Zobrazeno 1 - 10
of 118
pro vyhledávání: '"N. Reynard"'
Autor:
H. W. Lewis, J. M. Castillo Sanchez, J. Graham, A. Saulter, J. Bornemann, A. Arnold, J. Fallmann, C. Harris, D. Pearson, S. Ramsdale, A. Martínez-de la Torre, L. Bricheno, E. Blyth, V. A. Bell, H. Davies, T. R. Marthews, C. O'Neill, H. Rumbold, E. O'Dea, A. Brereton, K. Guihou, A. Hines, M. Butenschon, S. J. Dadson, T. Palmer, J. Holt, N. Reynard, M. Best, J. Edwards, J. Siddorn
Publikováno v:
Geoscientific Model Development, Vol 11, Pp 1-42 (2018)
It is hypothesized that more accurate prediction and warning of natural hazards, such as of the impacts of severe weather mediated through various components of the environment, require a more integrated Earth System approach to forecasting. This
Externí odkaz:
https://doaj.org/article/46a9495747f4482bb257033c41e881f1
Publikováno v:
Epigenetics, Vol 15, Iss 6-7, Pp 594-603 (2020)
DNA methylation of CpG sites is commonly measured using Illumina Infinium BeadChip platforms. The Infinium MethylationEPIC array has replaced the Infinium Methylation450K array. The two arrays use the same technology, with the EPIC array assaying alm
Externí odkaz:
https://doaj.org/article/df1f7d28e78143c3a7cc6a6f2d4c6408
Autor:
Richard Howey, Alexander D Clark, Najib Naamane, Louise N Reynard, Arthur G Pratt, Heather J Cordell
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009811 (2021)
Bayesian networks can be used to identify possible causal relationships between variables based on their conditional dependencies and independencies, which can be particularly useful in complex biological scenarios with many measured variables. Here
Externí odkaz:
https://doaj.org/article/0f1187fea9e34709af36a64f09f121e9
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-9 (2019)
Abstract Background Osteoarthritis (OA) is a common disease of older individuals that impacts detrimentally on the quality and the length of life. It is characterised by the painful loss of articular cartilage and is polygenic and multifactorial. Gen
Externí odkaz:
https://doaj.org/article/ffe635fcb70a49d9ad8410ba05cde729
Autor:
Saad Aldalaqan, Caroline Dalgliesh, Sara Luzzi, Chileleko Siachisumo, Louise N Reynard, Ingrid Ehrmann, David J. Elliott
Publikováno v:
Cell Cycle. 21:219-227
High levels of transcription and alternative splicing are recognized hallmarks of gene expression in the testis and largely driven by cells in meiosis. Because of this, the male meiosis stage of the cell cycle is often viewed as having a relatively p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c4dee82e0617b748ac59624b5976d0
https://doi.org/10.1080/15384101.2021.2015672
https://doi.org/10.1080/15384101.2021.2015672
Autor:
Madhushika Ratnayake, Maria Tselepi, Robert Bloxham, Frank Plöger, Louise N Reynard, John Loughlin
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176523 (2017)
Osteoarthritis (OA) is a common joint disease characterised by the focal loss of the protective cartilage layer at the ends of the bones. It is painful, disabling, multifactorial and polygenic. The growth differentiation factor 5 gene GDF5 was one of
Externí odkaz:
https://doaj.org/article/d79d26bc93634509b282c10bbb86e9cc
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159024 (2016)
The single nucleotide polymorphism (SNP) rs835487 is associated with hip osteoarthritis (OA) at the genome-wide significance level and is located within CHST11, which codes for carbohydrate sulfotransferase 11. This enzyme post-translationally modifi
Externí odkaz:
https://doaj.org/article/481312e702cb440dac5f62a3b298f550
Autor:
Louise N. Reynard, Alexander D. Clark, Arthur G. Pratt, Richard Howey, Najib Naamane, Heather J. Cordell
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 9, p e1009811 (2021)
PLoS Genetics, Vol 17, Iss 9, p e1009811 (2021)
Bayesian networks can be used to identify possible causal relationships between variables based on their conditional dependencies and independencies, which can be particularly useful in complex biological scenarios with many measured variables. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57a76d392716744d0c1dfe503daf6206
http://europepmc.org/articles/PMC8504979
http://europepmc.org/articles/PMC8504979
Autor:
Arthur G. Pratt, Louise N. Reynard, Ellis Niemantsverdriet, Ben Hargreaves, Nisha Nair, Kieran Murray, Najib Naamane, Anne Barton, Alexander D. Clark, Steve Eyre, Nishanthi Thalayasingam, Annette H M van der Helm-van Mil
Publikováno v:
Rheumatology. 60
Background/Aims Early diagnosis and intervention improves outcomes of immune mediated rheumatic and musculoskeletal diseases (RMDs) but may be hampered by diagnostic uncertainty. The extent to which rationally selected molecular parameters add value
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::daf21de0750ff5996b7c1c658d80e4eb
https://doi.org/10.1093/rheumatology/keab246.007
https://doi.org/10.1093/rheumatology/keab246.007
Publikováno v:
PLoS Genetics, Vol 9, Iss 6, p e1003557 (2013)
rs143383 is a C to T transition SNP located in the 5'untranslated region (5'UTR) of the growth differentiation factor 5 gene GDF5. The T allele of the SNP is associated with increased risk of osteoarthritis (OA) in Europeans and in Asians. This susce
Externí odkaz:
https://doaj.org/article/58b8e7f13aab4c6a809551ebf33ed8a2