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Akademický článek

HSPs drive dichotomous T-cell immune responses via DNA methylome remodelling in antigen presenting cells

Autor: Lauren B. Kinner-Bibeau, Abigail L. Sedlacek, Michelle N. Messmer, Simon C. Watkins, Robert J. Binder

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)

Low dose of the heat shock protein gp96 can drive effector T-cell responses, yet high-dose gp96 is immunosuppressive by expanding the regulatory T-cell population. Here the authors explain this dichotomy by showing that high-dose gp96 can drive plasm

Externí odkaz: https://doaj.org/article/cf78ebbf481d47ad9ecf5de60d0357a8

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Akademický článek

RIPK3 Activation Leads to Cytokine Synthesis that Continues after Loss of Cell Membrane Integrity

Autor: Susana L. Orozco, Brian P. Daniels, Nader Yatim, Michelle N. Messmer, Giovanni Quarato, Haiyin Chen-Harris, Sean P. Cullen, Annelise G. Snyder, Pooja Ralli-Jain, Sharon Frase, Stephen W.G. Tait, Douglas R. Green, Matthew L. Albert, Andrew Oberst

Publikováno v: Cell Reports, Vol 28, Iss 9, Pp 2275-2287.e5 (2019)

Summary: Necroptosis is a form of programmed cell death that is defined by activation of the kinase RIPK3 and subsequent cell membrane permeabilization by the effector MLKL. RIPK3 activation can also promote immune responses via production of cytokin

Externí odkaz: https://doaj.org/article/7ffc260e505644a99f8c4f409cad4f57

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Akademický článek

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Data from β-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8+ T Cells and Undermines Checkpoint Inhibitor Therapy

Autor: Elizabeth A. Repasky, Bonnie L. Hylander, Scott I. Abrams, Kristopher Attwood, Michelle N. Messmer, Jason W.-L. Eng, Kathleen M. Kokolus, Haichao Liu, Brian Niedzwecki, Lauren Evans, Thejaswini Giridharan, Cameron R. MacDonald, Guanxi Qiao, Mark J. Bucsek

The immune context of tumors has significant prognostic value and is predictive of responsiveness to several forms of therapy, including immunotherapy. We report here that CD8+ T-cell frequency and functional orientation within the tumor microenviron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aec282661638d66a258465c3d3cac9c3
https://doi.org/10.1158/0008-5472.c.6509076.v1

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Figure S6 from β-Adrenergic Signaling in Mice Housed at Standard Temperatures Suppresses an Effector Phenotype in CD8+ T Cells and Undermines Checkpoint Inhibitor Therapy

This data shows that housing mice at 30 degrees Celsius improves the efficacy of anti-PD-1 in both 4T1 and B16-OVA tumor-bearing mice indicating that cool housing temperatures (22 degrees C) impairs the efficacy of anti-PD-1 in murine tumor models.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600baffff9aca5eeba91cd8561516aec
https://doi.org/10.1158/0008-5472.22414770

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Akademický článek

Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes

Autor: Amy W Ku, Jason B Muhitch, Colin A Powers, Michael Diehl, Minhyung Kim, Daniel T Fisher, Anand P Sharda, Virginia K Clements, Kieran O'Loughlin, Hans Minderman, Michelle N Messmer, Jing Ma, Joseph J Skitzki, Douglas A Steeber, Bruce Walcheck, Suzanne Ostrand-Rosenberg, Scott I Abrams, Sharon S Evans

Publikováno v: eLife, Vol 5 (2016)

Myeloid-derived suppressor cells (MDSC) contribute to an immunosuppressive network that drives cancer escape by disabling T cell adaptive immunity. The prevailing view is that MDSC-mediated immunosuppression is restricted to tissues where MDSC co-min

Externí odkaz: https://doaj.org/article/3703c01018fe4546bf5280e8e6082a72

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Akademický článek

CD91-Dependent Modulation of Immune Responses by Heat Shock Proteins: A Role in Autoimmunity

Autor: Robert J. Binder, Yu Jerry Zhou, Michelle N. Messmer, Sudesh Pawaria

Publikováno v: Autoimmune Diseases, Vol 2012 (2012)

Heat shock proteins (HSPs) have been known for decades for their ability to protect cells under stressful conditions. In the 1980s a new role was ascribed for several HSPs given their ability to elicit specific immune responses in the setting of canc

Externí odkaz: https://doaj.org/article/f170cfafc3fd44ce8ad8c0e0fc51676b

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Akademický článek

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