Výsledky vyhledávání - "N. M. Perova"

SN H reactions of 3-fluoronitroarenes with chloromethyl sulfone as the method for the construction of 6-fluoro-3-sulfonylindoles

Autor: V. N. Charushin, G. A. Zhumabaeva, S. K. Kotovskaya, O. N. Chupakhin, N. M. Perova

Publikováno v: Russian Chemical Bulletin. 56:2048-2053

5-R-6-Fluoro-3-phenylsulfonylindoles were synthesized by the SN H reaction of 3-fluoronitrobenzenes with chloromethyl phenyl sulfone in DMSO in the presence of KOH with subsequent reduction of the nitro group and intramolecular cyclization of imidate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34bfca756eeaae40a9d1241c9e2004d1
https://doi.org/10.1007/s11172-007-0320-9

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Synthesis and antiviral activity of fluorinated 3-phenyl-1,2,4-benzotriazines

Autor: N. M. Perova, Z. M. Baskakova, N. I. Bormotov, E. F. Belanov, V. N. Charushin, G. A. Zhumabaeva, O. A. Serova, S. K. Kotovskaya, Sergey Balakhnin, O. N. Chupakhin

Publikováno v: Pharmaceutical Chemistry Journal. 41:62-68

New synthetic approaches to fluorinated 3-phenyl-1,2,4-benzotriazines for biological testing have been elaborated. 1-(3,4-Difluorophenyl)-3,5-diphenylformazan (IVa) was synthesized via dinitriding of 3,4-difluoroaniline, followed by azo-addition of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3cd591fbe00675aa6a0ae293914663d
https://doi.org/10.1007/s11094-007-0014-5

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Tandem of nucleophilic substitution of hydrogen and cyclocondensation with participation of nitro group in the synthesis of fluorine-containing 3-amino-1,2,4-benzotriazines

Autor: S. K. Kotovskaya, G. A. Zhumabaeva, N. M. Perova, O. N. Chupakhin, V. N. Charushin

Publikováno v: Russian Chemical Bulletin. 55:1243-1247

Reactions of 3-fluoro-1-nitrobenzenes with guanidine hydrochloride in THF in the presence of ButOK gave isomeric 5-and 7-fluoro-containing 3-amino-1,2,4-benzotriazines.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72739575395b9cd191b791890621be32
https://doi.org/10.1007/s11172-006-0406-9

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[Untitled]

Autor: S. A. Romanova, N. M. Perova, Oleg N. Chupakhin, V. N. Charushin, Z. M. Baskakova, S. K. Kotovskaya

Publikováno v: Russian Journal of Organic Chemistry. 37:564-569

2-Mercapto-5,6-difluorobenzimidazole reacts with aliphatic and alicyclic ketones in acetic acid in the presence of catalytic amount of sulfuric acid to afford fluorinated derivatives of 2,3-disubstituted benz[4,5]imidazo[2,1-b][1,3]thiazoles. Reactio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::074edda500eeea1cb8adb0e687af10e7
https://doi.org/10.1023/a:1012446305955

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Synthesis of new fluorine-containing derivatives of quinoxaline 1,4-dioxides and condensed systems derived from them

Autor: Svetlana K. Kotovskaya, Z. M. Baskakova, V. N. Charushin, N. M. Perova, Oleg N. Chupakhin

Publikováno v: Chemistry of Heterocyclic Compounds. 35:459-469

The Beirut reaction of 5,6-difluorobenzofuroxan with 1,3-diketones, β-ketoesters, and amides produces 6,7-difluoroquinoxaline 1,4-dioxides. The condensation of 2-ethoxycarbonyl-6,7-difluoro-3-methylquinoxaline 1,4-dioxide is studied. Fluorinated fur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1169a0f4c10988d61975918ffb1e82cf
https://doi.org/10.1007/bf02319335

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[The antiaggregant action of 2-morpholino-5-(thienyl-2)-6-H-1,3,4-thiadiazine in in vitro and ex vivo experiments]

Autor: Iu S, Logvinova, V A, Makarov, O N, Chupakhin, L P, Sidorova, N M, Perova, V L, Rusinov

Publikováno v: Eksperimental'naia i klinicheskaia farmakologiia. 76(2)

The influence of 2-morpholino-5-(thienyl-2)-6-H-1,3,4-thiadiazine (H-29) on the platelet aggregation has been studied in experiments on donor plasma in vitro. It is established that H-29 causes a decrease in the platelet interaction induced by ADP an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::385a9188271e1ed26fbc3ebc1aaf3645
https://pubmed.ncbi.nlm.nih.gov/23631277

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Synthesis and antiaggregant activity of 2-cycloalkylamino-5-thienyl- and -5-furyl-6H-1,3,4-thiadiazines

Autor: Vasil'eva Tm, Vladimir L. Rusinov, Vadim Makarov, L. P. Sidorova, Oleg N. Chupakhin, N. M. Perova

Publikováno v: Pharmaceutical Chemistry Journal. 45

A series of new 5-(thienyl-2)-, 5-(furyl-2)-, and 5-(thienyl-3)-1,3,4-thiadiazine derivatives have been synthesized using methods based on the cyclocondensation of α-bromoacetylthiophenes or α-bromo-2-acetylfurans with 4-substituted thiosemicarbazi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f50df4b0ec4c5fccd502b75658b7c5c9
https://doi.org/10.1007/s11094-011-0614-y

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[Influence of new 1,3,4-thiadiazines on platelet aggregation in vitro and ex vivo]

Autor: O S, Logvinova, T M, Vasil'eva, V A, Makarov, O N, Chupakhin, L P, Sidorova, N M, Perova, V L, Rusinov

Publikováno v: Eksperimental'naia i klinicheskaia farmakologiia. 73(8)

The influence of new original 1,3,4-thiadiazines on the human platelet aggregation in vitro was studied. All substances inhibited the platelet aggregation induced by both ADP and arachidonic acid. 1,3,4-Thiadiazines L-19, H-30 and L-37 were the most

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5687569ca30803ee9755b922a19d5b8a
https://pubmed.ncbi.nlm.nih.gov/20919553

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