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The Complete Pathway for Catalytic Activation of the Mitogen-activated Protein Kinase, ERK2

Autor: John Lew, Claudine N. Prowse, Micheal S. Deal

Publikováno v: Journal of Biological Chemistry. 276:40817-40823

The mitogen-activated protein (MAP) kinase ERK2 is an essential signal transduction molecule that mediates extracellular signaling by all polypeptide growth factors. Full activation of ERK2 requires phosphorylation at both a threonine residue (Thr(18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02cc3d9535fd8722e1449ed0087cd888
https://doi.org/10.1074/jbc.m105860200

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Mechanism of Activation of ERK2 by Dual Phosphorylation

Autor: Claudine N. Prowse, John Lew

Publikováno v: Journal of Biological Chemistry. 276:99-103

The mitogen-activated protein (MAP) kinases are characterized by their requirement for dual phosphorylation at a conserved threonine and tyrosine residue for catalytic activation. The structural consequences of dual-phosphorylation in the MAP kinase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c432efb27263d61806e5859664cc7c7e
https://doi.org/10.1074/jbc.m008137200

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Catalytic Reaction Pathway for the Mitogen-Activated Protein Kinase ERK2

Autor: Melanie H. Cobb, Claudine N. Prowse, Jonathan C. Hagopian, John Lew, Natalie G. Ahn

Publikováno v: Biochemistry. 39:6258-6266

The structural, functional, and regulatory properties of the mitogen-activated protein kinases (MAP kinases) have long attracted considerable attention owing to the critical role that these enzymes play in signal transduction. While several MAP kinas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401d7ba21dd34dcf48fbb3d145ad7506
https://doi.org/10.1021/bi000277b

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Inhibition of mouse acetylcholinesterase by fasciculin: Crystal structure of the complex and mutagenesis of fasciculin

Autor: Yves Bourne, Palmer Taylor, Pascale Marchot, Pierre E. Bougis, Claudine N. Prowse

Publikováno v: Toxicon
Toxicon, Elsevier, 1998, 36 (11), pp.1613-1622. ⟨10.1016/s0041-0101(98)00154-8⟩
Toxicon, 1998, 36 (11), pp.1613-1622. ⟨10.1016/s0041-0101(98)00154-8⟩

International audience; Fasciculins are members of the superfamily of three-fingered peptidic toxins from Elapidae venoms. They selectively inhibit mammalian and electric fish acetylcholinesterases (AChE) with Ki values in the pico- to nanomolar rang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5fd57fd4b331932cdb9739e531edd84
https://doi.org/10.1016/s0041-0101(98)00154-8

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Expression and Activity of Mutants of Fasciculin, a Peptidic Acetylcholinesterase Inhibitor from Mamba Venom

Autor: Claudine N. Prowse, Elizabeth J. Ackermann, Pierre E. Bougis, Shelley Camp, Zoran Radić, Joan R. Kanter, Palmer Taylor, Pascale Marchot

Publikováno v: Journal of Biological Chemistry. 272:3502-3510

Fasciculin, a selective peptidic inhibitor of acetylcholinesterase, is a member of the three-fingered peptide toxin superfamily isolated from snake venoms. The availability of a crystal structure of a fasciculin 2 (Fas2)-acetylcholinesterase complex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff742d31463e30610dc975934573f8f3
https://doi.org/10.1074/jbc.272.6.3502

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The Synthesis Telescope at the Dominion Radio Astrophysical Observatory

Autor: J. F. Vaneldik, Peter E. Dewdney, N. Prowse, T. A. Burgess, R. S. Roger, W. Wyslouzil, D. R. Karpa, D. Routledge, A. D. Gray, L. A. Higgs, T. L. Landecker, A. P. Hoffmann, A. G. Willis, J. D. Lacey, C. R. Purton, G. J. Hovey

We describe an aperture synthesis radio telescope optimized for studies of the Galactic interstellar medium (ISM), providing the ability to image extended structures with high angular resolution over wide fields. The telescope produces images of atom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf2ec189f6097261cb3b15fd46ccf784
http://arxiv.org/abs/astro-ph/0006415

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Fasciculin Inhibition of Mouse Acetylcholinesterase

Autor: Jonathan Eads, Yves Bourne, Joan R. Kanter, Palmer Taylor, Pascale Marchot, Claudine N. Prowse, Pierre E. Bougis

Publikováno v: Structure and Function of Cholinesterases and Related Proteins ISBN: 9781489915429

Fasciculins are 7 kDa proteins that contain four disulfide bridges and are isolated from mamba venoms. They are members of the superfamily of three-fingered Elapidae snake toxins that include the selective nicotinic acetylcholine receptor blockers, �

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e599f83e54ba9d45151bfa4d57fe7f4
https://doi.org/10.1007/978-1-4899-1540-5_94

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Akademický článek

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