Zobrazeno 1 - 10
of 28
pro vyhledávání: '"N. Maruthi Kumar"'
Autor:
Surela Bhattacharya, N Maruthi Kumar, Arnab Ganguli, Mukund P Tantak, Dalip Kumar, Gopal Chakrabarti
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76286 (2013)
Thiadiazoles are one of the most widely utilized agents in medicinal chemistry, having a wide range of pharmacologic activity. Microtubules (MTs) have always remained a sought-after target in rapidly proliferating cancer cells. We screened for the gr
Externí odkaz:
https://doaj.org/article/c3704de1b19e453986319d2ed2f851f9
Autor:
Arnab Ganguli, Amlan Das, Dalip Kumar, Mukund P. Tantak, N. Maruthi Kumar, Satabdi Datta, Dipanwita Das Mukherjee, Gopal Chakrabarti
Publikováno v:
Biochemistry. 55(21)
The biological significance of microtubules makes them a validated target of cancer therapy. In this study, we have utilized indole, an important pharmacological scaffold, to synthesize novel bis(indolyl)-hydrazide-hydrazone derivatives (NMK-BH compo
Publikováno v:
ChemMedChem. 7:1915-1920
A recipe for potency: A novel series of bis(indolyl)-1,3,4-oxadiazoles was prepared from the corresponding hydrazide-hydrazones via iodobenzene diacetate-promoted oxidative cyclization. Evaluation against a panel of human cancer cell lines revealed t
Publikováno v:
European Journal of Medicinal Chemistry. 55:432-438
A series of 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles 6a – v were prepared and studied for their anticancer activity against selected human cancer cell lines. The reaction of indolylhydrazides 3a – h with a variety of aryl isothiocyanates 4 affo
Publikováno v:
Tetrahedron Letters. 52:1983-1986
A simple, efficient and high yielding greener protocol for the synthesis of substituted thiazoles and imidazoles is described that utilizes the reaction of readily available α-tosyloxy ketones with variety of thioamides/amidines in water.
Autor:
Tarasankar Das, Prasun Ghosh, Arnab Maity, Syed S. Jaffer, Dalip Kumar, Pradipta Purkayastha, N. Maruthi Kumar
Publikováno v:
Journal of Luminescence. 131:147-154
Photophysical modulations of three indoloquinoline derivatives, viz., 5-Methyl-5H-indolo[3,2-c]quinoline (MIQ), 8-Chloro-5-methyl-5H-indolo[3,2-c]quinoline (CMIQ), and 2,8-Dichloro-5-methyl-5H-indolo[3,2-c]quinoline (DCMIQ) have been studied. These c
Publikováno v:
European Journal of Medicinal Chemistry. 45:4664-4668
A series of 5-(3-indolyl)-2-substituted-1,3,4-thiadiazoles 5a-m were synthesized and their cytotoxicity analyzed against six human cancer cell lines. The reaction of indole-3-carboxylic acid 3 with aryl or heteroaryl hydrazides afforded the N,N'-diac
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3916-3919
A series of indolyl chalcones were synthesized and evaluated in vitro for their anticancer activity against three human cancer cell lines. Compounds 3b-d, 3h, 3j, 3l, 3m, 4g, and 4j showed significant cytotoxicity, particularly, indolyl chalcones 3l
Publikováno v:
European Journal of Medicinal Chemistry. 45:1244-1249
A series of 4-(3′-indolyl)oxazole congeners have been synthesized and studied for their cytotoxicity against six cancer cell lines. Reaction of 3-acetyl-1′-benzenesulfonylindole with [hydroxy(tosyloxy)iodo]benzene afforded pure 3-tosyloxyacetyl-1
Facile and metal-free syntheses of natural and natural product-inspired bioactive heterocycles are of paramount importance in drug discovery program; therefore, it is highly desirable to develop efficient protocols to generate a diverse library of dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad194723f23cc66e883bf92aa3faf5a7
https://doi.org/10.1016/b978-0-12-800070-0.00014-1
https://doi.org/10.1016/b978-0-12-800070-0.00014-1