Výsledky vyhledávání - "N. Pasdeloup"

The new orally active iron chelator ICL670A exhibits a higher antiproliferative effect in human hepatocyte cultures than O-trensox

Autor: Havouis R, François Gaboriau, Pierre Brissot, N. Pasdeloup, Jean-Louis Pierre, Hanspeter Nick, Gérard Lescoat, Karine Chantrel-Groussard

Publikováno v: European Journal of Pharmacology. 541:129-137

By comparing the antiproliferative effect of the iron chelators ICL670A and O-trensox in the human hepatoma cell line HUH7 and human hepatocyte cultures, we have shown that ICL670A decreased cell viability, inhibited DNA replication and induced DNA f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91feded46ad9dc0f9db9fb0d5f91c76
https://doi.org/10.1016/j.ejphar.2006.05.001

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Antiproliferative and apoptotic effects in rat and human hepatoma cell cultures of the orally active iron chelator ICL670 compared to CP20: a possible relationship with polyamine metabolism

Autor: Pierre Brissot, Harry S. Nick, K. Chantrel-Groussard, Gérard Lescoat, François Gaboriau, N. Pasdeloup

Publikováno v: Cell proliferation. 40(5)

Objective: Iron loading has been observed to have a hyperproliferative effect on hepatocytes in vitro and on tumour cells in vivo; removal of this iron being required to induce antitumour activity. Material and Methods: Antiproliferative effects of o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d67a967626bd1df7a6194d7e0110b26
https://pubmed.ncbi.nlm.nih.gov/17877614

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EPR determination of low molecular weight iron content applied to whole rat hepatocytes

Autor: O, Sergent, J P, Anger, G, Lescoat, N, Pasdeloup, P, Cillard, J, Cillard

Publikováno v: Cellular and molecular biology (Noisy-le-Grand, France). 43(5)

Electron paramagnetic resonance (EPR) has been described as suitable for the evaluation of low molecular weight (LMW) iron in liver homogenates after chelation by desferrioxamine. LMW iron is a highly toxic iron species incriminated in free radical p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3c21c5b3bb0e4aaa9a14b5b1cd8c4330
https://pubmed.ncbi.nlm.nih.gov/9298601

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Kinetic evaluation of free malondialdehyde and enzyme leakage as indices of iron damage in rat hepatocyte cultures. Involvement of free radicals

Autor: I, Morel, G, Lescoat, J, Cillard, N, Pasdeloup, P, Brissot, P, Cillard

Publikováno v: Biochemical pharmacology. 39(11)

The present study relates to the effect of ferric iron supplementation on lipid peroxidation of adult rat hepatocyte pure cultures. Lipid peroxidation was evaluated by free malondialdehyde (MDA) using size exclusion chromatography (HPLC) as a specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dd272fb28a6822ca3cb32e1bb50c68ca
https://pubmed.ncbi.nlm.nih.gov/2344365

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Comparative Effect of the Oral Iron Chelators ICL670A and CP20 on Cell Proliferation, Apoptosis and Polyamine Metabolism in Rat and Human Liver Cell Cultures

Autor: N. Pasdeloup, François Gaboriau, Hans Peter Nick, Gérard Lescoat, Pierre Brissot, Karine Chantrel-Groussard

Publikováno v: Blood. 106:4448-4448

Iron overload increases the mitotic index in rat hepatocyte cultures stimulated by EGF. Iron, implicated in tumoral cell proliferation, promotes the development of the hepatocellular carcinoma. Conversely, iron chelation decreases cell proliferation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3bae1a73871b08674e891c04d9186808
https://doi.org/10.1182/blood.v106.11.4448.4448

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Modulation of Albumin Secretion by Ornithine Alpha-Ketoglutarate in Adult Rat Hepatocyte Cultures and a Human Hepatoma Cell Line (HepG2)

Autor: O. Loreal, P. Brissot, B. Desvergne, N. Pasdeloup, Y. Deugnier, Michel Bourel, Gérard Lescoat

Publikováno v: Annals of Nutrition and Metabolism. 33:252-260

Cocultured adult rat hepatocytes and a human hepatoma cell line (HepG2) were maintained in an arginine-free medium with or without ornithine α-ketoglutarate. This drug increased greatly hep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00e46e67dcddf02f104395bec65866a2
https://doi.org/10.1159/000177542

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Modulation of albumin secretion by ornithine alpha-ketoglutarate in adult rat hepatocyte cultures and a human hepatoma cell line (HepG2)

Autor: G, Lescoat, B, Desvergne, O, Loreal, N, Pasdeloup, Y, Deugnier, M, Bourel, P, Brissot

Publikováno v: Annals of nutritionmetabolism. 33(5)

Cocultured adult rat hepatocytes and a human hepatoma cell line (HepG2) were maintained in an arginine-free medium with or without ornithine alpha-ketoglutarate. This drug increased greatly hepatocyte albumin secretion in both culture models. L-Ornit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bcdc532f11dfcf73ccbb521c8cda9160
https://pubmed.ncbi.nlm.nih.gov/2624435

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