Výsledky vyhledávání - "N. Podkuychenko"

Chemical Inducers of Obesity-Associated Metabolic Stress Activate Inflammation and Reduce Insulin Sensitivity in 3T3-L1 Adipocytes

Autor: N. Podkuychenko, S. Michurina, Ye. V. Parfyonova, I. S. Stafeev, Mikhail Menshikov, Alexander V. Vorotnikov

Publikováno v: Biochemistry (Moscow). 84:553-561

Obesity is accompanied by dyslipidemia, hypoxia, endoplasmic reticulum (ER) stress, and inflammation, representing the major risk factor for the development of insulin resistance (IR) and type 2 diabetes. We modeled these conditions in cultured 3T3-L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3777de267431fed50d058b5691a51e
https://doi.org/10.1134/s0006297919050092

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Low proliferative potential of adipose-derived stromal cells associates with hypertrophy and inflammation in subcutaneous and omental adipose tissue of patients with type 2 diabetes mellitus

Autor: S. Michurina, E. I. Ratner, Ekaterina A. Shestakova, N. Podkuychenko, Ye. V. Parfyonova, I. S. Stafeev, A. Panevina, Yuriy Ivanovich Yashkov, Marina Vladimirovna Shestakova, Mikhail Menshikov, V. Fedenko, Igor A. Sklyanik, Alexander V. Vorotnikov, Kamil Yahyaev

Publikováno v: Journal of Diabetes and its Complications. 33:148-159

Background Obesity and type 2 diabetes mellitus (T2DM) are among the most important morbidity factors. In this study we tested the hypothesis that low proliferative potential of adipose derived stromal cells (ADSC) associates with reduced formation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8878e2e0e542b99fb6a5cda59f9c081
https://doi.org/10.1016/j.jdiacomp.2018.10.011

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440-P: Dual Long-Term Effects of Free Fatty Acid on Human Endothelial Barrier In Vitro Are Mediated by NO, Mitochondrial ROS, and Dicarbonyl Stress

Autor: N. Podkuychenko, Marina Vladimirovna Shestakova, Asker Y. Khapchaev, Alexander V. Vorotnikov, Maxim Skulachev, Vladimir P. Shirinsky, Tatiana Vlasik, Vadim Z. Lankin, I. S. Stafeev, Mikhail V. Samsonov

Publikováno v: Diabetes. 70

In diabetes-associated hyperlipidemia, free fatty acids (FFAs) are thought to induce insulin resistance and endothelial dysfunction leading to vascular injury and cardiovascular T2DM complications. However, evidence is scarce regarding the effects of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8aea804be633fcddb15730a4c8621d9c
https://doi.org/10.2337/db21-440-p

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1147-P: Pseudo Insulin Resistance: Palmitate Inactivates Insulin Signaling but Stimulates Basal Glucose Uptake in 3T3-L1 Adipocytes

Autor: N. Podkuychenko, Asker Y. Khapchaev, Alexander V. Vorotnikov, I. S. Stafeev, Vladimir P. Shirinsky, S. Michurina

Publikováno v: Diabetes. 70

Increased levels of circulating free fatty acids (FFA) is the major risk factor for type 2 diabetes in obesity. While the long-term effects of increased FFA on adipose tissue likely involve latent inflammation, the short-term effects on insulin-sensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66ded2252a4331dcf58a8ebe17848527
https://doi.org/10.2337/db21-1147-p

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The synthetic glucagon-like peptide-1 receptor agonist liraglutide affects the kinetics of pro-inflammatory kinases and improves insulin sensitivity of 3T3-L1 adipocytes

Autor: Y.E. Parfyonova, I. S. Stafeev, E. Sorkina, E. Mamontova, Mikhail Menshikov, N. Podkuychenko, S. Michurina, Marina Vladimirovna Shestakova

Publikováno v: European Heart Journal. 41

Background Obesity is the main risk factor of latent inflammation, which leads to insulin resistance (IR) which can transform to type 2 diabetes mellitus (T2DM). Today several groups of drugs are used to correct T2DM and its complications. The most p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::549d7b00e53d13d8c7922835ad9ba32a
https://doi.org/10.1093/ehjci/ehaa946.3038

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Interleukin-4 Restores Insulin Sensitivity in Lipid-Induced Insulin-Resistant Adipocytes

Autor: Alexander V. Vorotnikov, Ye. V. Parfyonova, S. Michurina, N. Podkuychenko, M. Yu. Men’shikov, I. S. Stafeev

Publikováno v: Biochemistry (Moscow). 83:498-506

Obesity and latent inflammation in adipose tissue significantly contribute to the development of insulin resistance (IR) and type 2 diabetes. Here we studied whether the antiinflammatory interleukin-4 (IL-4) can restore insulin sensitivity in culture

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc869fee0b5cdf163dcb9c6b55c85630
https://doi.org/10.1134/s0006297918050036

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P4406New hypothesis of the insulin resistance development: role of adipose-derived stem cell proliferation and adipogenesis

Autor: A. Panevina, S. Michurina, Marina Vladimirovna Shestakova, N. Podkuychenko, Kamil Yahyaev, Ekaterina A. Shestakova, I. S. Stafeev, E. I. Ratner, Yuriy Ivanovich Yashkov, Y E Parfyonova, Mikhail Menshikov, Igor A. Sklyanik, Alexander V. Vorotnikov

Publikováno v: European Heart Journal. 40

Background Obesity, remaining a topical issue of modern medicine, leads to development of latent inflammation and insulin resistance in adipose tissue with subsequent development of type 2 diabetes mellitus (T2DM). Among patients with obesity, patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa64653239a343f703572ebd462cb3c7
https://doi.org/10.1093/eurheartj/ehz745.0811

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Decreased UCP-1 expression in beige adipocytes from adipose-derived stem cells of type 2 diabetes patients associates with mitochondrial ROS accumulation during obesity

Autor: S. Michurina, Anatoliy Yurasov, Mikhail Menshikov, Igor A. Sklyanik, E. I. Ratner, N. Podkuychenko, Yelena V. Parfyonova, Marina Vladimirovna Shestakova, Ekaterina A. Shestakova, Kamil Yahyaev, I. S. Stafeev

Publikováno v: Diabetes Research and Clinical Practice. 169:108410

Objective Adipose derived stem cells (ADSC) are defective in metabolic disorders in various functionalities and properties including differentiation, multipotent state, metabolism and immunomodulation. However, the role of ADSC beiging potential in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc45ca669e4f2f438fbb4972e0d95b49
https://doi.org/10.1016/j.diabres.2020.108410

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