Zobrazeno 1 - 10
of 49
pro vyhledávání: '"N. Prakash Prabhu"'
Autor:
Sonika Kar, T.S. Sreevidya, Rucha Y. Hebalkar, Pratibha Kushwaha, Balasubramanian Senthilkumaran, N. Prakash Prabhu
Publikováno v:
Re:GEN Open, Vol 3, Iss 1, Pp 21-33 (2023)
Background: Cytochrome P450 11?-hydroxylase (H11b) converts testosterone (T) into 11-hydroxytestosterone. In Clarias batrachus (catfish), H11b occurs in regular form and has three variants as well. The variant forms contain the complete steroid bindi
Externí odkaz:
https://doaj.org/article/1ce6b5dcf1be4a6688e133f1906acd3e
Publikováno v:
BMC Research Notes, Vol 11, Iss 1, Pp 1-7 (2018)
Abstract Objective Present in silico study was carried out to explore the mode of inhibition of Leishmania donovani dihydrofolate reductase-thymidylate synthase (Ld DHFR-TS) enzyme by Withaferin-A, a withanolide isolated from Withania somnifera. With
Externí odkaz:
https://doaj.org/article/f0b6479295e64e3dbc2094a347216d67
Autor:
Archi, Saurabh, N Prakash, Prabhu
Publikováno v:
International Journal of Biological Macromolecules. 223:1024-1041
Fibril formation of α-synuclein is linked with Parkinson's disease. The intrinsically disordered nature of α-syn provides extensive conformational plasticity and becomes difficult to characterize its transition pathway from native monomeric to dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed00d25b3aee88b603e18d93fb3e3341
https://doi.org/10.1016/j.ijbiomac.2022.11.079
https://doi.org/10.1016/j.ijbiomac.2022.11.079
Autor:
Dipti Singh, Smita Patri, Veeda Narahari, Rameswara R. Segireddy, Sandeep Dey, Archi Saurabh, Macha Vijay, N. Prakash Prabhu, Anand Srivastava, Surendra Kumar Kolli, Kota Arun Kumar
Publikováno v:
Molecular Microbiology. 117:1324-1339
Plasmodium sporozoites are extracellular forms introduced during mosquito bite that selectively invade mammalian hepatocytes. Sporozoites are delimited by a cell membrane that is linked to the underlying acto-myosin molecular motor. While membrane pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074b3798fc9316eb2fbf8b67b6eeca2e
https://doi.org/10.1111/mmi.14894
https://doi.org/10.1111/mmi.14894
Autor:
Pratibha Kushwaha, N. Prakash Prabhu
Publikováno v:
New Journal of Chemistry. 46:11082-11094
Imidazolium ionic liquids with longer alkyl side chains show a larger destabilization effect on lysozyme. Increased hydrophobicity of the IL increases its binding affinity and inhibits the fibril formation of lysozyme.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74507907293d008cc2b10d38d46f5638
https://doi.org/10.1039/d2nj00559j
https://doi.org/10.1039/d2nj00559j
Polyols, increasing global stability of cytochrome c, destabilize the thermal unfolding intermediate
Autor:
K. Tejaswi Naidu, N. Prakash Prabhu
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 40:11216-11228
Studies on the intermediate states of proteins provide essential information on folding pathway and energy landscape of proteins. Osmolytes, known to alter the stability of proteins, might also aff...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7835207117c100309a461737fa0a18fb
https://doi.org/10.1080/07391102.2021.1956593
https://doi.org/10.1080/07391102.2021.1956593
Publikováno v:
The Journal of Physical Chemistry B. 124:10077-10088
Osmolytes are known to stabilize proteins under stress conditions. Thermal denaturation studies on globular proteins (β-lactoglobulin, cytochrome c, myoglobin, α-chymotrypsin) in the presence of ethylene glycol (EG), a polyol class of osmolyte, dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a873c235ddc391a58635b7cb76b67f9
https://doi.org/10.1021/acs.jpcb.0c06247
https://doi.org/10.1021/acs.jpcb.0c06247
Autor:
K. Tejaswi Naidu, N. Prakash Prabhu
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 40:820-832
Osmolytes are known to stabilize proteins against denaturing conditions. Ethylene glycol (EG), however, shows a distinctive effect on α-lactalbumin (α-LA) that it stabilizes the protein against cold-induced denaturation, whereas it destabilizes dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ea7bd770d1f696dc569348ce32c608
https://doi.org/10.1080/07391102.2020.1819422
https://doi.org/10.1080/07391102.2020.1819422
Autor:
Bramhini Anumalla, N. Prakash Prabhu
Publikováno v:
ChemistrySelect. 4:13797-13801
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8a03517afc3e57b4871581837897e02
https://doi.org/10.1002/slct.201903122
https://doi.org/10.1002/slct.201903122
Autor:
Bramhini Anumalla, N. Prakash Prabhu
Publikováno v:
Applied Biochemistry and Biotechnology. 189:541-555
Studies on osmolyte-induced effects on proteins help in enhancing protein stability under stressed conditions for various applications. Using mixtures of osmolytes could indeed widen their applications. The combinatorial effects of osmolytes with met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45b7d5575a0d8d60badeb1756ea3812
https://doi.org/10.1007/s12010-019-03026-w
https://doi.org/10.1007/s12010-019-03026-w