Y. Solovieva, E. S. Darnotuk, A. M. Sinebryukhova, A.V. Shipelova, N. S. Shastina, A. V. Chekanov, A. I. Fedin, O. A. Baranova
Publikováno v:
BIOTECHNOLOGY: STATE OF THE ART AND PERSPECTIVES. :461-464
The optimal conditions were selected for obtaining homogeneous nanoemulsions (NE) of lipoic acid conjugates (LA-conjugates) based on Pluronic F68 (1,8%) with a particle size not exceeding 400 nm, characterized by 97±2% encapsulation efficiency of su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6adc06d38974d81ae5fba5b2fcb66a2c
https://doi.org/10.37747/2312-640x-2020-18-461-464
https://doi.org/10.37747/2312-640x-2020-18-461-464
Autor:
A. A. Selishcheva, N. S. Shastina, V. A. Shchelkogonov, E. A. Korepanova, A. V. Chekanov, Andrej A. Anosov, E. Yu. Solov’eva, N. Yu. Lotosh, R. A. Kamyshinskii, O. A. Baranova, S. O. Alyaseva, R. G. Vasilov
Publikováno v:
European Biophysics Journal. 49:95-103
We describe the dynamics of lipoic acid (LA) alone, incorporated in liposomes and as a part of nanoemulsions. Mass spectrometry shows that LA in water forms aggregates of two or three molecules in the form of a negatively charged ion and a neutral mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e40dd5f6edbd2e8bb7806dc2797b2b9
https://doi.org/10.1007/s00249-019-01415-x
https://doi.org/10.1007/s00249-019-01415-x
Autor:
Anna M. Inshakova, A. I. Fedin, N. S. Shastina, Vasiliy A. Shchelkonogov, Olga A. Baranova, A. V. Chekanov, Ella Yu. Solov'eva, Alina V. Shipelova
Publikováno v:
Mendeleev Communications. 31:507-508
Five lipoic acid esters were synthesized, and their nanoforms based on copolymer Pluronic F68 and phosphatidylcholine were obtained. The most pronounced antioxidant effect on neutrophils activated by phorbol-12-myristate-13-acetate was shown by the n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2211d45a40aaaee5cdbf9582a530b25
https://doi.org/10.1016/j.mencom.2021.07.023
https://doi.org/10.1016/j.mencom.2021.07.023