Zobrazeno 1 - 10 of 99 pro vyhledávání: '"N. R. Farnsworth"'
4
Trials and Tribulations of Planning and Conducting a Phase 2 Clinical Trial with Black Cohosh and Red Clover
Autor: N. R. Farnsworth
Publikováno v: Planta Medica. 75
A Phase 2 clinical trial with Black Cohosh and Red Clover was conceived in 2000 within our UIC/NIH Center for Botanical Dietary Supplement Research on Women's Health. Prior to implementing the trial, a Phase 1 study was required and approval from FDA
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ffaf03b4c4e66d1a9e100f5bd9e9786c
https://doi.org/10.1055/s-2009-1216394
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6
Modulation of the multidrug-resistance phenotype by new tropane alkaloid aromatic esters from Erythroxylum pervillei
Autor: G L, Silva, B, Cui, D, Chávez, M, You, H B, Chai, P, Rasoanaivo, S M, Lynn, M J, O'Neill, J A, Lewis, J M, Besterman, A, Monks, N R, Farnsworth, G A, Cordell, J M, Pezzuto, A D, Kinghorn
Publikováno v: Journal of natural products. 64(12)
Nine tropane alkaloid aromatic esters (1-9) were isolated from the roots of Erythroxylum pervillei by following their potential to reverse multidrug-resistance with vinblastine-resistant oral epidermoid carcinoma (KB-V1) cells. All isolates, includin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0409e6128e6433c81864780c1f516f11
https://pubmed.ncbi.nlm.nih.gov/11754602
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7
Plant antitumor agents. 31. The calycopterones, a new class of biflavonoids with novel cytotoxicity in a diverse panel of human tumor cell lines
Autor: M E, Wall, M C, Wani, F, Fullas, J B, Oswald, D M, Brown, T, Santisuk, V, Reutrakul, A T, McPhail, N R, Farnsworth, J M, Pezzuto
Publikováno v: Journal of medicinal chemistry. 37(10)
Three new biflavonoids to which we have accorded the trivial names calycopterone (1), isocalycopterone (2), and 4-demethylcalycopterone (3) and the known flavone 4',5-dihydroxy-3,3',6,7-tetramethoxyflavone (4) were isolated as cytotoxic constituents
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fd254a6e9527b96995f1ccbe9cd5d415
https://pubmed.ncbi.nlm.nih.gov/8182705
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8
Ethnopharmacology and drug development
Autor: N R, Farnsworth
Publikováno v: Ciba Foundation symposium. 185
The value of ethanomedical information in drug development is based on several factors: accuracy in recording or observing the medical use of the ethnomedical preparation, whether or not the ethnomedical use can be corroborated under scientific condi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::799de47b5c7f611bc4f85812886b1b85
https://pubmed.ncbi.nlm.nih.gov/7736861
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9
Sesquiterpene lactones and other constituents from a cytotoxic extract of Michelia floribunda
Autor: I O, Mondranondra, C T, Che, A M, Rimando, S, Vajrodaya, H H, Fong, N R, Farnsworth
Publikováno v: Pharmaceutical research. 7(12)
The pentane and CHCl3 fractions of a crude extract of Michelia floribunda exhibited cytotoxic activity when tested in KB and P388 tumor cell cultures. Repeated chromatography led to the isolation of three cytotoxic sesquiterpene lactones (costunolide
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b66dd9acba2f0d623647c613aa943514
https://pubmed.ncbi.nlm.nih.gov/2095565
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10
The role of ethnopharmacology in drug development
Autor: N R, Farnsworth
Publikováno v: Ciba Foundation symposium. 154
There are 119 drugs of known structure that are still extracted from higher plants and used globally in allopathic medicine. About 74% of these were discovered by chemists who were attempting to identify the chemical substances in the plants that wer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::30d37b5e68c629a52b3b4c4d5f2d5775
https://pubmed.ncbi.nlm.nih.gov/2086037
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