Zobrazeno 1 - 10
of 35
pro vyhledávání: '"N. Paul King"'
Autor:
Alan D. Borthwick, Marie Charbaut, Robert J. Young, Máire A. Convery, Ivan Leo Pinto, Andrew M. Mason, Weston Helen Elisabeth, Matthew Campbell, David W. Brown, Anthony J. Pateman, Henry Anderson Kelly, Derek Pollard, Shah Gita Punjabhai, John R. Toomey, N. Paul King, Stefan Senger, Eric Hortense, Ping Zhou, Hawa Diallo, Nigel S. Watson, Wendy R. Irving, Angela Patikis, Cynthia L. Burns-Kurtis, Savvas Kleanthous, Chuen Chan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:28-33
Structure and property based drug design was exploited in the synthesis of sulfonamidopyrrolidin-2-one-based factor Xa (fXa) inhibitors, incorporating basic biaryl P4 groups, producing highly potent inhibitors with significant anticoagulant activitie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03145f782eb525e093f927857c7919cd
https://doi.org/10.1016/j.bmcl.2007.11.019
https://doi.org/10.1016/j.bmcl.2007.11.019
Publikováno v:
Angewandte Chemie International Edition. 44:618-621
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0577310c153d2beaf3fbc18a04af60b9
https://doi.org/10.1002/anie.200462023
https://doi.org/10.1002/anie.200462023
Publikováno v:
Synthesis. :3279-3282
Furan-2-ylmethyl, thien-2-ylmethyl and pyrrol-2-ylmethyl tosylacetates undergo facile decarboxylative Claisen rearrangement upon exposure to N,O-bis(trimethylsilyl)acetamide-potassium acetate to yield the corresponding 2,3-disubstituted heteroaromati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8b0766672d84058ea5d26aa795bb13
https://doi.org/10.1055/s-2005-918448
https://doi.org/10.1055/s-2005-918448
Autor:
N. Paul King, Yun He, Dionisios Vourloumis, Frank Roschangar, Tianhu Li, Kyriacos C. Nicolaou
Publikováno v:
Angewandte Chemie International Edition. 37:84-87
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be2c6bac9f33f27f26867a5e036eecf3
https://doi.org/10.1002/(sici)1521-3773(19980202)37:1/2<84::aid-anie84>3.0.co
https://doi.org/10.1002/(sici)1521-3773(19980202)37:1/2<84::aid-anie84>3.0.co
Autor:
Frank Roschangar, N. Paul King, Tianhu Li, Dionisios Vourloumis, Yun He, Kyriacos C. Nicolaou
Publikováno v:
Angewandte Chemie. 110:89-92
Ringschlus durch Olefinmetathese (siehe unten, a), Abspaltung der Schutzgruppe (b), Stille-Kupplung (c) und die abschliesende Epoxidierung (d) sind die wesentlichen Schritte der ersten Totalsynthese des naturlich vorkommenden Epothilons E 1. Ausgehen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::426c1dd5b8e51665d823dd88f560543e
https://doi.org/10.1002/(sici)1521-3757(19980116)110:1/2<89::aid-ange89>3.0.co
https://doi.org/10.1002/(sici)1521-3757(19980116)110:1/2<89::aid-ange89>3.0.co
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1027-1038
We have identified a new class of catalysts for the asymmetric reduction of prochiral ketones by borane. Key to the architecture of effective catalysts is an N–PO structural unit which may be part of a phosphinamide, phosphonamide or a related stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2eb75a37ee83944aa950c9e6dccc1482
https://doi.org/10.1039/a709174e
https://doi.org/10.1039/a709174e
Autor:
S. Ninkovic, Kyriacos C. Nicolaou, Dionisios Vourloumis, F. Sarabia, N. Paul King, M. Ray V. Finlay, Yun He
Publikováno v:
Chemistry - A European Journal. 3:1971-1986
In order to probe structure-activity relationships in the epothilone area, two series of epothilone B analogues have been designed and synthesized. The first series containing an oxazole moiety in place of a thiazole on the side chain was constructed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32ea56b1bb0fe85af6aad5e0cb5ae2c3
https://doi.org/10.1002/chem.19970031212
https://doi.org/10.1002/chem.19970031212
Autor:
Frank Roschangar, Kyriacos C. Nicolaou, Hans Vallberg, Christopher G. Nicolaou, N. Paul King, Dionisios Vourloumis, Yun He
Publikováno v:
Chemistry - A European Journal. 3:1957-1970
For structure-activity relationship studies, two series of epothilone A (1) analogues have been designed and synthesized, one containing an oxazole moiety instead of the thiazole heterocycle and the other containing a spirocyclopropane moiety in plac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3b0502d0deedc022700412d9baa0638
https://doi.org/10.1002/chem.19970031211
https://doi.org/10.1002/chem.19970031211
Autor:
M. Ray V. Finlay, Hans Vallberg, F. Sarabia, Pareskevi Giannakakou, Pascal Verdier-Pinard, Ernest Hamel, Joaquin Pastor, N. Paul King, Kyriacos C. Nicolaou, Nicolas Winssinger, S. Ninkovic, Dionisios Vourloumis, Frank Roschanger, Tianhu Li, Yun He
Publikováno v:
Angewandte Chemie. 109:2181-2187
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95662762d374a20886b5e4508bc4e297
https://doi.org/10.1002/ange.19971091917
https://doi.org/10.1002/ange.19971091917
Publikováno v:
Tetrahedron: Asymmetry. 5:801-804
A number of new catalysts for the asymmetric reductions of ketones by borane are described. The highest accelerations are achieved by catalysts in which the phosphinamide (R 2 NPO) unit can adopt a planar geometry. This observation has provided an in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee1002f3626fb1e76f806857ac3ed23a
https://doi.org/10.1016/s0957-4166(00)86231-x
https://doi.org/10.1016/s0957-4166(00)86231-x