Výsledky vyhledávání - "N. S. Nicholson"

Design of orally active, non-peptide fibrinogen receptor antagonists: The evolution process from the RGD sequence to novel anti-platelet aggregation agents

Publikováno v: Peptides 1994 ISBN: 9789072199218

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::620b95f8fea5dddf6249efa11071a7a5
https://doi.org/10.1007/978-94-011-1468-4_25

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Biotinidase deficiency: early neurological presentation

Autor: J. V. Leonard, J. E. Collins, N. S. Nicholson, N. Dalton

Publikováno v: Developmental medicine and child neurology. 36(3)

Three patients with biotinidase deficiency are described. Two presented at eight weeks of age with anticonvulsant-resistant fits, developmental delay and hypotonia. Treatment has been effective. The third developed ataxia and alopecia at 14 months an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18923228091543eee095329370b7cfe8
https://pubmed.ncbi.nlm.nih.gov/8050627

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SC-49992, a mimetic of the peptide arginine-glycine-aspartic acid-phenylalanine that blocks platelet aggregation, enhances recombinant tissue plasminogen activator-induced thrombolysis and prevents reocclusion in a canine model of coronary artery thrombosis

Autor: L P, Feigen, N S, Nicholson, L W, King, J G, Campion, F S, Tjoeng, S G, Panzer-Knodle

Publikováno v: The Journal of pharmacology and experimental therapeutics. 267(3)

8-Guanidino-octanoyl-aspartic acid-phenylalanine (SC-49992), a mimetic of the tetrapeptide arginine-glycine-aspartic acid-phenylalanine, is a potent inhibitor of platelet aggregation. In this study, the authors examined the effects of SC-49992 on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::438efb2d09ecc2fc0ff0d018e12555bf
https://pubmed.ncbi.nlm.nih.gov/8263779

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Antiplatelet and antithrombotic effects of platelet glycoprotein IIb/IIIa (GPIIb/IIIa) inhibition by arginine-glycine-aspartic acid-serine (RGDS) and arginine-glycine-aspartic acid (RGD) (O-me)Y (SC-46749)

Autor: N S, Nicholson, S G, Panzer-Knodle, A K, Salyers, B B, Taite, L W, King, M, Miyano, R J, Gorczynski, M H, Williams, M E, Zupec, F S, Tjoeng

Publikováno v: The Journal of pharmacology and experimental therapeutics. 256(3)

Arginine-glycine-aspartic acid (RGD) is the minimal sequence in fibrinogen that leads to recognition and binding to the glycoprotein IIb/IIIa platelet receptor during aggregation. Analogs of tetrapeptides containing the RGD sequence have been previou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::686b4c0562c62c615086ca03b307c66f
https://pubmed.ncbi.nlm.nih.gov/2005585

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Evaluation of a stable 5-F prostacyclin analogue as an antithrombotic agent in haemodialysis

Autor: N S, Nicholson, S L, Smith, B B, Taite, A, Krueger, G C, Fuller

Publikováno v: Drugs under experimental and clinical research. 12(5)

Prostacyclin has been used as a substitute for heparin in renal dialysis because of its potent antiplatelet activity and its short half-life. However, it is difficult to use because of its instability in neutral buffer and its hypotensive activity at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef5fecc4600e5733a72885e758034fe4
https://pubmed.ncbi.nlm.nih.gov/3522158

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The Activity Of PhthalazinoL In Basic Platelet Function Tests

Autor: N S Nicholson, S L Smith, R N Saunders

Publikováno v: Oral Presentations.

Phthalazinol (EG-626, SC-32840) was evaluated in several basic platelet function tests in comparison with known antiplatelet agents. The IC50șs for collagen-, ADP-, and thrombin-induced aggregation of human platelets in vitro were 28, 51 and 88 µM,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40f62505d27f86a97426b77cefc9665b
https://doi.org/10.1055/s-0038-1653263

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Correlation Between Platelet Disaggregation And Arachidonic Acid Conversion To Prostacyclin And Thromboxane A2 In The Ex Vivo Cat Model

Autor: S L Smith, N S Nicholson, R N Saunders

Publikováno v: Oral Presentations.

Arachidonic Acid (AA) infusion in the ex vivo cat model was performed to determine the effects of the products produced from the metabolism of AA on the disaggregation of platelets accumulated on a rabbit Achilles tendon. Apparent peak blood levels o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4194ea514016b7be7805ff0e24442629
https://doi.org/10.1055/s-0038-1653374

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Sex Difference In Platelet Response To Aspirin Treatment

Autor: S L Smith, R N Saunders, N S Nicholson

Publikováno v: Oral Presentations.

This study was done to determine if a sex difference in response to aspirin similar to that seen in the clinic could be demonstrated in an animal model with hyperactive platelets. The platelet hyperactivity which results in the spontaneous formation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed53c1d6624449570b0df29e196bd11a
https://doi.org/10.1055/s-0038-1652094

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