Impact of transient down-regulation of DREAM in human embryonic stem cell pluripotency

Autor: A. Fontán-Lozano, V. Capilla-Gonzalez, Y. Aguilera, N. Mellado, A.M. Carrión, B. Soria, A. Hmadcha

Publikováno v: Stem Cell Research, Vol 16, Iss 3, Pp 568-578 (2016)

Little is known about the functions of downstream regulatory element antagonist modulator (DREAM) in embryonic stem cells (ESCs). However, DREAM interacts with cAMP response element-binding protein (CREB) in a Ca2+-dependent manner, preventing CREB b

Externí odkaz: https://doaj.org/article/0897594fb97a46668154761b21999339

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Derivation of HVR1, HVR2 and HVR3 human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis (PGD) for monogenic disorder

Autor: Maria Dolores Lozano-Arana, N. Mellado, Javier Sánchez, Yolanda Aguilera, Guillermo Antiñolo, Abdelkrim Hmadcha, José Palacios, Cristina Moya, Bernat Soria, Luis Sánchez-Palazón

Publikováno v: Stem Cell Research, Vol 16, Iss 3, Pp 635-639 (2016)
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Digital.CSIC. Repositorio Institucional del CSIC

From 106 human blastocyts donate for research after in vitro fertilization (IVF) and preimplantation genetic diagnosis (PGD) for monogenetic disorder, 3 human embryonic stem cells (hESCs) HVR1, HVR2 and HVR3 were successfully derived. HVR1 was assume

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1612d3a8a25eae1fe35202ed3e04c954

miR-7 Modulates hESC Differentiation into Insulin-Producing Beta-like Cells and Contributes to Cell Maturation

Autor: Tarik Smani, Christian Claude Lachaud, Javier López-Beas, Vivian Capilla-Gonzalez, Franz Martín, Yolanda Aguilera, Bernat Soria, N. Mellado, Abdelkrim Hmadcha

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 12, Iss, Pp 463-477 (2018)
Molecular Therapy. Nucleic Acids
Digital.CSIC. Repositorio Institucional del CSIC
instname
idUS. Depósito de Investigación de la Universidad de Sevilla

Human pluripotent stem cells retain the extraordinary capacity to differentiate into pancreatic beta cells. For this particular lineage, more effort is still required to stress the importance of developing an efficient, reproducible, easy, and cost-e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a130e4caa90a3c7b4f0107e9b871f72
https://pubmed.ncbi.nlm.nih.gov/30195784