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Akademický článek

Quantification of circulating TCR-engineered T cells targeting a human endogenous retrovirus post-adoptive transfer using nanoplate digital PCR

Autor: Stefan Barisic, Elena Cherkasova, Rosa Nadal, Xin Tian, Long Chen, Angelina Parrizzi, Robert N. Reger, Gina M. Scurti, Michael I. Nishimura, Richard W. Childs

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 3, Pp 101324- (2024)

In vivo expansion of genetically modified T cells in cancer patients following adoptive transfer has been linked to both anti-tumor activity and T cell-mediated toxicities. The development of digital PCR has improved the accuracy in quantifying the i

Externí odkaz: https://doaj.org/article/5b592d3693804319b37fe4a8cf5d58bf

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Akademický článek

Systematic improvements in lentiviral transduction of primary human natural killer cells undergoing ex vivo expansion

Autor: David S.J. Allan, Mala Chakraborty, Giacomo C. Waller, Michael J. Hochman, Akkapon Poolcharoen, Robert N. Reger, Richard W. Childs

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 559-571 (2021)

Transduction of primary human natural killer (NK) cells with lentiviral vectors has historically been challenging. We sought to evaluate multiple parameters to optimize lentiviral transduction of human peripheral blood NK cells being expanded to larg

Externí odkaz: https://doaj.org/article/2d3b060a8c104e1cbf96970d0c3841f6

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