Zobrazeno 1 - 10
of 74
pro vyhledávání: '"N. Oprescu"'
Autor:
Rebecca Meyer-Schuman, Allison R. Cale, Jennifer A. Pierluissi, Kira E. Jonatzke, Young N. Park, Guy M. Lenk, Stephanie N. Oprescu, Marina A. Grachtchouk, Andrzej A. Dlugosz, Asim A. Beg, Miriam H. Meisler, Anthony Antonellis
Publikováno v:
HGG Advances, Vol 5, Iss 3, Pp 100324- (2024)
Summary: Aminoacyl-tRNA synthetases (ARSs) are ubiquitously expressed, essential enzymes that complete the first step of protein translation: ligation of amino acids to cognate tRNAs. Genes encoding ARSs have been implicated in myriad dominant and re
Externí odkaz:
https://doaj.org/article/74fe00848b15473285079ab25600691e
Autor:
Stephanie N. Oprescu, Nick Baumann, Xiyue Chen, Qiang Sun, Yu Zhao, Feng Yue, Huating Wang, Shihuan Kuang
Publikováno v:
Skeletal Muscle, Vol 13, Iss 1, Pp 1-21 (2023)
Abstract Transcription factors (TFs) play key roles in regulating differentiation and function of stem cells, including muscle satellite cells (MuSCs), a resident stem cell population responsible for postnatal regeneration of the skeletal muscle. Sox
Externí odkaz:
https://doaj.org/article/5567b739b612499f8e2ba3db25ad7864
Autor:
Kun Ho Kim, Stephanie N. Oprescu, Madigan M. Snyder, Aran Kim, Zhihao Jia, Feng Yue, Shihuan Kuang
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113329- (2023)
Summary: Development is regulated by various factors, including protein methylation status. While PRMT5 is well known for its roles in oncogenesis by mediating symmetric di-methylation of arginine, its role in normal development remains elusive. Usin
Externí odkaz:
https://doaj.org/article/4b7bad966b4743ca908d2b45cd3de941
Autor:
Zhihao Jia, Xiyue Chen, Jingjuan Chen, Lijia Zhang, Stephanie N. Oprescu, Nanjian Luo, Yan Xiong, Feng Yue, Shihuan Kuang
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 2, Pp n/a-n/a (2022)
Abstract Propionate is a gut microbial metabolite that has been reported to have controversial effects on metabolic health. Here we show that propionate is activated by acyl‐CoA synthetase short‐chain family member 3 (ACSS3), located on the mitoc
Externí odkaz:
https://doaj.org/article/a7dbdc793a814880958296fe8f80db4d
Autor:
Aleksandra Siekierska, Hannah Stamberger, Tine Deconinck, Stephanie N. Oprescu, Michèle Partoens, Yifan Zhang, Jo Sourbron, Elias Adriaenssens, Patrick Mullen, Patrick Wiencek, Katia Hardies, Jeong-Soo Lee, Hoi-Khoanh Giong, Felix Distelmaier, Orly Elpeleg, Katherine L. Helbig, Joseph Hersh, Sedat Isikay, Elizabeth Jordan, Ender Karaca, Angela Kecskes, James R. Lupski, Reka Kovacs-Nagy, Patrick May, Vinodh Narayanan, Manuela Pendziwiat, Keri Ramsey, Sampathkumar Rangasamy, Deepali N. Shinde, Ronen Spiegel, Vincent Timmerman, Sarah von Spiczak, Ingo Helbig, C4RCD Research Group, AR working group of the EuroEPINOMICS RES Consortium, Sarah Weckhuysen, Christopher Francklyn, Anthony Antonellis, Peter de Witte, Peter De Jonghe
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
tRNAs are linked with their cognate amino acid by aminoacyl tRNA synthetases (ARS). Here, the authors report a developmental encephalopathy associated with biallelic VARS variants (valyl-tRNA synthetase) that lead to loss of function, as determined b
Externí odkaz:
https://doaj.org/article/ea0d836e898d4bdc88b6a0d98d57ecd8
Publikováno v:
STAR Protocols, Vol 1, Iss 2, Pp 100051- (2020)
Summary: Single-cell RNA sequencing (scRNA-seq) is a powerful technique for deconvoluting and clustering thousands of otherwise intermingled cells based on their gene expression. Here, we present a complete protocol for the unbiased evaluation of reg
Externí odkaz:
https://doaj.org/article/5d200d608cca47609ad2693bcce8968a
Publikováno v:
iScience, Vol 23, Iss 4, Pp - (2020)
Summary: Mammalian skeletal muscle possesses a unique ability to regenerate, which is primarily mediated by a population of resident muscle stem cells (MuSCs) and requires a concerted response from other supporting cell populations. Previous targeted
Externí odkaz:
https://doaj.org/article/49cffcb8d0b7471faf1804f0b72cc33d
Autor:
Kun Ho Kim, Zhihao Jia, Madigan M. Snyder, Jingjuan Chen, Jiamin Qiu, Stephanie N. Oprescu, Xiyue Chen, Sabriya A Syed, Feng Yue, Bruno T. Roseguini, Anthony N. Imbalzano, Changdeng Hu, Shihuan Kuang
The skeletal muscle plays a key role in systemic energy homeostasis besides its canonical contractile function, but what couples these functions is poorly defined. Protein Arginine MethylTransferase 5 (PRMT5) is a well-known oncoprotein but also expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99fb57d7315842f583c353f9b5f002dc
https://doi.org/10.1101/2022.11.04.515165
https://doi.org/10.1101/2022.11.04.515165
Autor:
Zhihao Jia, Xiyue Chen, Jingjuan Chen, Lijia Zhang, Stephanie N. Oprescu, Nanjian Luo, Yan Xiong, Feng Yue, Shihuan Kuang
Publikováno v:
Clinical and translational medicine. 12(2)
Propionate is a gut microbial metabolite that has been reported to have controversial effects on metabolic health. Here we show that propionate is activated by acyl-CoA synthetase short-chain family member 3 (ACSS3), located on the mitochondrial inne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709e4b629cfb74f2cbcd33b9ceccc81f
https://pubmed.ncbi.nlm.nih.gov/35184387
https://pubmed.ncbi.nlm.nih.gov/35184387
Autor:
Kun Ho Kim, Ying Peng, Jiamin Qiu, Stephanie N. Oprescu, Pengpeng Bi, Renjie Shang, Lijia Zhang, Shawn S. Donkin, Madigan M. Snyder, Feng Yue, Jingjuan Chen, Shihuan Kuang
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 35(11)
Obesity and metabolic disorders caused by energy surplus pose an increasing concern within the global population. Brown adipose tissue (BAT) dissipates energy through mitochondrial non-shivering thermogenesis, thus representing a powerful agent again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb56c753869d6d9dc58066c5a3cca98
https://pubmed.ncbi.nlm.nih.gov/34669999
https://pubmed.ncbi.nlm.nih.gov/34669999