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Sphingosine-1-phosphate, a metabolite of sphingosine, increases phosphatidic acid levels by phospholipase D activation

Autor: Sarah Spiegel, Hong Zhang, Mark E. Mattie, N. N. Desai, Ana Olivera

Publikováno v: Journal of Biological Chemistry. 267:23122-23128

Sphingosine and sphingosine-1-phosphate, metabolites of membrane sphingolipids, have recently been shown to stimulate release of calcium from internal sources and to increase proliferation of quiescent Swiss 3T3 fibroblasts (Zhang, H., Desai, N. N.,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30fbde369183406b9b279551377384b4
https://doi.org/10.1016/s0021-9258(18)50065-x

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Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines

Autor: N. N. Desai, Sarah Spiegel

Publikováno v: Biochemical and Biophysical Research Communications. 181:361-366

The effect of spingosylphosphorylcholine on cellular proliferation was investigated in a variety of cell types. Spingosylphosphorylcholine at low concentrations greatly stimulated DNA synthesis and cell division in quiescent Swiss 3T3 fibroblasts. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fadbe1a34b6dd402b329b7bfe9bb39f
https://doi.org/10.1016/s0006-291x(05)81427-5

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Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation

Autor: Hong Zhang, Ana Olivera, N. N. Desai, Gary Brooker, Sarah Spiegel, Takashi Seki

Publikováno v: The Journal of Cell Biology

Sphingosine, a metabolite of membrane sphingolipids, regulates proliferation of quiescent Swiss 3T3 fibroblasts (Zhang, H., N. E. Buckley, K. Gibson. and S. Spiegel. 1990. J. Biol. Chem. 265:76-81). The present study provides new insights into the fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33efdfa7f151346e4de54bf39f3307b4
https://doi.org/10.1083/jcb.114.1.155

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Novel human endometrial cell line promotes blastocyst development

Autor: N N, Desai, E A, Kennard, D A, Kniss, C I, Friedman

Publikováno v: Fertility and sterility. 61(4)

To test and contrast the embryotrophic potential of an established human endometrial cell line to that of two other epithelial cell types: human oviduct and African monkey kidney (Vero) cells.Mouse IVF was performed. Subsequent development of embryos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8ae306fbcab439cbb6a69ce376f74595
https://pubmed.ncbi.nlm.nih.gov/7512055

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Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts

Autor: Takashi Seki, Sarah Spiegel, Gary Brooker, Ana Olivera, N. N. Desai, Mark E. Mattie, R. O. Carlson, Nancy E. Buckley

Publikováno v: The Journal of Cell Biology

Sphingosylphosphorylcholine (SPC), or lysophingomyelin, a wide-spectrum growth promoting agent for a variety of cell types (Desai, N. N., and S. Spiegel. 1991. Biochem. Biophys. Res. Comm. 181: 361-366), stimulates cellular proliferation of quiescent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::992f8d1e8ebd2edf6551ce65a7bab8a8
https://pubmed.ncbi.nlm.nih.gov/8389770

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Increases in phosphatidic acid levels accompany sphingosine-stimulated proliferation of quiescent Swiss 3T3 cells

Autor: H, Zhang, N N, Desai, J M, Murphey, S, Spiegel

Publikováno v: The Journal of biological chemistry. 265(34)

Sphingosine, a breakdown product of cellular sphingolipids, has recently been shown to stimulate DNA synthesis and act synergistically with known growth factors to induce proliferation of quiescent Swiss 3T3 fibroblasts (Hong, Z., Buckley, N. E., Gib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fc321556e2b2a8f4dbf35ac6c90199a1
https://pubmed.ncbi.nlm.nih.gov/2250025

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