Výsledky vyhledávání - "N. Muge Kuyumcu-Martinez"

Increased Steady-State Levels of CUGBP1 in Myotonic Dystrophy 1 Are Due to PKC-Mediated Hyperphosphorylation

Autor: Guey-Shin Wang, N. Muge Kuyumcu-Martinez, Thomas A. Cooper

Publikováno v: Molecular Cell. 28(1):68-78

The genetic basis of myotonic dystrophy type 1 (DM1) is a CTG expansion in the 3' untranslated region (UTR) of DMPK. The pathogenic mechanism involves an RNA gain of function in which the repeat-containing transcripts accumulate in nuclei and alter t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a582971f7c49d4db20a3e41dac945a9f

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Cleavage of Poly(A)-Binding Protein by Poliovirus 3C Protease Inhibits Host Cell Translation: a Novel Mechanism for Host Translation Shutoff

Autor: Marc E. Van Eden, Richard E. Lloyd, Patrick Younan, N. Muge Kuyumcu-Martinez

Publikováno v: Molecular and Cellular Biology. 24:1779-1790

Cleavage of eukaryotic translation initiation factor 4GI (eIF4GI) by viral 2A protease (2Apro) has been proposed to cause severe translation inhibition in poliovirus-infected cells. However, infections containing 1 mM guanidine-HCl result in eIF4GI c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ccd77d28a81bef92e34456b2bb7b6d
https://doi.org/10.1128/mcb.24.4.1779-1790.2004

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Efficient Cleavage of Ribosome-Associated Poly(A)-Binding Protein by Enterovirus 3C Protease

Autor: Michelle Joachims, N. Muge Kuyumcu-Martinez, Richard E. Lloyd

Publikováno v: Journal of Virology. 76:2062-2074

Poliovirus (PV) causes a rapid and drastic inhibition of host cell cap-dependent protein synthesis during infection while preferentially allowing cap-independent translation of its own genomic RNA via an internal ribosome entry site element. Inhibiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4529ca9b5b08682216e6bf01ea4c2592
https://doi.org/10.1128/jvi.76.5.2062-2074.2002

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Proteolytic Cleavage of the Catalytic Subunit of DNA-Dependent Protein Kinase during Poliovirus Infection

Autor: Peter Sarnow, Kareem L. Graham, Carlos Rivera, Sunny S. Choe, N. Muge Kuyumcu-Martinez, Paul J. Utz, Kurt E. Gustin, Richard E. Lloyd

DNA-dependent protein kinase (DNA-PK) is a serine/threonine kinase that has critical roles in DNA double-strand break repair, as well as B- and T-cell antigen receptor rearrangement. The DNA-PK enzyme consists of the Ku regulatory subunit and a 450-k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8b7b2262db27f07b2e8fbcf37e924c
https://europepmc.org/articles/PMC416498/

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