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Akademický článek

Bioanalytical Assay Development and Validation for the Pharmacokinetic Study of GMC1, a Novel FKBP52 Co-chaperone Inhibitor for Castration Resistant Prostate Cancer

Autor: Oscar Ekpenyong, Candace Cooper, Jing Ma, Naihsuan C. Guy, Ashley N. Payan, Fuqiang Ban, Artem Cherkasov, Marc B. Cox, Dong Liang, Huan Xie

Publikováno v: Pharmaceuticals, Vol 13, Iss 11, p 386 (2020)

Background: GMC1 (2-(1H-benzimidazol-2-ylsulfanyl)-N-[(Z)-(4-methoxyphenyl) methylideneamino] acetamide) effectively inhibits androgen receptor function by binding directly to FKBP52. This is a novel mechanism for the treatment of castration resistan

Externí odkaz: https://doaj.org/article/2618ea822bf5400b9641607a3a58a63b

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PO-1769 Prostate cancer radiogenomics machine learning classification for predicting disease progression

Autor: R. Murphy, N. Payan, S. Osman, K. Prise, A. Hounsell, J. O'Sullivan, C. McGarry, S. Jain

Publikováno v: Radiotherapy and Oncology. 170:S1572-S1574

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9a0d5040985df1a5e092fdc8822fdf0
https://doi.org/10.1016/s0167-8140(22)03733-1

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PO-1758 Performance assessment of radiogenomics machine learning models for stratifying prostate cancer risk

Autor: N. Payan, R.G. Murphy, S. Jain, A.R. Hounsell, S. Osman, J.M. O'Sullivan, K.M. Prise, C.K. McGarry

Publikováno v: Radiotherapy and Oncology. 170:S1562-S1563

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4e9bc8c7fcafe7166f8b8d037c6a866
https://doi.org/10.1016/s0167-8140(22)03722-7

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Bioanalytical Assay Development and Validation for the Pharmacokinetic Study of GMC1, a Novel FKBP52 Co-chaperone Inhibitor for Castration Resistant Prostate Cancer

Autor: Artem Cherkasov, Ashley N Payan, Fuqiang Ban, Naihsuan Guy, Huan Xie, Candace Cooper, Dong Liang, Oscar Ekpenyong, Jing Ma, Marc B. Cox

Publikováno v: Pharmaceuticals
Volume 13
Issue 11
Pharmaceuticals, Vol 13, Iss 386, p 386 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4b65bedf7fd4fb591e69fb86b8014e4
http://europepmc.org/articles/PMC7698315

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Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone

Autor: Nina R. Ortiz, Laura J. Blair, Marc B. Cox, Jeffrey C. Sivils, David S. Culbertson, Jane Dyson, Ashley N Payan, Dan Finley, Jazzmin Jovonna Owens, Jason E. Gestwicki, Szu Yu Kuo, William E. Balch, Jaideep Chaudhary, Jay Singh, Darren M. Hutt, Chad A. Dickey, Naihsuan Guy, Bradley D. Tait, Shravan Kumar Komaragiri

Publikováno v: Cell chemical biology, vol 27, iss 3
Cell Chem Biol

Summary Hsp90 plays an important role in health and is a therapeutic target for managing misfolding disease. Compounds that disrupt co-chaperone delivery of clients to Hsp90 target a subset of Hsp90 activities, thereby minimizing the toxicity of pan-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c800b824e420391f461894a73274c69
https://escholarship.org/uc/item/3k55j4vx

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Texture analysis of tumour metabolism and perfusion for newly diagnosed breast cancer using dynamic first-pass 18F-FDG PET/CT

Autor: N, Payan, Presles, Benoît, Vrigneaud, Jean-Marc, Cochet, Alexandre

Publikováno v: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
31st Annual Congress of the European-Association-of-Nuclear-Medicine (EANM)
31st Annual Congress of the European-Association-of-Nuclear-Medicine (EANM), European-Association-of-Nuclear-Medicine (EANM), Oct 2018, Dusseldorf, Germany. Meeting Abstract: OP-669, p.S215-S216

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3e8f94caffec23b7041fcb7a940147ed
https://hal-univ-bourgogne.archives-ouvertes.fr/hal-02001630

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Functional Comparison of Human and Zebra Fish FKBP52 Confirms the Importance of the Proline-Rich Loop for Regulation of Steroid Hormone Receptor Activity

Autor: Yenni A. Garcia, Veronica W Rowlett, Ashley N Payan, Diondra C. Harris, Cheryl Storer Samaniego, Marc B. Cox, Tatsuya Maehigashi, Nina R. Ortiz

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 21, p 5346 (2019)
Volume 20
Issue 21

Previous studies demonstrated that the 52-kDa FK506-binding protein (FKBP52) proline-rich loop is functionally relevant in the regulation of steroid hormone receptor activity. While zebra fish (Danio rerio
Dr) FKBP52 contains all of the analogou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006fe425079153a2fa994f2a005ec84c
https://doi.org/10.3390/ijms20215346

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