Zobrazeno 1 - 10
of 19
pro vyhledávání: '"N. R. Movva"'
Autor:
M. C. Cruz, N. R. Movva, Joseph Heitman, Ping Wang, Gerhard Zenke, V. F. J. Quesniaux, M Del Poeta, Roland Wenger, John R. Perfect, Maria E. Cardenas
Publikováno v:
Antimicrobial Agents and Chemotherapy. 44:143-149
Cyclosporine (CsA) is an immunosuppressive and antimicrobial drug which, in complex with cyclophilin A, inhibits the protein phosphatase calcineurin. We recently found that Cryptococcus neoformans growth is resistant to CsA at 24°C but sensitive at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa84227c9c903e8277c76416a65144ad
https://doi.org/10.1128/aac.44.1.143-149.2000
https://doi.org/10.1128/aac.44.1.143-149.2000
Autor:
Antonius Koller, Joseph Heitman, Jeannette Kunz, Alexander Schmidt, Michael N. Hall, Ruben Henriquez, N R Movva
Publikováno v:
Molecular and Cellular Biology. 13:5010-5019
The immunosuppressants cyclosporin A, FK506, and rapamycin inhibit growth of unicellular eukaryotic microorganisms and also block activation of T lymphocytes from multicellular eukaryotes. In vitro, these compounds bind and inhibit two different type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48c3227f30f74eddd3f00d5f58db56e4
https://doi.org/10.1128/mcb.13.8.5010
https://doi.org/10.1128/mcb.13.8.5010
Publikováno v:
Proceedings of the National Academy of Sciences. 88:1948-1952
FK 506 and cyclosporin A are potent immunosuppressive compounds that inhibit T-cell activation by interfering with signal transduction. In vitro, FK 506 binds and inhibits the activity of FK 506-binding protein (FKBP), a peptidylprolyl rotamase (cis-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b23e0524686b9d05fe968408984026c
https://doi.org/10.1073/pnas.88.5.1948
https://doi.org/10.1073/pnas.88.5.1948
Autor:
Dominique Semon, Meyer C, Paul T. Wingfield, C G Miller, N. R. Movva, J L Miller, Eric Kawashima
Publikováno v:
Molecular and General Genetics MGG. 223:345-348
The pepM gene coding for a methionine-specific aminopeptidase was cloned from Salmonella typhimurium and its nucleotide sequence determined. The gene encoded a 264 amino acid protein that was homologous to a similar protein from Escherichia coli. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb94259d1b6a0b9abf55176b0d4fc16
https://doi.org/10.1007/bf00265075
https://doi.org/10.1007/bf00265075
The immunophilin-immunosuppressant complexes cyclophilin-cyclosporin A (CsA) and FKBP12-FK506 inhibit the phosphatase calcineurin to block T-cell activation. Although cyclophilin A, FKBP12, and calcineurin are highly conserved from yeast to man, none
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d009769d6e4a65e770f07ccf2e40ecf
https://europepmc.org/articles/PMC43997/
https://europepmc.org/articles/PMC43997/
Publikováno v:
The New biologist. 4(5)
The immunosuppressants cyclosporin A (CsA), FK506, and rapamycin block T-cell activation by interfering with signal transduction. The institution of CsA therapy for prophylaxis against graft rejection revolutionized human organ transplants, and clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f0d0f35e3c076d3a06264716c899d59a
https://pubmed.ncbi.nlm.nih.gov/1515410
https://pubmed.ncbi.nlm.nih.gov/1515410
Publikováno v:
Science (New York, N.Y.). 253(5022)
FK506 and rapamycin are related immunosuppressive compounds that block helper T cell activation by interfering with signal transduction. In vitro, both drugs bind and inhibit the FK506-binding protein (FKBP) proline rotamase. Saccharomyces cerevisiae
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af903ab3c88c0f618c4b67d05ee9e4a
https://pubmed.ncbi.nlm.nih.gov/1715094
https://pubmed.ncbi.nlm.nih.gov/1715094
Publikováno v:
The Journal of biological chemistry. 266(16)
Recombinant human interleukin-3 (rhuIL-3) variants were generated by site-directed mutagenesis and expression in Escherichia coli. Amino acid deletions and substitutions were made in the previously identified epitopes of two huIL-3-specific neutraliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b749bc7bf612fae0e705e6c4c083d27
https://pubmed.ncbi.nlm.nih.gov/2037601
https://pubmed.ncbi.nlm.nih.gov/2037601
Publikováno v:
Journal of Bacteriology. 133:81-84
The gene dosage effects of the structural gene (lpp) for the lipoprotein of the Escherichia coli outer membrane were examined. A novel F-prime factor containing the lpp gene was constructed. The amount of the free-form lipoprotein in the merodiploid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::648537bfa5bc95a3b653cf27f6412b2b
https://doi.org/10.1128/jb.133.1.81-84.1978
https://doi.org/10.1128/jb.133.1.81-84.1978
Publikováno v:
Proceedings of the National Academy of Sciences. 83:4219-4222
Pro-OmpA is processed to OmpA by isolated inverted plasma membrane vesicles from Escherichia coli. In the presence of ATP and a membrane potential, 58% (+/- 13%) of the OmpA is sequestered in the vesicles. We sought to determine which of these two me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fee88c4112529331109ad5bd4711344
https://doi.org/10.1073/pnas.83.12.4219
https://doi.org/10.1073/pnas.83.12.4219