Výsledky vyhledávání - "N. M. Mazure"

Akademický článek

HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma

Autor: J. Contenti, Y. Guo, M. Larcher, L. Mirabal-Ortega, M. Rouleau, M. Irondelle, V. Tiroille, A. Mazzu, V. Duranton-Tanneur, F. Pedeutour, I. Ben-Sahra, C. Lago, G. Leva, L. Tiberi, G. Robert, C. Pouponnot, F. Bost, N. M. Mazure

Publikováno v: Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)

Abstract Medulloblastoma (MB) is the most prevalent brain cancer in children. Four subgroups of MB have been identified; of these, Group 3 is the most metastatic. Its genetics and biology remain less clear than the other groups, and it has a poor pro

Externí odkaz: https://doaj.org/article/6b0946adfba14408a97ab70bf63ae8b8

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Akademický článek

The mitochondrial NADH shuttle system is a targetable vulnerability for Group 3 medulloblastoma in a hypoxic microenvironment

Autor: J. Contenti, Y. Guo, A. Mazzu, M. Irondelle, M. Rouleau, C. Lago, G. Leva, L. Tiberi, I. Ben-Sahra, F. Bost, N. M. Mazure

Publikováno v: Cell Death and Disease, Vol 14, Iss 11, Pp 1-12 (2023)

Abstract Medulloblastoma is a cancerous brain tumor that affects mostly children. Among the four groups defined by molecular characteristics, Group 3, the least well characterized, is also the least favorable, with a survival rate of 50%. Current tre

Externí odkaz: https://doaj.org/article/76d76cbb72a14cd0a2c8832424260775

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Hypoxic VDAC1: a potential mitochondrial marker for cancer therapy

Autor: M Christiane, Brahimi-Horn, N M, Mazure

Publikováno v: Advances in experimental medicine and biology. 772

Finding new therapeutic targets to fight cancer is an ongoing quest. Because of insufficiencies in tumor vasculature, cells often are exposed to a hostile microenvironment that is low in oxygen (hypoxic) and nutrients. Thus, tumor cells face the chal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1c84e8c219aa9408bade52b802ea74e4
https://pubmed.ncbi.nlm.nih.gov/24272356

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Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/Akt pathway that results in glycogen synthase kinase-3 inactivation

Autor: E Y, Chen, N M, Mazure, J A, Cooper, A J, Giaccia

Publikováno v: Cancer research. 61(6)

Hypoxia initiates numerous intracellular signaling pathways important in regulating cell proliferation, differentiation, and death. In this study, we investigated the pathway that hypoxia uses to activate Akt and inactivate glycogen synthase kinase-3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e21d6c2807d55189b87fe814ee5b3083
https://pubmed.ncbi.nlm.nih.gov/11289110

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Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element

Autor: N M, Mazure, E Y, Chen, K R, Laderoute, A J, Giaccia

Publikováno v: Blood. 90(9)

Tumor angiogenesis, the development of new blood vessels, is a highly regulated process that is controlled genetically by alterations in oncogene and tumor suppressor gene expression and physiologically by the tumor microenvironment. Previous studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9e2f9102ecdf4badf8461356e71069e5
https://pubmed.ncbi.nlm.nih.gov/9345014

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Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression

Autor: N M, Mazure, E Y, Chen, P, Yeh, K R, Laderoute, A J, Giaccia

Publikováno v: Cancer research. 56(15)

Hypoxia can select for cells that have lost their apoptotic potential, thereby making them resistant to adverse conditions. However, long-term survival of transformed cells which have diminished apoptotic sensitivity when exposed to low oxygen condit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1395fee73d4e0a8c9cf347b7166de471
https://pubmed.ncbi.nlm.nih.gov/8758908

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