Zobrazeno 1 - 10
of 14
pro vyhledávání: '"N. P. M. Smit"'
Autor:
N. P. M. Smit, A. Mieke Mommaas, J. Borovanský, Denise Eygendaal, Stan Pavel, A. J. Winder, Bert J. Vermeer
Publikováno v:
Archives of Dermatological Research. 289:145-150
Normal melanosome biogenesis requires the association of structural proteins with tyrosinase. 3T3 Swiss fibroblasts transfected with mouse tyrosinase cDNA (line 13.4, clone c) are a unique system in which melanogenesis takes place in the absence of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804185c68277eab56d3cbd3e291bd139
https://doi.org/10.1007/s004030050170
https://doi.org/10.1007/s004030050170
Publikováno v:
Biochemical Pharmacology. 48:743-752
Catechols may interfere in melanogenesis by causing increased levels of toxic quinones. Several catechols and known inhibitors of the enzyme catechol- O -methyltransferase (COMT) were therefore tested for their toxicity towards a pigmented melanoma c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29d5a9d8748cfbc5a10061c3893a8e0d
https://doi.org/10.1016/0006-2952(94)90052-3
https://doi.org/10.1016/0006-2952(94)90052-3
Autor:
N P M Smit, R E A Musson
Publikováno v:
Current Medicinal Chemistry, 18(2), 301-15
Current Medicinal Chemistry, 18(2), 301-315
Current Medicinal Chemistry, 18(2), 301-315
Calcineurin (protein phosphatase 3, Cn) is best known for its central position in Ca(2+)-dependent T-cell signaling. Interest in calcineurin has, however, conserved its momentum as new Ca(2+)-dependent pathways have been steadily surfacing in several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89edb176f9bfe5477b29c948f0e992ff
https://hdl.handle.net/1887/118534
https://hdl.handle.net/1887/118534
Autor:
M. Bogaerts, A. F. L. Later, Robert J.M. Klautz, L. M. G. van de Watering, Anneke Brand, L.S. Sitniakowsky, J. A. van Hilten, N. P. M. Smit
Publikováno v:
Transfusion Medicine, 21(4), 236-246
Transfusion Medicine, 21(4), 236-46
Transfusion Medicine, 21(4), 236-46
Aim: To determine the effect of red blood cell (RBC) transfusions during cardiac surgery on cytokine gene expression (GE) in relation to multiple organ failure (MOF) development after systemic inflammatory response syndrome (SIRS). Background: RBC tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3ed91141f4471f1a6e5bf8f22ac983
https://hdl.handle.net/1887/110439
https://hdl.handle.net/1887/110439
Autor:
Stan Pavel, N. P. M. Smit, Marlene van den Berg, Judith C. Heikoop, Carlo W.T. van Roermund, Ronald J.A. Wanders, Hans Aerts
Publikováno v:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1181(1), 1-6. Elsevier
In order to obtain information on the disputed nature of melanosomes a comparison was made between the localization of melanosomal markers with those of other well-defined subcellular organelles such as lysosomes and peroxisomes. The distribution of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c398a5346c04d2ad0d1757e8d5d8ae
https://doi.org/10.1016/0925-4439(93)90082-c
https://doi.org/10.1016/0925-4439(93)90082-c
Publikováno v:
Melanoma Research. 2:295-304
Substituted phenolic compounds were previously shown to exhibit cytotoxicity towards epithelial cells in the presence of the enzyme tyrosinase as a result of the formation of their quinone products. Seventeen of these compounds were tested for cytoto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9aaf17df47c06f1af48175d5e70c2b
https://doi.org/10.1097/00008390-199212000-00002
https://doi.org/10.1097/00008390-199212000-00002
Publikováno v:
Analytical biochemistry, 190(2), 286-291. Academic Press Inc.
A new sensitive method for the determination of catechol O-methyltransferase activity has been developed. The method is based on the O-methylation of the indolic intermediates of melanin metabolism. The substrate, 5,6-dihydroxyindole-2-carboxylic aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3cc53a7d0f20f2f7676a07a49d73596
https://doi.org/10.1016/0003-2697(90)90195-f
https://doi.org/10.1016/0003-2697(90)90195-f
SummaryPrevious studies have shown that low-dose ultraviolet-A (UVA-1) total body irradiations were capable of improving disease activity in patients with systemic lupus erythematosus (SLE). We hypothesized that UVA-1-induced suppression of immunoglo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5425fa7349640e603affd3f4e93c337c
https://europepmc.org/articles/PMC1809712/
https://europepmc.org/articles/PMC1809712/
Autor:
S, Pavel, N P M, Smit
Publikováno v:
Nederlands tijdschrift voor geneeskunde. 148(46)
Pigmented naevi (moles) are increasingly regarded as risk factors for the development of melanoma. The probability of melanoma developing from congenital naevi is proportional to the volume of the naevi. The risk of melanoma development from large na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f42b12491c52069b80b08e35c316536f
https://pubmed.ncbi.nlm.nih.gov/15584541
https://pubmed.ncbi.nlm.nih.gov/15584541
Publikováno v:
Cell death and differentiation, 12(6), 678-679. Nature Publishing Group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c20aa91dd1a2aa26d9333f2ff31644c
https://doi.org/10.1038/sj.cdd.4401630
https://doi.org/10.1038/sj.cdd.4401630