Zobrazeno 1 - 10
of 105
pro vyhledávání: '"N. Nguyen Ba"'
Publikováno v:
Tribology in Industry, Vol 42, Iss 4, Pp 597-607 (2020)
This paper presents research on a prediction method of surface roughness in the hole turning process of 3X13 steel. The experimental matrix was designed by using the Central Composite Design (CCD) with four input parameters including cutting speed, f
Externí odkaz:
https://doaj.org/article/6633e03a5f2049a5a4b15708a9138ac2
Autor:
Melina Claussnitzer, Victoria N. Parikh, Alex H. Wagner, Jeremy A. Arbesfeld, Carol J. Bult, Helen V. Firth, Lara A. Muffley, Alex N. Nguyen Ba, Kevin Riehle, Frederick P. Roth, Daniel Tabet, Benedetta Bolognesi, Andrew M. Glazer, Alan F. Rubin
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-8 (2024)
Abstract Multiplexed assays of variant effect (MAVEs) have emerged as a powerful approach for interrogating thousands of genetic variants in a single experiment. The flexibility and widespread adoption of these techniques across diverse disciplines h
Externí odkaz:
https://doaj.org/article/ee5b2abbc9bf4533aed98196fa9861b1
Autor:
Alex N Nguyen Ba, Katherine R Lawrence, Artur Rego-Costa, Shreyas Gopalakrishnan, Daniel Temko, Franziska Michor, Michael M Desai
Publikováno v:
eLife, Vol 11 (2022)
Mapping the genetic basis of complex traits is critical to uncovering the biological mechanisms that underlie disease and other phenotypes. Genome-wide association studies (GWAS) in humans and quantitative trait locus (QTL) mapping in model organisms
Externí odkaz:
https://doaj.org/article/fc76b9c91a6b4f2d98062105470fe809
Publikováno v:
eLife, Vol 10 (2021)
Evolutionary adaptation to a constant environment is driven by the accumulation of mutations which can have a range of unrealized pleiotropic effects in other environments. These pleiotropic consequences of adaptation can influence the emergence of s
Externí odkaz:
https://doaj.org/article/11f5bf11feae423aa676a36ecff8e924
Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations
Autor:
Milo S Johnson, Shreyas Gopalakrishnan, Juhee Goyal, Megan E Dillingham, Christopher W Bakerlee, Parris T Humphrey, Tanush Jagdish, Elizabeth R Jerison, Katya Kosheleva, Katherine R Lawrence, Jiseon Min, Alief Moulana, Angela M Phillips, Julia C Piper, Ramya Purkanti, Artur Rego-Costa, Michael J McDonald, Alex N Nguyen Ba, Michael M Desai
Publikováno v:
eLife, Vol 10 (2021)
Laboratory experimental evolution provides a window into the details of the evolutionary process. To investigate the consequences of long-term adaptation, we evolved 205 Saccharomyces cerevisiae populations (124 haploid and 81 diploid) for ~10,000 ge
Externí odkaz:
https://doaj.org/article/e8d8f2f76fba43eeaf3f7eae82f045e8
Publikováno v:
MicrobiologyOpen, Vol 9, Iss 2, Pp n/a-n/a (2020)
Abstract Ecologists have long studied the evolution of niche breadth, including how variability in environments can drive the evolution of specialism and generalism. This concept is of particular interest in viruses, where niche breadth evolution may
Externí odkaz:
https://doaj.org/article/5a7019ce204e45a6af8b303222c7bcd2
Publikováno v:
eLife, Vol 8 (2019)
Intrinsically disordered regions make up a large part of the proteome, but the sequence-to-function relationship in these regions is poorly understood, in part because the primary amino acid sequences of these regions are poorly conserved in alignmen
Externí odkaz:
https://doaj.org/article/1ef704afc0bf411db20f5fbcef6b58fb
Publikováno v:
PLoS Genetics, Vol 15, Iss 2, p e1007958 (2019)
Screens for epistatic interactions have long been used to characterize functional relationships corresponding to protein complexes, metabolic pathways, and other functional modules. Although epistasis between adaptive mutations is also common in labo
Externí odkaz:
https://doaj.org/article/2e23ec2771b34af293ea7a857a39a31b
Publikováno v:
PLoS Genetics, Vol 13, Iss 4, p e1006735 (2017)
Regulatory networks often increase in complexity during evolution through gene duplication and divergence of component proteins. Two models that explain this increase in complexity are: 1) adaptive changes after gene duplication, such as resolution o
Externí odkaz:
https://doaj.org/article/f0ef18ca1ff94da990049a0607b78b52
Autor:
Claire A, Chochinov, Alex N, Nguyen Ba
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2477
The use of DNA barcodes for determining changes in genotype frequencies has been instrumental to increase the scale at which we can phenotype strain libraries by using next-generation sequencing technologies. Here, we describe the determination of st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7df5e078ee19b6fa62f180b80dddf2a3
https://pubmed.ncbi.nlm.nih.gov/35524129
https://pubmed.ncbi.nlm.nih.gov/35524129