Zobrazeno 1 - 10
of 38
pro vyhledávání: '"N. S. Gerasimova"'
Autor:
N. S. Gerasimova, A. N. Korovina, D. A. Afonin, K. V. Shaytan, A. V. Feofanov, V. M. Studitsky
Publikováno v:
Biophysics. 67:165-170
Autor:
N. V. Malyuchenko, Alexey V. Feofanov, D. O. Koshkina, Vasily M. Studitsky, N. S. Gerasimova, A. N. Korovina, Mikhail P. Kirpichnikov
Publikováno v:
Moscow University Biological Sciences Bulletin. 75:142-146
Gossypol is a highly active compound with antiviral, antioxidant, antimicrobial, antimalarial, and antitumor properties. It is known that the antitumor effect of gossypol is associated with genotoxicity; however, gossypol interaction with chromatin w
Publikováno v:
Moscow University Biological Sciences Bulletin. 74:246-249
Long-distance interaction plays an important role in the regulation of eukaryotic genes. Chromatin structure is involved in the process, but the role of histone modifications has not been studied. In the present work, the role of acetylation Н4K16 (
Autor:
Sohail Akhtar, John M. Pascal, N. S. Gerasimova, Elena Kotova, Mikhail P. Kirpichnikov, D. K. Nilov, Marie-France Langelier, Sergey Pushkarev, N. V. Maluchenko, Alexey V. Feofanov, Vasily M. Studitsky
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12127, p 12127 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 22
International Journal of Molecular Sciences
Volume 22
Issue 22
Poly(ADP-ribose) polymerase 1 (PARP1) is an enzyme involved in DNA repair, chromatin organization and transcription. During transcription initiation, PARP1 interacts with gene promoters where it binds to nucleosomes, replaces linker histone H1 and pa
Abstract P-24: Microscopic Analyses of Liquid-Liquid Phase Separation Induced by Linker Histone H1.0
Autor:
Daria Koshkina, Vasily M. Studitsky, N. S. Gerasimova, N. V. Maluchenko, Olga Geraskina, Alexey V. Feofanov
Publikováno v:
International Journal of Biomedicine, Vol 11, Iss Suppl_1, Pp 21-22 (2021)
Background: Liquid-liquid phase separation (LLPS) that leads to the formation of temporary functional domains in cells plays an important role in the processes of chromatin condensation and gene regulation. Earlier, it was demonstrated that histone H
Autor:
Tatyana A. Kurgina, N. S. Gerasimova, Mikhail A. Kutuzov, N. V. Maluchenko, Vasily M. Studitsky, Alexandra Lys, Olga I. Lavrik, Sergey Pushkarev, Alexey V. Feofanov, Vytas K. Švedas, D. K. Nilov
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 6, p 2159 (2020)
International Journal of Molecular Sciences; Volume 21; Issue 6; Pages: 2159
International Journal of Molecular Sciences, Vol 21, Iss 6, p 2159 (2020)
International Journal of Molecular Sciences; Volume 21; Issue 6; Pages: 2159
7-Methylguanine (7-MG), a natural compound that inhibits DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP-1), can be considered as a potential anticancer drug candidate. Here we describe a study of 7-MG inhibition mechanism using molecular dynam
Publikováno v:
Moscow University Biological Sciences Bulletin. 73:142-145
A procedure was developed for the preparation of a stalled elongation complex of Escherichia coli RNA polymerase with the nucleosome for investigation by cryo-electron microscopy. We purified the complex from the excess of free RNA polymerase and unp
Publikováno v:
Moscow University Biological Sciences Bulletin. 73:88-91
Nhp6A is a small nonhistone chromosomal yeast protein that binds DNA nonspecifically. This protein is present at many promoters and transcribed regions of the genome and is involved in regulation of transcription. Recently, Nhp6A was shown to partici
Autor:
N. S. Gerasimova, A. L. Kozlova, F. K. Hsieh, Vasily M. Studitsky, E. Yu. Kotova, Tim Formosa
Publikováno v:
Moscow University Biological Sciences Bulletin. 72:218-221
Nhp6 is a small yeast protein that binds DNA nonspecifically. It has been shown that Nhp6 is a component of several protein complexes (including the FACT complex) and is present on many yeast promoters and transcribed regions of genes in vivo. It als
Publikováno v:
International Journal of Biomedicine, Vol 11, Iss Suppl_1, Pp 21-21 (2021)
Background: Nucleosomes are the barriers to transcript elongation by RNA polymerase 2 (Pol 2) in vitro and in vivo. Formation and overcoming the barrier are important for transcription regulation. N-terminal tails of core histones do not affect the i